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Cat. No.: HY-151963

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PPARγ/GR modulator 1

PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with K_is of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes.

For research use only. We do not sell to patients.

CAS No.: 3037963-50-8
Formula: C₁₄H₁₀FNO₄
Molecular Weight:275.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PPARγ/GR modulator 1 Chemical Structure

CAS No.: 3037963-50-8

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PPARγ

3.3 μM (Ki)

glucocorticoid receptor

33.6 μM (Ki)

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Mesenchymal stem cells	EC₅₀	2.2 μM Compound: 11	Induction of leptin biosynthesis in human BMMSC cells assessed as adiponectin level measured after 7 days by ELISA Induction of leptin biosynthesis in human BMMSC cells assessed as adiponectin level measured after 7 days by ELISA	[PMID: 36379105]
Mesenchymal stem cells	EC₅₀	2.9 μM Compound: 11	Induction of adiponectin biosynthesis in human BMMSC cells assessed as adiponectin level measured after 7 days by ELISA Induction of adiponectin biosynthesis in human BMMSC cells assessed as adiponectin level measured after 7 days by ELISA	[PMID: 36379105]

In Vitro

PPARγ/GR modulator 1 (compound 11) stimulates production of adiponectin and leptin in hBM-MSCs, with IC₅₀s of 2.87 and 2.82 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PPARγ/GR modulator 1 (compound 11) (25-50 mg/kg; p.o. for 5 d) reduces serum glucose levels, serum lactate levels, and serum adiponectin levels in STZ-induced mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5-week-old male C57BL/6J mice were injected with180 mg/kg of STZ^[1]
Dosage:

25, 50 mg/kg
Administration:

Orally administration for 5 days
Result:

Significant reduced serum glucose levels, serum lactate levels, and serum adiponectin levels.

Chemical Information

CAS No. 3037963-50-8
Molecular Weight 275.23
Formula C₁₄H₁₀FNO₄
SMILES

CC(OC1=O)=CC(O)=C1C(/C=C/C2=CC=NC(F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahn S, et, al. Discovery of PPARγ and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114927. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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