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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
212 Results for "
microsomal
" in MedChemExpress (MCE) Product Catalog:
Products (212)
212 Results for "microsomal" in MCE Product Catalog:
Cat. No.: HY-115354
CAS No.: 30896-57-2
Target:
Research Areas:
4-Hydroxy alprazolam is a metabolite of Alprazolam. Alprazolam is metabolized primarily by hepatic microsomal oxidation, yielding 4-Hydroxy alprazolam .
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CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo .
Cat. No.: HY-100333
CAS No.: 863491-70-7
Research Areas:
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
Cat. No.: HY-U00070
CAS No.: 481658-94-0
Synonyms: CP742033; Slentrol
Research Areas:
Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.
Synonyms: Methyl-IQ
Target:
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Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits .
Cat. No.: HY-B0816
CAS No.: 80844-07-1
Target:
Etofenprox is an orally active non-ester pyrethroid insecticide. Etofenprox induces toxicity against many pest insects, including Diptera rather than mammalian and fish. Etofenprox has a liver tumor-promoting activity in rats accompanied with microsomal ROS production increase. Etofenprox can be used in agricultural pest control and malaria research .
Cat. No.: HY-119220
CAS No.: 594842-13-4
Synonyms: JTT-130
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Granotapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces the absorption of cholesterol and triglycerides by inhibiting MTP. Granotapide can be used in the research of coronary artery disease, obesity, diabetes mellitus and hypertension .
Cat. No.: HY-19622
CAS No.: 1221971-47-6
Target:
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PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC50 of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro .
Cat. No.: HY-162387
CAS No.: 2171000-87-4
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UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice .
Cat. No.: HY-149202
Purity: 99.62%
Target:
Research Areas:
UT-11 is a potent and blood-brain barrier-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively .
Research Areas:
CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools .
Cat. No.: HY-P2961
CAS No.: 50812-37-8
Target:
Research Areas:
Glutathione S-transferase is a phase II metabolic enzyme composed of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses multiple catalytic activities, including catalytic detoxification and thiol transfer, as well as molecular chaperone functions. The Glutathione S-transferase isoform GSTP1 is highly expressed in malignant tumors and serves as a tumor biomarker .
Cat. No.: HY-U00270
CAS No.: 186390-35-2
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CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.
Target:
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Deschlorodemethyldiazepam is a benzodiazepines compound. Deschlorodemethyldiazepam can be hydroxylated in vitro by liver microsomal enzymes obtained from rats or mice .
Cat. No.: HY-137391
CAS No.: 15833-07-5
Target:
Research Areas:
2-Bromoestradiol is a estrogen 2-hydroxylase inhibitor. 2-Bromoestradiol decreases irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins .
Cat. No.: HY-133798
CAS No.: 583840-03-3
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Research Areas:
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM .
Cat. No.: HY-121088
CAS No.: 348148-51-6
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Research Areas:
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability .
Cat. No.: HY-113955A
CAS No.: 1262769-98-1
Research Areas:
CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo .
Target:
Research Areas:
Vitamin K1 2,3-epoxide is an inactive metabolite form of Vitamin K1 (HY-N0684), which is reduced to active vitamin by microsomal epoxide reductase in the vitamin K epoxide cycle. Vitamin K1 2,3-epoxide is involved in blood clotting .
Cat. No.: HY-116630
CAS No.: 403989-79-7
Synonyms: JNJ-16269110
Research Areas:
Usistapide (JNJ-16269110) is a microsomal triglyceride transfer protein (MTP) inhibitor. Usistapide is promising for research of obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
