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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
588 Results for "
stem+cell
" in MedChemExpress (MCE) Product Catalog:
Products (588)
588 Results for "stem+cell" in MCE Product Catalog:
Cat. No.: HY-P3483A
Research Areas:
Cat. No.: HY-P990851
Target:
Research Areas:
Cat. No.: HY-W011338R
CAS No.: 85-68-7
Research Areas:
Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .
Cat. No.: HY-W653962
CAS No.: 2726926-25-4
Cat. No.: HY-K6022
MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation. This product is compatible with a wide range of cell types, including stem cell colonies, primary cells, neural cells, and organoids, and is particularly well suited for gentle yet effective dissociation of brain organoids and other complex 3D structures.
Cat. No.: HY-10182AR
CAS No.: 1797989-42-4
Synonyms: CHIR-99021 monohydrochloride (Standard); CT99021 monohydrochloride (Standard)
Laduviglusib (monohydrochloride) (Standard) is the analytical standard of Laduviglusib (monohydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy .
Cat. No.: HY-103701R
CAS No.: 23313-12-4
Synonyms: 2-Phospho-L-ascorbic acid (Standard); LAA2P (Standard)
Target:
Synonyms: 108600
Research Areas:
ON 108600 (108600) is a CK2 (CK2α1: IC50 = 50 nM; CK2α2 = 5 nM), TNIK (IC50 = 5 nM) and DYRK (DYRK1A: IC50 = 16 nM; DYRK1B = 7 nM; DYRK2: = 28 nM). ON 108600 suppresses the growth of CD44high/CD24low breast cancer stem cell (BCSC) populations, induces G2/M arrest and apoptosis in triple negative breast cancer (TNBC) cells, and inhibits tubulin polymerization. ON 108600 can be used for the study of chemotherapy-resistant and metastatic TNBC .
Cat. No.: HY-173369
Research Areas:
PROTAC MAGL degrader-1 is an orally active, moderately blood-brain barrier permeable bifunctional PROTAC (DC50: 60.28 nM) that possesses MAGL degradation activity alongside MDM2 inhibitory activity. PROTAC MAGL degrader-1 recruits E3 ubiquitin ligase MDM2 to mediate ubiquitination of MAGL and subsequent proteasomal degradation. PROTAC MAGL degrader-1 blocks the interaction between MDM2 and P53 and upregulates the expression of tumor suppressor protein P53. PROTAC MAGL degrader-1 is applicable for research on glioblastoma stem cells, melanoma and breast cancer .
Cat. No.: HY-181074
Target:
Research Areas:
Tubulin polymerization-IN-88 is a tubulin inhibitor that blocks tubulin polymerization, leading to microtubule destabilization and disruption of the mitotic spindle. Tubulin polymerization-IN-88 induces G2/M phase arrest and apoptosis in cancer cells, and inhibits cancer cell migration and self-renewal of cancer stem cells. It exhibits in vitro anti-proliferative activity against cancer cells with selectivity over normal cells. Tubulin polymerization-IN-88 also demonstrates in vivo anti-cancer activity without significant toxicity. Tubulin polymerization-IN-88 is applicable for research on glioblastoma, lung cancer, endometrial cancer, ovarian cancer, and leukemia .
Cat. No.: HY-181560
CAS No.: 2759011-75-9
Research Areas:
SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .
Cat. No.: HY-W133907
CAS No.: 55566-30-8
Research Areas:
Tetrakis (hydroxymethyl) phosphonium sulfate is a protein crosslinker and hydrogel modifier. Tetrakis (hydroxymethyl) phosphonium sulfate covalently binds to primary and secondary amines of amino acids or proteins via a Mannich-type reaction, thereby constructing stable crosslinking bonds between protein molecules. Tetrakis (hydroxymethyl) phosphonium sulfate not only regulates the gelation time and storage modulus of recombinant elastin-like protein hydrogels, but also exhibits excellent cytocompatibility, and supports the differentiation and growth of embryonic stem cells and neural cells in a three-dimensional encapsulation environment. Tetrakis (hydroxymethyl) phosphonium sulfate is suitable for protein-based hydrogel systems, especially for applications related to cell encapsulation .
Cat. No.: HY-W714048
Synonyms: CHIR-99021-d4; CT99021-d4
Cat. No.: HY-W747491
CAS No.: 1365620-36-5
Triclosan- 13C12 is 13C labeled Triclosan (HY-B1119). Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
Cat. No.: HY-K6301
MCE Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit is a standardized culture system specifically designed to recapitulate the developmental processes and functional features of the human cerebral cortex through forebrain ventralization-based signaling regulation. By sequentially activating the Wnt/β-catenin pathway and gradually inhibiting BMP/Smad signaling, this system efficiently drives human pluripotent stem cells (PSC) to differentiate into high-purity glutamatergic neurons (VGLUT1/2+ > 85%), while simultaneously promoting the formation of Pax6+/BLBP+ radial glial cells that establish a biomimetic ventricular-zone–like structure.
Cat. No.: HY-P71539
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 Complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Human
Source:
E. coli
Cat. No.: HY-P71830
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 Complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Mouse
Source:
P. pastoris
Cat. No.: HY-P705423
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 Complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
