1885 Results for "

Reactive

" in MedChemExpress (MCE) Product Catalog:
Products (1885)

1885 Results for "Reactive" in MCE Product Catalog:

12
Ginsenoside Rk1
Ginsenoside Rk1
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12 Cited Publications
製品番号: HY-N2515
CAS 番号: 494753-69-4
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae

Target:  

NF-κB PI3K JAK Apoptosis

Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .
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10
Glutathione oxidized
Glutathione oxidized
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10 Cited Publications
製品番号: HY-D0844
CAS 番号: 27025-41-8
別名: L-Glutathione oxidized; GSSG; Oxiglutatione
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Reactive Oxygen Species (ROS)

Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
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10
Isobavachalcone
Isobavachalcone
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10 Cited Publications
製品番号: HY-13065
CAS 番号: 20784-50-3
純度:  99.01%
別名: Corylifolinin; Isobacachalcone
Category:  

Plants Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .
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9
Imeglimin hydrochloride
Imeglimin hydrochloride
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9 Cited Publications
製品番号: HY-14771A
CAS 番号: 775351-61-6
純度:  99.98%
別名: EMD 387008 hydrochloride
Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS)

研究分野:  

Metabolic Disease

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .
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9
Sulfo-NHS-LC-Biotin sodium
Sulfo-NHS-LC-Biotin sodium
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9 Cited Publications
製品番号: HY-D0799
CAS 番号: 191671-46-2
Target:  

Fluorescent Dye

研究分野:  

Others

Sulfo-NHS-LC-Biotin sodium is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.
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9
Imeglimin
Imeglimin
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9 Cited Publications
製品番号: HY-14771
CAS 番号: 775351-65-0
別名: EMD 387008
Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS)

研究分野:  

Metabolic Disease

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .
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9
Danshensu
Danshensu
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9 Cited Publications
製品番号: HY-N1913
CAS 番号: 76822-21-4
別名: Dan shen suan A; Salvianic acid A
Category:  

Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .
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9
Danshensu sodium
Danshensu sodium
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9 Cited Publications
製品番号: HY-N1913A
CAS 番号: 81075-52-7
別名: Dan shen suan A sodium; Salvianic acid A sodium
Category:  

Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .
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9
Guanosine triphosphate trisodium salt hydrate
Guanosine triphosphate trisodium salt hydrate
0 Images
9 Cited Publications
製品番号: HY-12695B
CAS 番号: 207300-85-4
純度:  ≥95.0%
別名: GTP trisodium salt hydrate
Category:  

天然物 Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) trisodium salt hydrate is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium salt hydrate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium salt hydrate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium salt hydrate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium salt hydrate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .
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9
Guanosine triphosphate disodium
Guanosine triphosphate disodium
0 Images
9 Cited Publications
製品番号: HY-W010737
CAS 番号: 56001-37-7
別名: GTP disodium
Category:  

天然物 Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) disodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate disodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate disodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate disodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate disodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .
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8
Sulfo-NHS-SS-Biotin sodium
Sulfo-NHS-SS-Biotin sodium
0 Images
8 Cited Publications
製品番号: HY-111496
CAS 番号: 325143-98-4
純度:  ≥97.0%
Sulfo-NHS-SS-biotin sodium is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin sodium can be used for the labeling and purifying of cell-surface protein .
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8
Apigenin 7-glucoside
Apigenin 7-glucoside
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8 Cited Publications
製品番号: HY-N0578
CAS 番号: 578-74-5
別名: Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin
Category:  

Flavonoids Flavones Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS)

Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .
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8
TMB
TMB
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8 Cited Publications
製品番号: HY-15930
CAS 番号: 54827-17-7
別名: BM blue; Sure Blue TMB
TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
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8
TMB dihydrochloride
TMB dihydrochloride
0 Images
8 Cited Publications
製品番号: HY-15930A
CAS 番号: 64285-73-0
別名: BM blue dihydrochloride; Sure Blue TMB dihydrochloride
TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
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8
TMB dihydrochloride x.hydrate
TMB dihydrochloride x.hydrate
0 Images
8 Cited Publications
製品番号: HY-15930B
CAS 番号: 207738-08-7
別名: Sure Blue TMB dihydrochloride x.hydrate
TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
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8
TMB monosulfate
TMB monosulfate
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8 Cited Publications
製品番号: HY-15930C
CAS 番号: 54827-18-8
別名: BM blue monosulfate; Sure Blue TMB monosulfate
TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
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8
DIF-3
DIF-3
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8 Cited Publications
製品番号: HY-145669
CAS 番号: 113411-17-9
純度:  99.84%
Target:  

Wnt CDK GSK-3

研究分野:  

Infection Cancer

DIF-3 is an orally active anticancer agent. DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in cells. DIF-3 induces reactive oxygen species (ROS) and autophagy. DIF suppresses the growth of Trypanosoma. cruzi in HT1080 cells. DIF-3 exerts antitumor effects both in vitro and in vivo .
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7
IR-780
IR-780
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7 Cited Publications
製品番号: HY-D1063
CAS 番号: 207399-07-3
IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .
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7
Hinokiflavone
Hinokiflavone
0 Images
7 Cited Publications
製品番号: HY-N2360
CAS 番号: 19202-36-9
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Biflavones Cancer

Target:  

E1/E2/E3 Enzyme Apoptosis MMP ClpP

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .
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7
(2Z)-2-Methyl-2-butenedioic acid
(2Z)-2-Methyl-2-butenedioic acid
0 Images
7 Cited Publications
製品番号: HY-113298
CAS 番号: 498-23-7
純度:  98.73%
別名: Methylmaleic acid; Citraconate
Category:  

Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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