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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
588 Results for "
stem+cell
" in MedChemExpress (MCE) Product Catalog:
Products (588)
588 Results for "stem+cell" in MCE Product Catalog:
Cat. No.: HY-P705424
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 Complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Mouse
Source:
HEK293
Cat. No.: HY-138195
CAS No.: 1361198-79-9
NEO212 is an orally active, blood-brain barrier permeable conjugate of Temozolomide (TMZ) (HY-17364) and Perillyl Alcohol (POH) (HY-N7000), with potent anticancer activity. NEO212 overcomes classical TMZ resistance and DNA alkylation by depleting MGMT. By inhibiting the FAK/Src signaling pathway, NEO212 reduces the production of MMP2 and MMP9, induces mesenchymal-epithelial transition, and inhibits the migration, invasion and tumor progression of glioma stem cells. NEO212 disrupts autophagy flux to enhance mitochondrial apoptosis; it induces differentiation of acute myeloid leukemia (AML) cells into macrophages and proliferation arrest .
Cat. No.: HY-145121R
CAS No.: 2871872-79-4
Research Areas:
DS96432529 (Standard) is the analytical standard of DS96432529 (HY-145121). This product is intended for research and analytical applications. DS96432529 is an orally active CDK8 inhibitor with an IC50 of 33 nM. DS96432529 enhances ALPase activity, with an EC200 of 63 nM. DS96432529 inhibits TNF-α-induced activation of the RLR signaling pathway, activates mitophagy, accelerates mineralized nodule formation, and suppresses the proliferation of periodontal ligament stem cells. DS96432529 promotes bone formation, alleviates ligation-induced alveolar bone loss, and increases bone mineral density in ovariectomized animal models. DS96432529 can be used in studies related to periodontitis and osteoporosis .
Cat. No.: HY-160121
CAS No.: 76319-15-8
Synonyms: Patrinoside aglycone
Cat. No.: HY-169327
CAS No.: 2415160-21-1
MD-265 is a PROTAC degrader targeting MDM2, which activates p53 in cancer cells carrying wild-type p53. MD-265 induces MDM2 degradation by recruiting the CRL4-CRBN ligase complex via the ubiquitination and proteasomal degradation pathway. MD-265 upregulates p53 target genes, induces apoptosis, reduces Mcl-1 levels, increases caspase-3 cleavage, and inhibits colony formation of wild-type p53 leukemia stem cells. MD-265 can be used in research related to leukemia and acute myeloid leukemia .
Cat. No.: HY-N0754
CAS No.: 877822-40-7
Cat. No.: HY-103701AR
CAS No.: 113170-55-1
Synonyms: 2-Phospho-L-ascorbic acid magnesium (Standard); LAA2P magnesium (Standard)
Cat. No.: HY-107413R
CAS No.: 146670-40-8
Synonyms: BMS-649 (Standard)
Research Areas:
SR11237 (Standard) is the analytical standard of SR11237 (HY-107413). This product is intended for research and analytical applications. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .
Cat. No.: HY-107837R
CAS No.: 66170-10-3
Synonyms: 2-Phospho-L-ascorbic acid trisodium (Standard)
Cat. No.: HY-110280R
CAS No.: 1776116-74-5
Target:
Research Areas:
MC1742 (Standard) is the analytical standard of MC1742 (HY-110280). This product is intended for research and analytical applications. MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC .
Cat. No.: HY-116705G
CAS No.: 70763-62-1
Synonyms: 2-Fluorofucose (GMP)
Cat. No.: HY-132974
CAS No.: 165179-35-1
Synonyms: NSC-686288
Target:
Aryl Hydrocarbon Receptor Reactive Oxygen Species (ROS) DNA Alkylator/Crosslinker DNA/RNA Synthesis Caspase Apoptosis HIF/HIF Prolyl-Hydroxylase
Research Areas:
Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer .
Cat. No.: HY-15001G
CAS No.: 1227633-49-9
Synonyms: SR1 (GMP)
Cat. No.: HY-160850
CAS No.: 384835-48-7
Target:
Research Areas:
C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) is a specific type of long-chain molecule found in murine skin . C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) promotes migration of both mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells at concentrations between 0.5-5 µM. C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt)’s levels are higher in CFPAC-1 pancreatic ductal adenocarcinoma cells than in pancreatic cancer stem cells .
Cat. No.: HY-186001
CAS No.: 2922732-38-3
Synonyms: RM-044
RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1 + state to the Lgr5 + stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma .
Cat. No.: HY-187170
CAS No.: 3038211-56-9
Research Areas:
BM-51 is a selective inhibitor of CYP4Z1, with a human IC50 value of 91.7 nM. BM-51 binds to amino acid residues of CYP4Z1, thereby inhibiting its enzymatic activity. BM-51 downregulates the protein expression of stem cell markers (ALDH1A1, SOX2, OCT3/4 and KLF4) in cancer cells, inhibits cancer cell migration and invasion, and exhibits low toxicity to normal cells/tissues. BM-51 suppresses tumor initiation capacity and enhances the chemotherapeutic efficacy of Doxorubicin (HY-15142A). BM-51 can be used in breast cancer-related research .
Cat. No.: HY-N21980
CAS No.: 65563-75-9
Target:
Cat. No.: HY-N9790
CAS No.: 79907-44-1
Target:
Cat. No.: HY-P4866
CAS No.: 1361235-89-3
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
