Cat. No.: HY-122593

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PI3Kδ-IN-5

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PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC₅₀ of 0.9 nM.

For research use only. We do not sell to patients.

Purity: 99.62%
CAS No.: 2088525-31-7
Formula: C₂₃H₂₀FN₇O
Molecular Weight:429.45

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PI3Kδ-IN-5 Chemical Structure

CAS No.: 2088525-31-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC₅₀ of 0.9 nM^[1].

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
JeKo-1	IC₅₀	120 nM Compound: 120	Cytotoxicity against human JeKo1 cells Cytotoxicity against human JeKo1 cells	[PMID: 30582813]

Chemical Information

CAS No. 2088525-31-7
Appearance Solid
Molecular Weight 429.45
Formula C₂₃H₂₀FN₇O
Color Off-white to gray
SMILES

O=C(N)C1=CC=C(C2=NC(C3=NN(C)C(C4(C5=CC=CC=C5)CC4)=N3)=CN=C2N)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL (97.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3286 mL

11.6428 mL

23.2856 mL

5 mM

0.4657 mL

2.3286 mL

4.6571 mL

10 mM

0.2329 mL

1.1643 mL

2.3286 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Terstiege I, et al. Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors. Bioorg Med Chem Lett. 2017;27(3):679-687. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3286 mL	11.6428 mL	23.2856 mL	58.2140 mL
	5 mM	0.4657 mL	2.3286 mL	4.6571 mL	11.6428 mL
	10 mM	0.2329 mL	1.1643 mL	2.3286 mL	5.8214 mL
	15 mM	0.1552 mL	0.7762 mL	1.5524 mL	3.8809 mL
	20 mM	0.1164 mL	0.5821 mL	1.1643 mL	2.9107 mL
	25 mM	0.0931 mL	0.4657 mL	0.9314 mL	2.3286 mL
	30 mM	0.0776 mL	0.3881 mL	0.7762 mL	1.9405 mL
	40 mM	0.0582 mL	0.2911 mL	0.5821 mL	1.4553 mL
	50 mM	0.0466 mL	0.2329 mL	0.4657 mL	1.1643 mL
	60 mM	0.0388 mL	0.1940 mL	0.3881 mL	0.9702 mL
	80 mM	0.0291 mL	0.1455 mL	0.2911 mL	0.7277 mL

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PI3Kδ-IN-5

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Posttranslational Modification Library

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All PI3K Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PI3Kδ-IN-5 Related Classifications

HY-122593 Related Classifications