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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
392 Results for "
Chelators
" in MedChemExpress (MCE) Product Catalog:
Products (392)
392 Results for "Chelators" in MCE Product Catalog:
Cat. No.: HY-149418
CAS No.: 2925457-33-4
Target:
Research Areas:
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe 2+ and Cu 2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
Cat. No.: HY-156991
CAS No.: 1407166-70-4
Synonyms: NODA-GA-NHS ester
Research Areas:
NODAGA-NHS (NODA-GA-NHS ester) is the activated ester form of the NODAGA chelator. NODAGA-NHS conjugates with Trastuzumab (HY-P9907) to form NODAGA-Trastuzumab, a conjugate that can chelate 64Cu for the preparation of radiotracers. NODAGA-NHS covalently binds to the amino group of lactosamine derivatives to form radiotracer precursors. [ 64Cu]NODAGA-trastuzumab enables PET imaging of tumors expressing HER2. NODAGA-NHS is used in studies of HER2-positive breast cancer and ovarian adenocarcinoma .
PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
Cat. No.: HY-164575C
Research Areas:
(S)-NH2-NODAGA hydrochloride is the S isomer of NH2-NODAGA hydrochloride (HY-164575B). NH2-NODAGA hydrochloride is an amino-modified NODAGA-type bifunctional chelator, specifically designed for amidation coupling with targeting ligands via squaric acid (SA), followed by coordination with radionuclides (e.g., 68Ga, 177Lu). NH2-NODAGA hydrochloride can be coupled with diethyl squarate to form a PSMA inhibitor conjugate, which is used in prostate cancer research.
Cat. No.: HY-174358A
CAS No.: 39927-08-7
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HOOC-PEG2000-COOH is a dicarboxyl-terminated polyethylene glycol and calcium ion chelator. HOOC-PEG2000-COOH inhibits platelet aggregation and contraction while promoting fibrinolysis and blood clot dissolution. HOOC-PEG2000-COOH can serve as a coating for superparamagnetic iron oxide nanoparticles in nanovaccine formulations, and as a bifunctional linker in pH-sensitive conjugates for siRNA delivery liposomes. HOOC-PEG2000-COOH can be used in research on thrombosis and atherosclerosis .
Cat. No.: HY-P11638
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Cat. No.: HY-P11638A
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Cat. No.: HY-P1997
CAS No.: 34787-28-5
Synonyms: Desferrichrome; DFC; N-Desferriferrichrome
Cat. No.: HY-120475B
CAS No.: 1232840-87-7
Synonyms: ATH434 free base
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PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD) .
Cat. No.: HY-158119A
CAS No.: 3036415-37-6
Synonyms: Felivotide mopaxetan
PSMA-trillium (Felivotide mopaxetan) is a PSMA-targeted molecule that contains a highly specific PSMA-binding motif, an albumin-binding domain optimized for tumor uptake and retention, and a Macropa chelator conjugated to the α-emitter 225Ac. PSMA-trillium binds to albumin to prolong plasma retention time and binds to PSMA via its specific motif. 225Ac-PSMA-Trillium exhibits dose-dependent inhibition of LNCaP tumor growth in mice. PSMA-trillium can be used in research related to prostate cancer and metastatic castration-resistant prostate cancer .
Synonyms: Desferrioxamine B mesylate (Standard); DFOM (Standard)
Target:
Reference Standards Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
Cat. No.: HY-P10781
CAS No.: 3056440-83-3
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Cat. No.: HY-W035904
CAS No.: 539-80-0
Synonyms: Cycloheptatrienone
Category:
Ketones, Aldehydes, Acids Other Diseases Plants Other Families Extract Disease Research Fields
Target:
Cat. No.: HY-W087187G
CAS No.: 1375475-53-8
Cat. No.: HY-W127790
CAS No.: 52746-49-3
Cat. No.: HY-W400427
CAS No.: 59-56-3
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α-D-Glucose-1-phosphate is a derivative of D-glucose (HY-B0389). α-D-Glucose-1-phosphate serves as a starting material for glucuronic acid synthesis. Glucuronic acid acts as a Ca 2+ chelator and also functions as a biosynthetic substrate for the production of linear maltooligosaccharides or α,α-trehalose. α-D-Glucose-1-phosphate can be used as a cytostatic compound, Antibiotic, and immunosuppressant essential for heart disease management. α-D-Glucose-1-phosphate is applicable to the research of heart disease .
Cat. No.: HY-W718262
CAS No.: 49608-51-7
Synonyms: (Rac)-CGP 52547
Target:
Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia .
Cat. No.: HY-178271
CAS No.: 147597-66-8
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Research Areas:
P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
