602 Results for "

L-cell fibroblasts

" in MedChemExpress (MCE) Product Catalog:
Products (602)

602 Results for "L-cell fibroblasts" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-101493
CAS No.: 704869-38-5
Purity:  98.80%
Target:  

FGFR

Research Areas:  

Neurological Disease

SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity.
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2
2 Cited Publications
Cat. No.: HY-113447
CAS No.: 72-23-1
Purity:  95.24%
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .
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2
2 Cited Publications
Cat. No.: HY-100684
CAS No.: 1448440-52-5
Purity:  99.51%
Research Areas:  

Cancer

UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM .
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2
2 Cited Publications
Cat. No.: HY-114311
CAS No.: 2308497-58-5
Purity:  98.26%
Research Areas:  

Cancer

FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM and 3.2 nM, respectively. Antitumor activity .
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2
2 Cited Publications
Cat. No.: HY-15039
CAS No.: 464930-42-5
Purity:  99.51%
SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.
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2
2 Cited Publications
Cat. No.: HY-A0087
CAS No.: 6197-30-4
Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes .
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2
2 Cited Publications
Cat. No.: HY-N0671
CAS No.: 155-58-8
Synonyms: Rhaponiticin
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .
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2
2 Cited Publications
Cat. No.: HY-N6985
CAS No.: 27548-93-2
Baccatin III is an orally available, selective inhibitor of the TGF-β1 signaling pathway and myeloid-derived suppressor cell (MDSC) activation. Baccatin III targets the AKT/STAT6 and Smad2/3 pathways, blocking TGF-β1-induced fibroblast differentiation and MDSC-mediated immunosuppression. Baccatin III exerts anti-inflammatory and anti-fibrotic effects by inhibiting macrophage activation and extracellular matrix deposition, and shows potential in the treatment of pulmonary fibrosis and cancer in terms of regulating the tumor immune microenvironment .
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2
2 Cited Publications
Cat. No.: HY-P990859

Research Areas:  

Cancer

Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derived Growth Factor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic .
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2
2 Cited Publications
Cat. No.: HY-N0353
CAS No.: 13657-68-6
Synonyms: (+)-Curdione
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC50 = 1.1 μM) and cyclooxygenase 2 expression .
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1
1 Cited Publications
Cat. No.: HY-12656
CAS No.: 171927-40-5
Purity:  98.70%
Target:  

Ras

Research Areas:  

Cancer

SCH 51344 inhibits Ras induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts .
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1
1 Cited Publications
Cat. No.: HY-116392H
CAS No.: 80943-40-4
Purity:  99.67%
Research Areas:  

Others

D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .
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1
1 Cited Publications
Cat. No.: HY-N6876
CAS No.: 59472-23-0
Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts .
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1
1 Cited Publications
Cat. No.: HY-P99269
CAS No.: 216669-97-5
Synonyms: BIBH 1; Anti-Human FAP Recombinant Antibody

Target:  

FAP

Research Areas:  

Cancer

Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC) .
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1
1 Cited Publications
Cat. No.: HY-P700279
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; Keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-47979
CAS No.: 2471983-20-5
Target:  

FAP

Research Areas:  

Cancer

FAP-IN-2 is an isonitrile-containing fibroblast activation protein (FAP) inhibitor. FAP-IN-2 can be labeled with technetium-99m ( 99mTc) for targeted tumor SPECT imaging .
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1
1 Cited Publications
Cat. No.: HY-P7048
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; Keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P7342AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By fibroblasts Of Urinary Bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; Keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-W404002
CAS No.: 2505339-54-6
Research Areas:  

Metabolic Disease

BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2
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1
1 Cited Publications
Cat. No.: HY-108999A
CAS No.: 96389-68-3
Purity:  99.51%
Synonyms: BWA770U
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .
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