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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
309 Results for "
BCL-2/BAX
" in MedChemExpress (MCE) Product Catalog:
Products (309)
309 Results for "BCL-2/BAX" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N0307
CAS No.: 114902-16-8
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Triterpenes Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Extract
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Cat. No.: HY-W250111
CAS No.: 83512-85-0
(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research .
Cat. No.: HY-101997
CAS No.: 455311-98-5
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BEPP hydrochloride is a double-stranded RNA-dependent protein kinase (PKR) modulator. BEPP hydrochloride enhances the phosphorylation levels of PKR and eIF2α, activates caspase-3, upregulates the pro-apoptotic protein BAX, and downregulates the anti-apoptotic protein Bcl-2. BEPP hydrochloride inhibits vaccinia virus replication and exhibits selective cytotoxicity in cells expressing PKR. BEPP hydrochloride can be used in research related to cancer and viral infections .
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Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain .
Cat. No.: HY-P1380A
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Cat. No.: HY-N1157
CAS No.: 29376-68-9
Synonyms: Apigenin-5-methyl ether
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Cat. No.: HY-N1930
CAS No.: 23811-08-7
Synonyms: Hinesol
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Cat. No.: HY-N0867
CAS No.: 54706-70-6
Category:
Terpenoids Other Diseases Leptochloa chinensis (Linn.) Nees Diterpenoids Plants Gramineae Extract Disease Research Fields
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Synonyms: N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride
Research Areas:
Desethylamiodarone hydrochloride (N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone hydrochloride downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone hydrochloride can be used in cervical cancer-related research .
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BAX-IN-1 is a potential, selective inhibitor of Bcl-2-associated X protein (BAX).
Cat. No.: HY-175397
Synonyms: DFHBI-thalidomide
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Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research .
Cat. No.: HY-N10144
CAS No.: 157414-04-5
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Shinpterocarpin is a flavonoid compound. Shinpterocarpin can be isolated from the air-dried roots of Glycyrrhiza glabra L. and Xuanshen Decoction. Shinpterocarpin binds to the targets PI3K, AKT, Nrf2, Bcl-2, Bax, CAT and SOD. Shinpterocarpin enhances immunity and exerts antioxidant effects by reducing the production of ROS .
Cat. No.: HY-161659
CAS No.: 3049296-75-2
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Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .
Cat. No.: HY-115974
CAS No.: 3052544-28-9
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GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis, with anticancer activity .
Cat. No.: HY-172394
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ZSNI-21 is a ADAM17/HDAC2 inhibitor with ADAM17 IC50 0.939 μM and HDAC2 IC50 0.844 μM. ZSNI-21 regulates the expression of apoptosis-related proteins (Bax, Bcl-2) and Cyclin D1, and induces apoptosis.. ZSNI-21 can be used for the research of hepatocellular carcinoma, breast cancer, and non-small cell lung cancer .
Cat. No.: HY-P5325A
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Cat. No.: HY-P5325
CAS No.: 505070-05-3
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Cat. No.: HY-136778
CAS No.: 137881-27-7
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INH2BP is a poly(ADP-ribose) polymerase (PARP) inhibitor with antioxidant and anti-apoptotic activities. INH2BP reduces the production of intracellular reactive oxygen species (ROS), modulates the expression of apoptosis-related proteins such as Bax, Bcl-2 and cleaved caspase-3 and enhances cell survival through the activation of the ERK1/2 and p38 MAPK signaling pathways. INH2BP is promising for research of cardiovascular diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
