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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
346 Results for "
low affinity
" in MedChemExpress (MCE) Product Catalog:
Products (346)
346 Results for "low affinity" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P7267
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Human
Source:
CHO
1
1 Cited Publications
Cat. No.: HY-P75698
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; low-affinity Platelet Factor I
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Target:
Domaines de recherche:
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
1
1 Cited Publications
Cat. No.: HY-18006
CAS No.: 177707-12-9
Target:
Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis
Domaines de recherche:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, neurokinin-1 (NK1) receptor antagonist with IC50 of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK2, NK3 receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .
1
1 Cited Publications
Cat. No.: HY-W082785A
CAS No.: 24533-47-9
Target:
TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)
Domaines de recherche:
Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
Synonyms: ACR16; ASP2314; FR310826
Target:
Domaines de recherche:
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
Cat. No.: HY-132189
CAS No.: 197509-46-9
Target:
Domaines de recherche:
Laniquidar is a non-competitive P-gp inhibitor with an IC50 of 0.51 μM. Laniquidar binds to the P-gp transporter with high affinity and exhibits low activity as a substrate. Laniquidar is applicable to epilepsy-related research .
Cat. No.: HY-W001909
CAS No.: 532-12-7
Category:
Alkaloids Pyrrole Alkaloids Nicotiana tabacum L. Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Solanaceae Extract
Target:
Cat. No.: HY-P9973
CAS No.: 1531589-13-5
Synonyms: DLX1008; ESBA 1008; RTH258
Target:
Domaines de recherche:
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM) .
Target:
Domaines de recherche:
CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b) .
Target:
Domaines de recherche:
Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors .
Cat. No.: HY-W009234
CAS No.: 2004-07-1
Synonyms: 6-Chloroguanosine
Target:
Domaines de recherche:
6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (Ki: 253.1 μM) .
Synonyms: AWD 131-138
Target:
Domaines de recherche:
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
Cat. No.: HY-135239
CAS No.: 192140-58-2
Cat. No.: HY-W001909S
CAS No.: 66148-17-2
Target:
Target:
Domaines de recherche:
GFP16 is a low affinity antiprion compound. GFP16 can be used for research of antiprion drug discovery .
Cat. No.: HY-137103
CAS No.: 176767-94-5
Cat. No.: HY-14953R
CAS No.: 188116-07-6
Synonyms: AWD 131-138 (Standard)
Target:
Domaines de recherche:
Imepitoin (Standard) is the analytical standard of Imepitoin. This product is intended for research and analytical applications. Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
