144 Results for "

cellular responses

" in MedChemExpress (MCE) Product Catalog:
Products (144)

144 Results for "cellular responses" in MCE Product Catalog:

Cat. No.: HY-P99361
CAS No.: 1062149-33-0
Synonyms: PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)

Target:  

TNF Receptor

Research Areas:  

Cancer

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .
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Cat. No.: HY-12326
CAS No.: 54447-84-6
Synonyms: Cyclic diadenylate; Cyclic-di-AMP
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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Cat. No.: HY-D0307A
CAS No.: 915-67-3
Synonyms: Acid Red 27; Azorubin S; FD & C Red Dye No. 2
Amaranth is an organic azo dye. Amaranth inhibits cellular immune response. Amaranth can be used as a food additive .
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Cat. No.: HY-B0389S16
CAS No.: 40762-22-9
Synonyms: Glucose-1-13C; D-(+)-Glucose-1-13C; Dextrose-1-13C
D-Glucose-1- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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Cat. No.: HY-101092B
CAS No.: 250643-56-2
QS-21-Xyl is a active component of QS-21 (HY-101092A). QS-21 is a natural vaccine adjuvant and induces a balanced Th1/Th2 immune response, particularly cellular immunity .
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Cat. No.: HY-108626
CAS No.: 1345964-89-7
Purity:  99.59%
Synonyms: NCGC84
Research Areas:  

Neurological Disease

ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively .
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Cat. No.: HY-113313S1
Purity:  99.78%
Aldosterone-d7 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .
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Cat. No.: HY-B2218D
CAS No.: 1309-42-8
Synonyms: Magnesium dihydroxide, 99%(KT)
Magnesium hydroxide (Magnesium dihydroxide), 99%(KT) is an orally effective antacid. Magnesium hydroxide, 99%(KT) can form a local strongly alkaline microenvironment, reduce ATP production by consuming H +, and hydrolyze cellular phospholipids to disrupt the cellular integrity of microorganisms, thus exhibiting antibacterial activity. Magnesium hydroxide, 99%(KT) downregulates the generation of inflammatory macrophages to alleviate inflammatory responses. Magnesium hydroxide, 99%(KT) can be used in research related to acid peptic diseases and chronic wound infections .
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Cat. No.: HY-B0389S5
CAS No.: 18991-62-3
Synonyms: Glucose-d2; D-(+)-Glucose-d2; Dextrose-d2
D-Glucose-d2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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Cat. No.: HY-B0389S6
CAS No.: 66034-51-3
Synonyms: Glucose-d7; D-(+)-Glucose-d7; Dextrose-d7
D-Glucose-d77 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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Cat. No.: HY-162405
CAS No.: 2949393-27-3
STAT6-IN-12 is a potent STAT6 inhibitor with an IC50 of 50 nM. STAT6-IN-12 also inhibits Smad2/3 with an IC50 of 68 nM. STAT6-IN-12 inhibits TGFβ-dependent Smad2/3 signaling pathway, IL-4-dependent STAT6 signaling pathway, and cellular inflammatory responses. STAT6-IN-12 can be used for the research of inflammation .
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Cat. No.: HY-B1511R
CAS No.: 60-92-4
Synonyms: Cyclic adenosine monophosphate (Standard); Adenosine cyclic 3', 5'-monophosphate (Standard); cAMP (Standard)
Research Areas:  

Cancer

Cyclic AMP (Standard) is the analytical standard of Cyclic AMP. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .
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Cat. No.: HY-178208
Research Areas:  

Cancer

MDOLL-0286 is a selective Poly(ADP-ribose) Glycohydrolase (PARG) (ARH3) inhibitor with an IC50 of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer .
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Cat. No.: HY-N7513
CAS No.: 2380-78-1
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol, and belongs to the class of phenolic organic compounds. Homovanillyl alcohol alleviates cellular oxidative stress and inflammatory responses by scavenging free radicals, inhibiting the phosphorylation of the p38 and JNK MAP kinase pathways, as well as suppressing NF-κB-driven transcription and nuclear translocation. It can be used in studies related to cardiovascular diseases and allergic asthma .
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Cat. No.: HY-W010410
CAS No.: 3391-86-4
Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling .
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Cat. No.: HY-P99431
CAS No.: 2489390-15-8
Synonyms: Alomfilimab; SAR 445256

Target:  

CD28

Research Areas:  

Inflammation/Immunology Cancer

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 + TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .
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Cat. No.: HY-101954
CAS No.: 475650-36-3
Synonyms: ORI-9020; SB-9000
Target:  

HBV

Research Areas:  

Infection

Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses .
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Cat. No.: HY-101954A
CAS No.: 2172788-92-8
Purity:  99.04%
Synonyms: ORI-9020 ammonium; SB-9000 ammonium
Target:  

HBV

Research Areas:  

Infection Inflammation/Immunology

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses .
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Cat. No.: HY-172741
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease

Dioctanoyl PI(3,5)P2 sodium is a synthetic analog of PI(3,5)P2 (a natural phosphatidylinositol). Phosphatidylinositol phosphates (PIPs) are intracellular amphiphilic molecules implicated in numerous cellular responses including growth, division, movement, differentiation, neuro-exocytosis, and survival .
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Cat. No.: HY-W145481A
CAS No.: 11078-30-1
Synonyms: Carob galactomannan
D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .
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