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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
LIMK1
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "LIMK1" in MCE Product Catalog:
Cat. No.: HY-174229
Target:
Research Areas:
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion [1].
Cat. No.: HY-178122
Research Areas:
THNAN69 is a PROTAC degrader targeting LIMK2, which efficiently degrades ectopically expressed EGFP-LIMK2 in live HuCCT1 cells with a DC50 of 1 nM. THNAN69 induces isoform-specific ubiquitin-mediated degradation of LIMK2 by recruiting the CRBN E3 ligase, forming a stable ternary complex with LIMK2 and CRBN; this degradation process depends on the activity of cullin-RING ligase. THNAN69 does not reduce phosphorylated cofilin levels, as LIMK1 can compensate for the loss of LIMK2; it also stimulates compensatory activation of the Rho signaling pathway including PAK1/2 and ROCK1/2. THNAN69 serves as a selective chemical probe for dissecting the LIMK2 isoform-dependent biological mechanisms. THNAN69 can be used in the research of cholangiocellular carcinoma and acute lymphoblastic leukemia [1].
Cat. No.: HY-123345
CAS No.: 1661846-05-4
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CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM [1].
Cat. No.: HY-175656
CAS No.: 3107269-84-8
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Research Areas:
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders [1].
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Research Areas:
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 [1].
Cat. No.: HY-N10868
CAS No.: 956707-04-3
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Target:
Cat. No.: HY-159897
Research Areas:
PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC50: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD50: >500 mg/kg for mice (p.o.) [1].
Cat. No.: HY-W150222
CAS No.: 4994-89-2
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Research Areas:
LIMK1-IN-3 is a LIMK1 inhibitor with an IC50 of 4.4 μM. LIMK1-IN-3 shows potential for use in cancer-related research [1].
Cat. No.: HY-P705847
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIMK1; LIMK-1; LIM Domain Kinase 1; LIM Motif-Containing Protein Kinase; LIMK; Uncharacterized Protein LIMK1
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P701792
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIMK1; LIMK-1; LIM Domain Kinase 1; LIM Motif-Containing Protein Kinase; LIMK; Uncharacterized Protein LIMK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701793
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIMK1; LIMK-1; LIM Domain Kinase 1; LIM Motif-Containing Protein Kinase; LIMK; Uncharacterized Protein LIMK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-12659B
CAS No.: 2319882-48-7
Target:
Research Areas:
LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research [1] .
Cat. No.: HY-168908
CAS No.: 2838087-03-7
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Research Areas:
LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer [1].
Cat. No.: HY-125444
CAS No.: 1622059-04-4
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Research Areas:
TH251 is a LIMK1 and LIMK2 inhibitor with IC50s of 52 nM and 47 nM against LIMK1 and LIMK2, respectively. TH251 binds to inactive αC-out and DFG-out LIMK1 conformations, inhibits unphosphorylated LIMK1 and LIMK2 enzymatic activity, and exhibits unchanged potency despite PAK-mediated phosphorylation of either kinase. TH251 can be used for the research of cancers, glaucoma, and CNS diseases [1] .
Cat. No.: HY-183941
CAS No.: 713080-84-3
SPU-106 is a p21 activated kinase 4 (PAK4) inhibitor with a target IC50 of 21.36 μM. SPU-106 selectively binds to the C-terminal kinase domain of PAK4 to inhibit its kinase activity. SPU-106 inhibits the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. SPU-106 inhibits invasion of gastric cancer cells and lacks cytotoxicity against cancer cells. SPU-106 can be used for the research of gastric cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
