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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
GTPase activity
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "GTPase activity" in MCE Product Catalog:
Cat. No.: HY-173054
CAS No.: 3099249-36-9
FtsZ-IN-12 (Compound 16e) is the inhibitor for filamentous temperature-sensitive mutant Z (FtsZ) that promotes the polymerization of FtsZ protein, inhibits its GTPase activity, thereby interfering with bacterial cell division process. FtsZ-IN-12 exhibits boardspectrum antibacterial activity that inhibits B. subtilis ATCC9372, B. pumilus CMCC63202, S. aureus ATCC25923, E. coli BW25113 and A. baumannii ATCC19606 with MIC of 0.062-1 μg/mL. FtsZ-IN-12 inhibits the formation of bacterial biofilms and exhibits a clearing effect on mature biofilms. FtsZ-IN-12 exhibits bactericidal activity without hemolytic toxicity to mammalian red blood cells (15 mg/kg) .
Cat. No.: HY-148022
CAS No.: 82585-91-9
Target:
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NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC50 of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers .
Cat. No.: HY-168630
CAS No.: 3042897-74-2
FtsZ-IN-11 (compound B6) is a FtsZ inhibitor with the IC50 of 235 μM against XooFtsZ. FtsZ-IN-11 can interact with XooFtsZ and inhibit its GTPase activity, leading to bacterial cell elongation and even death .
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N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer .
Cat. No.: HY-149223
FtsZ-IN-5 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-5 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-5 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-5 shows low hemolytic activity and cytotoxicity to mammalian cells .
Cat. No.: HY-149224
FtsZ-IN-6 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-6 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-6 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-6 shows low hemolytic activity and cytotoxicity to mammalian cells .
Cat. No.: HY-149225
FtsZ-IN-7 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-7 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-7 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-7 shows low hemolytic activity and cytotoxicity to mammalian cells .
Cat. No.: HY-149226
FtsZ-IN-8 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-8 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-8 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-8 shows low hemolytic activity and cytotoxicity to mammalian cells .
Cat. No.: HY-P10650
CAS No.: 1588388-60-6
Cat. No.: HY-110354R
CAS No.: 1094451-90-7
Synonyms: G28UCM (Standard)
Research Areas:
UCM05 (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections [1][2][3].
Cat. No.: HY-187991
FtsZ-IN-16 is a curcumin derivative and also an inhibitor of XooFtsZ, with an EC50 of 3.74 μg/mL against Xoo. FtsZ-IN-16 targets the FtsZ residues LEU71, GLY74, GLY110 and THR111 of Xanthomonas oryzae pv. oryzae, thereby blocking GTPase (GTPase) activity and polymerization. FtsZ-IN-16 can be used in studies related to rice bacterial blight .
Cat. No.: HY-184059
CAS No.: 140674-77-7
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Tyrphostin AG 537 is a dynamin I GTPase inhibitor with an IC50 of 1.7 μM. Tyrphostin AG 537 inhibits phospholipid-stimulated GTPase activity without competing for the GTP domain or PH domain of dynamin I. Tyrphostin AG 537 inhibits spermidine-induced autoactivation of pro-plasma hyaluronan-binding protein (pro-PHBP) with an IC50 of 0.018 μM. Tyrphostin AG 537 can be used in inflammation-related research .
Cat. No.: HY-107545R
CAS No.: 1128165-88-7
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Dynole 34-2 (Standard) is the analytical standard of Dynole 34-2 (HY-107545). This product is intended for research and analytical applications. Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) .
Cat. No.: HY-121434A
CAS No.: 49720-72-1
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N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine tartrate is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine tartrate can activate the GTPase activity of microtubules and can be used for the research of cancer .
Cat. No.: HY-111549R
CAS No.: 369631-68-5
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Bragsin1 (Standard) is the analytical standard of Bragsin1 (HY-111549). This product is intended for research and analytical applications. Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity .
Cat. No.: HY-181933
CAS No.: 339025-18-2
Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM .
Cat. No.: HY-W616426
CAS No.: 13637-37-1
3,3'-Bi[1H-indole] is a MtbFtsZ inhibitor. 3,3'-Bi[1H-indole] inhibits the GTPase activity of MtbFtsZ. 3,3'-Bi[1H-indole] increases the cell length of Mycobacterium smegmatis and Bacillus subtilis. 3,3'-Bi[1H-indole] can be used in the research of tuberculosis .
Cat. No.: HY-184334
FtsZ-IN-15 is an inhibitor targeting the FtsZ protein of Xanthomonas oryzae pv. oryzae (Xoo) and a cell division inhibitor. FtsZ-IN-15 specifically binds to key residues of XooFtsZ, inhibits its GTPase activity and disrupts its polymerization. FtsZ-IN-15 induces cell elongation of Xanthomonas oryzae pv. oryzae and exhibits significant antibacterial activity against this strain. FtsZ-IN-15 shows good control efficacy against rice bacterial blight and can be used in relevant research on rice bacterial blight .
Cat. No.: HY-181978
CAS No.: 844464-54-6
GIT1-IN-1 is an inhibitor of ARF GTPase-activating protein 1 (GIT1) with a KD of 6.2 μM. GIT1-IN-1 induces apoptosis (apoptosis) in liver and colon cancer cells, arrests the cell cycle at the G2/M phase, and inhibits cell proliferation, colony formation and migration. GIT1-IN-1 inhibits the activities of MEK and ERK, reduces the expression level of cyclin D1, and stabilizes cyclin B1 protein in liver and colon cancer cells. GIT1-IN-1 can be used in the research of liver cancer and colon cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
