Roridin H
Roridin H (Verrucarin H) is a cytostatic antibiotic present in the Myrothecium verrucaria strain and the marine-derived Myrothecium sp. TUF 02F6. The IC50 of Roridin H against mouse leukemia cells is 0.12 mM. Roridin H can be used in leukemia-related research.
For research use only. We do not sell to patients.
- CAS No.: 29953-50-2
- Formula: C29H36O8
- Molecular Weight:512.59
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.12 μM
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Cytotoxicity against murine leukemia L1210 cells by XTT method, incubated for 72 h.
Cytotoxicity against murine leukemia L1210 cells by XTT method, incubated for 72 h.
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17080680 |
In Vitro
Roridin H (compound 1) undergoes complete catalytic hydrogenation to form Octahydrororidin H[1].
Roridin H undergoes base-catalyzed hydrolysis, which cleaves the macrocyclic diester to produce Verrucarol and Myrothecinic acid[1].
Roridin H (72 h) potently inhibits the proliferation of mouse leukemia L1210 cells, with an IC50 of 0.12 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 29953-50-2
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Appearance Solid
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Molecular Weight 512.59
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Formula C29H36O8
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Color White to off-white
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SMILES
CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C(O5)C(C)OC5C/C(C)=C\6)=O)([H])O2)(COC6=O)CC1
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Synonyms
Verrucarin H
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Structure Classification
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Initial Source
Myrothecium verrucaria
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (290 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Roridin H Related Classifications
HY-N12908 Related Classifications
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