2. PROTAC Apoptosis
  3. PROTACs MDM-2/p53
  4. MD-265

MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754); Black: linker; Blue: Lenalidomide (HY-A0003).

For research use only. We do not sell to patients.

MD-265

MD-265 Chemical Structure

CAS No. : 2415160-21-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

MD-265 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754); Black: linker; Blue: Lenalidomide (HY-A0003)[1].

Molecular Weight

921.88

Formula

C50H51Cl2FN6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O)N7CCC(C#CC8=C(C(C9=O)=CC=C8)CN9C(C(N%10)=O)CCC%10=O)CC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (108.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0847 mL 5.4237 mL 10.8474 mL
5 mM 0.2169 mL 1.0847 mL 2.1695 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0847 mL 5.4237 mL 10.8474 mL 27.1185 mL
5 mM 0.2169 mL 1.0847 mL 2.1695 mL 5.4237 mL
10 mM 0.1085 mL 0.5424 mL 1.0847 mL 2.7118 mL
15 mM 0.0723 mL 0.3616 mL 0.7232 mL 1.8079 mL
20 mM 0.0542 mL 0.2712 mL 0.5424 mL 1.3559 mL
25 mM 0.0434 mL 0.2169 mL 0.4339 mL 1.0847 mL
30 mM 0.0362 mL 0.1808 mL 0.3616 mL 0.9039 mL
40 mM 0.0271 mL 0.1356 mL 0.2712 mL 0.6780 mL
50 mM 0.0217 mL 0.1085 mL 0.2169 mL 0.5424 mL
60 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4520 mL
80 mM 0.0136 mL 0.0678 mL 0.1356 mL 0.3390 mL
100 mM 0.0108 mL 0.0542 mL 0.1085 mL 0.2712 mL
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MD-265 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD-2652415160-21-1MD265MD 265PROTACsMDM-2/p53PROTACMDM2p53tumorleukemiaInhibitorinhibitorinhibit

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