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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
346 Results for "
low affinity
" in MedChemExpress (MCE) Product Catalog:
Products (346)
346 Results for "low affinity" in MCE Product Catalog:
Referencia número: HY-P7783U
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.; ≥ 95%, as determined by HPLC.
Synonyms: CSF2RA; GMCSFR-Alpha; Prev. CSF2R; CDw116; AlphaGMR; CSF2RY; CD116; Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain; Colony Stimulating Factor 2 Receptor, Alpha, low-affinity (Granulocyte-Macrophage); CSF2RAX; Granulocyte-Macrophage
Species:
Human
Source:
HEK293
Referencia número: HY-P992053
Target:
Áreas de investigación:
Synonyms: PF-06372865; CVL-865
Target:
Áreas de investigación:
Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy .
Referencia número: HY-P7301
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Rat
Source:
CHO
Referencia número: HY-P72748
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-Binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Human
Source:
HEK293
Referencia número: HY-P72676
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Human
Source:
HEK293
Referencia número: HY-P74320
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-Binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Rat
Source:
HEK293
Referencia número: HY-P74321
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-Binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Mouse
Source:
HEK293
Referencia número: HY-P75699
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Rat
Source:
HEK293
Referencia número: HY-P75700
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Rat
Source:
P. pastoris
Referencia número: HY-P76854
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Rhesus Macaque
Cynomolgus
Source:
HEK293
Referencia número: HY-P76855
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Cynomolgus
Rhesus Macaque
Source:
P. pastoris
Referencia número: HY-P700049AF
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Human
Source:
E. coli
Referencia número: HY-P700174AF
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Mouse
Source:
E. coli
Referencia número: HY-P81202
Synonyms: FCG3A_HUMAN; low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: D16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3.
Referencia número: HY-P811546
Synonyms: FCG3A_HUMAN; low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: D16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3.
Synonyms: GT-2331
Target:
Áreas de investigación:
Cipralisant (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant has the potential for attention-deficit hyperactivity disorder research . Cipralisant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: GT-2331 maleate
Target:
Áreas de investigación:
Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research . Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Referencia número: HY-115862
No. CAS: 53439-81-9
Target:
Áreas de investigación:
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM .
Target:
Áreas de investigación:
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
