PI3Kα-IN-1
PI3Kα-IN-1 is a PI3Kα inhibitor (IC50 < 0.5 nM), and also inhibits mTOR (IC50: 104 nM).
For research use only. We do not sell to patients.
- CAS No.: 2100855-80-7
- Formula: C26H25N7O3
- Molecular Weight:483.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]<sup>|
PI3Kα <0.5 nM (IC50) |
In Vitro
PI3Kα-IN-1 shows good stability in the mouse liver microsome assay (t1/2 values > 60 minutes)[1].
PI3Kα-IN-1 (48 h) induces cytotoxicity in MDC7 cells with an IC50 value of around 170 nM[1].
PI3Kα-IN-1 (15-250 nM) inhibits phospho4EBP, phosphor-P70SK6 and phospho-473AKT in MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2100855-80-7
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Molecular Weight 483.52
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Formula C26H25N7O3
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SMILES
CC(NC1=CC=C(NC(NC2=CC=C(C3=NC(N4CCOCC4)=C5C(C=CC=N5)=N3)C=C2)=O)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kα-IN-1 Related Classifications
HY-124647 Related Classifications
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