SAP 2.8 peptide
SAP 2.8 peptide is an antimicrobial peptide. SAP 2.8 peptide induces bacterial membrane rupture and permeabilization, triggers an increase in intracellular ROS production, and causes bacterial death. SAP 2.8 peptide inhibits bacterial biofilm formation and disrupts established biofilms. SAP 2.8 peptide reduces bacterial load in animal models. SAP 2.8 peptide can be used for research on bacterial infections, skin and soft tissue infections, and peritonitis.
For research use only. We do not sell to patients.
- CAS No.: 3100335-76-7
- Formula: C114H154N38O16S2
- Molecular Weight:2376.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SAP 2.8 peptide (0-32 μg/mL; 1 h) dose-dependently induces intracellular reactive oxygen species (ROS) production in Staphylococcus aureus (ATCC 25923) and MRSA 6390, as detected by DCFH-DA fluorescence assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Single administration of SAP 2.8 peptide (2-4 mg/kg; i.p.; 1 h post-infection) significantly reduces systemic bacterial loads of S. aureus ATCC 25923 and MRSA 6390, as well as proinflammatory cytokine levels, in a mouse peritonitis model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (skin and soft tissue infection model induced by Staphylococcus aureus ATCC 25923)[1]
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Dosage:2 mg/kg; 4 mg/kg
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Administration:topical; daily; 7 days
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Result:Significantly reduced S. aureus ATCC 25923 wound bacterial load, with log10 CFU/g values lower than the vehicle group's ~4.5 log10 CFU/g.
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Animal Model:Mice (skin and soft tissue infection model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)[1]
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Dosage:2 mg/kg; 4 mg/kg
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Administration:topical; daily; 7 days
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Result:Significantly reduced MRSA 6390 wound bacterial load, with log10 CFU/g values lower than the vehicle group's ~7.5 log10 CFU/g.
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Animal Model:Mice (systemic bacterial infection peritonitis model induced by Staphylococcus aureus ATCC 25923)[1]
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Dosage:2 mg/kg; 4 mg/kg
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Administration:i.p.; single dose 1 hour post-infection
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Result:Reduced S. aureus ATCC 25923 load by 1 to 2 logs in blood, kidney, liver, and lung compared to vehicle control.
Reduced bacterial load in blood, kidney, liver, and lung at 2 mg/kg compared to vehicle control.
Significantly lowered pro-inflammatory cytokine levels (IL-1β, IL-6) in kidney, lung, liver, and blood compared to vehicle control.
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Animal Model:Mice (systemic bacterial infection peritonitis model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)[1]
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Dosage:2 mg/kg; 4 mg/kg
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Administration:i.p.; single dose 1 hour post-infection
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Result:Reduced MRSA 6390 load in blood, kidney, liver, and lung compared to vehicle control at 4 mg/kg.
Showed no significant difference in MRSA 6390 bacterial load compared to vehicle control at 2 mg/kg.
Significantly lowered pro-inflammatory cytokine levels (IL-6, TNF-α) in blood compared to vehicle control at 4 mg/kg.
Did not reduce cytokine levels significantly compared to vehicle control at 2 mg/kg.
Chemical Information
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CAS No. 3100335-76-7
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Molecular Weight 2376.82
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Formula C114H154N38O16S2
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Sequence
Arg-Cys-Trp-Lys-Arg-Trp-Trp-Arg-Trp-Trp-Lys-Arg-Cys-Trp-Arg (Disulfide bridge:Cys2-Cys13)
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Sequence Shortening
RCWKRWWRWWKRCWR (Disulfide bridge:Cys2-Cys13)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAP 2.8 peptide Related Classifications
HY-P11819 Related Classifications
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- SAP 2.8 peptide
- 3100335-76-7
- Bacterial
- Reactive Oxygen Species (ROS)
- Interleukin Related
- TNF Receptor
- reactive oxygen species
- multidrug-resistant Staphylococcus aureus
- mouse peritonitis model
- S. aureus ATCC 25923
- Staphylococcus aureus
- methicillin-resistant Staphylococcus aureus
- mammalian cells
- pro-inflammatory cytokine
- mouse skin and soft tissue infection model
- bacterial biofilm
- Inhibitor
- inhibitor
- inhibit