2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation
  3. PPAR Glucocorticoid Receptor
  4. PPARγ/GR modulator 1

PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes.

For research use only. We do not sell to patients.

PPARγ/GR modulator 1 Chemical Structure

PPARγ/GR modulator 1 Chemical Structure

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PPARγ/GR modulator 1 Related Antibodies

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Description

PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1].

IC50 & Target[1]

PPARγ

3.3 μM (Ki)

glucocorticoid receptor

33.6 μM (Ki)

In Vitro

PPARγ/GR modulator 1 (compound 11) stimulates production of adiponectin and leptin in hBM-MSCs, with IC50s of 2.87 and 2.82 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPARγ/GR modulator 1 Related Antibodies
In Vivo

PPARγ/GR modulator 1 (compound 11) (25-50 mg/kg; p.o. for 5 d) reduces serum glucose levels, serum lactate levels, and serum adiponectin levels in STZ-induced mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old male C57BL/6J mice were injected with180 mg/kg of STZ[1]
Dosage: 25, 50 mg/kg
Administration: Orally administration for 5 days
Result: Significant reduced serum glucose levels, serum lactate levels, and serum adiponectin levels.
Molecular Weight

275.23

Formula

C14H10FNO4
SMILES

CC(OC1=O)=CC(O)=C1C(/C=C/C2=CC=NC(F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPARγ/GR modulator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ/GR modulator 1PPARGlucocorticoid ReceptorPeroxisome proliferator-activated receptorsmetabolic diseasesdiabetesadiponectinleptinInhibitorinhibitorinhibit

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