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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
PAH
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "PAH" in MCE Product Catalog:
Target:
Áreas de investigación:
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH) .
Synonyms: ACT-064992-d4
Target:
Áreas de investigación:
CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .
Referencia número: HY-14184R
No. CAS: 441798-33-0
Synonyms: ACT-064992 (Standard)
Áreas de investigación:
Macitentan (Standard) is the analytical standard of Macitentan. This product is intended for research and analytical applications. Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .
Referencia número: HY-A0124
No. CAS: 62989-33-7
Synonyms: (6R)-BH4; (6R)-Tetrahydro-L-biopterin
Target:
Áreas de investigación:
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .
Referencia número: HY-W016103
No. CAS: 86-48-6
Category:
Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields
Target:
Referencia número: HY-A0124AR
No. CAS: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)
Áreas de investigación:
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .
Referencia número: HY-174416
No. CAS: 1824647-09-7
Target:
Áreas de investigación:
Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) .
Referencia número: HY-N11222
No. CAS: 151109-67-0
Synonyms: C9 carnitine
Category:
Target:
Target:
Áreas de investigación:
Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED) .
Referencia número: HY-W013570S
No. CAS: 93951-97-4
Synonyms: Acenaphthylene-d8
Áreas de investigación:
Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .
Target:
Áreas de investigación:
Phenanthrene (Standard) is the analytical standard of Phenanthrene. This product is intended for research and analytical applications. Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
Referencia número: HY-W017708
No. CAS: 217-59-4
Target:
Áreas de investigación:
Triphenylene is a highly symmetrical polycyclic aromatic hydrocarbon. Triphenylene shows no carcinogenic activity in mouse skin application experiments. Triphenylene can be used as a drug intermediate for the synthesis of triphenyl polycyclic aromatic hydrocarbons (PAHs) .
Referencia número: HY-144856S1
No. CAS: 2747956-15-4
Synonyms: (6R)-BH4-d3; (6R)-Tetrahydro-L-biopterin-d3
Referencia número: HY-W012278
No. CAS: 56-55-3
Synonyms: Tetraphene
Áreas de investigación:
Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation .
Referencia número: HY-W777456
No. CAS: 1189955-53-0
Referencia número: HY-W011845R
No. CAS: 57-97-6
Synonyms: 7,12-DMBA (Standard); 7,12-Dimethylbenzanthracene (Standard)
Target:
Áreas de investigación:
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
Referencia número: HY-177948
No. CAS: 3052947-04-0
Áreas de investigación:
GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
