RK-0133114
RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD).
For research use only. We do not sell to patients.
- Formula: C26H30N4O3
- Molecular Weight:446.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MOLT-4 | GI50 |
2370 nM
Compound: R-26j; RK-0133114
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Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth with replenishment of medium with compound on day 4 and 7 and measured after 12 days by ATPlite assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth with replenishment of medium with compound on day 4 and 7 and measured after 12 days by ATPlite assay
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[PMID: 36882960] |
In Vitro
RK-0133114 shows no effect on the level of H3K9me2 in human umbilical cord blood derived erythroid progenitor 2 (HUDEP-2) cells and failed to increase fetal globins (HbF) in HUDEP-2 cells[1]. RK-0133114 (0.1 nM-100 μM) inhibits G9a with an IC50 value of 3.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 446.54
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Formula C26H30N4O3
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SMILES
CC1=C(C(N[C@H](CCC2CC2)C(NC3=CC=C(C=C3)C#N)=O)=O)NC(CC(C)(C4)C)=C1C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RK-0133114 Related Classifications
HY-152775A Related Classifications
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