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Art. -Nr.: HY-P11819

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SAP 2.8 peptide

SAP 2.8 peptide is an antimicrobial peptide. SAP 2.8 peptide induces bacterial membrane rupture and permeabilization, triggers an increase in intracellular ROS production, and causes bacterial death. SAP 2.8 peptide inhibits bacterial biofilm formation and disrupts established biofilms. SAP 2.8 peptide reduces bacterial load in animal models. SAP 2.8 peptide can be used for research on bacterial infections, skin and soft tissue infections, and peritonitis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3100335-76-7
Formel: C₁₁₄H₁₅₄N₃₈O₁₆S₂
Molecular Weight:2376.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

SAP 2.8 peptide Chemical Structure

CAS. Nr.: 3100335-76-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

SAP 2.8 peptide (0-32 μg/mL; 1 h) dose-dependently induces intracellular reactive oxygen species (ROS) production in Staphylococcus aureus (ATCC 25923) and MRSA 6390, as detected by DCFH-DA fluorescence assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SAP 2.8 peptide (2-4 mg/kg; local administration; once daily; for 7 consecutive days) significantly reduces the wound bacterial loads of S. aureus ATCC 25923 and MRSA 6390 in a mouse model of skin and soft tissue infection^[1].
Single administration of SAP 2.8 peptide (2-4 mg/kg; i.p.; 1 h post-infection) significantly reduces systemic bacterial loads of S. aureus ATCC 25923 and MRSA 6390, as well as proinflammatory cytokine levels, in a mouse peritonitis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice (skin and soft tissue infection model induced by Staphylococcus aureus ATCC 25923)^[1]
Dosage:

2 mg/kg; 4 mg/kg
Administration:

topical; daily; 7 days
Result:

Significantly reduced S. aureus ATCC 25923 wound bacterial load, with log₁₀ CFU/g values lower than the vehicle group's ~4.5 log₁₀ CFU/g.

Animal Model:

Mice (skin and soft tissue infection model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)^[1]
Dosage:

2 mg/kg; 4 mg/kg
Administration:

topical; daily; 7 days
Result:

Significantly reduced MRSA 6390 wound bacterial load, with log₁₀ CFU/g values lower than the vehicle group's ~7.5 log₁₀ CFU/g.

Animal Model:

Mice (systemic bacterial infection peritonitis model induced by Staphylococcus aureus ATCC 25923)^[1]
Dosage:

2 mg/kg; 4 mg/kg
Administration:

i.p.; single dose 1 hour post-infection
Result:

Reduced S. aureus ATCC 25923 load by 1 to 2 logs in blood, kidney, liver, and lung compared to vehicle control.
Reduced bacterial load in blood, kidney, liver, and lung at 2 mg/kg compared to vehicle control.
Significantly lowered pro-inflammatory cytokine levels (IL-1β, IL-6) in kidney, lung, liver, and blood compared to vehicle control.

Animal Model:

Mice (systemic bacterial infection peritonitis model induced by Methicillin-resistant Staphylococcus aureus (MRSA) 6390)^[1]
Dosage:

2 mg/kg; 4 mg/kg
Administration:

i.p.; single dose 1 hour post-infection
Result:

Reduced MRSA 6390 load in blood, kidney, liver, and lung compared to vehicle control at 4 mg/kg.
Showed no significant difference in MRSA 6390 bacterial load compared to vehicle control at 2 mg/kg.
Significantly lowered pro-inflammatory cytokine levels (IL-6, TNF-α) in blood compared to vehicle control at 4 mg/kg.
Did not reduce cytokine levels significantly compared to vehicle control at 2 mg/kg.

Chemical Information

CAS. Nr. 3100335-76-7
Molecular Weight 2376.82
Formel C₁₁₄H₁₅₄N₃₈O₁₆S₂
Sequence

Arg-Cys-Trp-Lys-Arg-Trp-Trp-Arg-Trp-Trp-Lys-Arg-Cys-Trp-Arg (Disulfide bridge:Cys2-Cys13)
Sequence Shortening

RCWKRWWRWWKRCWR (Disulfide bridge:Cys2-Cys13)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Asmamaw D, et al. Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections. ACS Med Chem Lett. 2025 May 12;16(6):1114-1123. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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SAP 2.8 peptide

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Alle TNF Receptor Isoform-spezifische Produkte anzeigen