2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Bacterial Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor
  4. SAP 2.8 peptide

SAP 2.8 peptide is an antimicrobial peptide. SAP 2.8 peptide induces bacterial membrane rupture and permeabilization, triggers an increase in intracellular ROS production, and causes bacterial death. SAP 2.8 peptide inhibits bacterial biofilm formation and disrupts established biofilms. SAP 2.8 peptide reduces bacterial load in animal models. SAP 2.8 peptide can be used for research on bacterial infections, skin and soft tissue infections, and peritonitis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SAP 2.8 peptide

SAP 2.8 peptide Chemical Structure

CAS No. : 3100335-76-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

SAP 2.8 peptide Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SAP 2.8 peptide is an antimicrobial peptide. SAP 2.8 peptide induces bacterial membrane rupture and permeabilization, triggers an increase in intracellular ROS production, and causes bacterial death. SAP 2.8 peptide inhibits bacterial biofilm formation and disrupts established biofilms. SAP 2.8 peptide reduces bacterial load in animal models. SAP 2.8 peptide can be used for research on bacterial infections, skin and soft tissue infections, and peritonitis[1].

In Vitro

SAP 2.8 peptide (0-32 μg/mL; 1 h) dose-dependently induces intracellular reactive oxygen species (ROS) production in Staphylococcus aureus (ATCC 25923) and MRSA 6390, as detected by DCFH-DA fluorescence assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SAP 2.8 peptide Related Antibodies
In Vivo

SAP 2.8 peptide (2-4 mg/kg; local administration; once daily; for 7 consecutive days) significantly reduces the wound bacterial loads of S. aureus ATCC 25923 and MRSA 6390 in a mouse model of skin and soft tissue infection[1].
Single administration of SAP 2.8 peptide (2-4 mg/kg; i.p.; 1 h post-infection) significantly reduces systemic bacterial loads of S. aureus ATCC 25923 and MRSA 6390, as well as proinflammatory cytokine levels, in a mouse peritonitis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (skin and soft tissue infection model induced by Staphylococcus aureus ATCC 25923)[1]
Dosage: 2 mg/kg; 4 mg/kg
Administration: topical; daily; 7 days
Result: Significantly reduced S. aureus ATCC 25923 wound bacterial load, with log10 CFU/g values lower than the vehicle group's ~4.5 log10 CFU/g.
Animal Model: Mice (skin and soft tissue infection model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)[1]
Dosage: 2 mg/kg; 4 mg/kg
Administration: topical; daily; 7 days
Result: Significantly reduced MRSA 6390 wound bacterial load, with log10 CFU/g values lower than the vehicle group's ~7.5 log10 CFU/g.
Animal Model: Mice (systemic bacterial infection peritonitis model induced by Staphylococcus aureus ATCC 25923)[1]
Dosage: 2 mg/kg; 4 mg/kg
Administration: i.p.; single dose 1 hour post-infection
Result: Reduced S. aureus ATCC 25923 load by 1 to 2 logs in blood, kidney, liver, and lung compared to vehicle control.
Reduced bacterial load in blood, kidney, liver, and lung at 2 mg/kg compared to vehicle control.
Significantly lowered pro-inflammatory cytokine levels (IL-1β, IL-6) in kidney, lung, liver, and blood compared to vehicle control.
Animal Model: Mice (systemic bacterial infection peritonitis model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)[1]
Dosage: 2 mg/kg; 4 mg/kg
Administration: i.p.; single dose 1 hour post-infection
Result: Reduced MRSA 6390 load in blood, kidney, liver, and lung compared to vehicle control at 4 mg/kg.
Showed no significant difference in MRSA 6390 bacterial load compared to vehicle control at 2 mg/kg.
Significantly lowered pro-inflammatory cytokine levels (IL-6, TNF-α) in blood compared to vehicle control at 4 mg/kg.
Did not reduce cytokine levels significantly compared to vehicle control at 2 mg/kg.
Molecular Weight

2376.82

Formula

C114H154N38O16S2
CAS No.
Sequence

Arg-Cys-Trp-Lys-Arg-Trp-Trp-Arg-Trp-Trp-Lys-Arg-Cys-Trp-Arg (Disulfide bridge:Cys2-Cys13)
Sequence Shortening

RCWKRWWRWWKRCWR (Disulfide bridge:Cys2-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SAP 2.8 peptide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAP 2.8 peptide3100335-76-7BacterialReactive Oxygen Species (ROS)Interleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRreactive oxygen speciesmultidrug-resistant Staphylococcus aureusmouse peritonitis modelS. aureus ATCC 25923Staphylococcus aureusmethicillin-resistant Staphylococcus aureusmammalian cellspro-inflammatory cytokinemouse skin and soft tissue infection modelbacterial biofilmInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SAP 2.8 peptide
Cat. No.:
HY-P11819
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.