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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
156 Results for "
lateral
" in MedChemExpress (MCE) Product Catalog:
Products (156)
156 Results for "lateral" in MCE Product Catalog:
Cat. No.: HY-153399
CAS No.: 2415715-84-1
Synonyms: ABBV-CLS-7262
Research Areas:
Fosigotifator (ABBV-CLS-7262) is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator is an integrated stress response inhibitor (ISRI). Fosigotifator can be used for amyotrophic lateral sclerosis research .
Cat. No.: HY-170409
CAS No.: 1195795-81-3
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BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable .
Cat. No.: HY-N11021
CAS No.: 65646-26-6
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Cat. No.: HY-181846
CAS No.: 1065567-62-5
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nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis .
Cat. No.: HY-P5741
CAS No.: 877120-59-7
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Cat. No.: HY-18573
CAS No.: 301176-96-5
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Naxillin is a non-auxin-like molecule, which can promote the lateral root branching in the basal meristem of the root, through the conversion of the auxin precursor indole-3-butyric acid (IBA) to the active auxin indole-3-acetic acid (IAA) .
Cat. No.: HY-114753
CAS No.: 163000-63-3
Synonyms: CR-2249; XY-2401
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Neboglamine (CR-2249; XY-2401) is a modulator for N-methyl-D-aspartate (NMDA) receptor. Neboglamine increases the levels of fos-like immunoreactivity (FLI)-positive cells in the prefrontal cortex, nucleus accumbens, and lateral septal nucleus in rat models, .restores NMDA (HY-17551) -mediated neurotransmitter release, and inhibits phencyclidine-induced hyperlocomotion .
Cat. No.: HY-B1833R
CAS No.: 56287-74-2
Synonyms: HQ-495 (Standard)
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Afloqualone (Standard) is the analytical standard of Afloqualone. This product is intended for research and analytical applications. Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome .
Cat. No.: HY-114898
CAS No.: 1826026-00-9
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ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke .
Cat. No.: HY-172152
CAS No.: 3024617-59-9
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MP-010 is a FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. MP-010 promotes functional improvement in SOD1 G93A amyotrophic lateral sclerosis (ALS) mice, as evidenced by improved motor coordination, increased integrity of neuromuscular junctions, and significantly enhanced survival of spinal motor neurons. MP-010 can be used for research in the field of neurological diseases .
Cat. No.: HY-173366
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dGEM3 is a selective GEMIN3 Molecular glue degrader with a DC50 of 680 nM. dGEM3 recruits GEMIN3 to the VHL E3 ligase, and mediates the targeted ubiquitination and degradation of GEMIN3 via the ubiquitin-proteasome system. dGEM3 induces extensive transcriptomic changes, including upregulation of ER stress response genes and downregulation of mRNA splicing genes. dGEM3 can be used in research related to amyotrophic lateral sclerosis, spinal muscular atrophy and neuromuscular dysfunction .
Cat. No.: HY-178358
CAS No.: 2352652-76-5
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JAX-44 is a potent root architecture modulator. JAX-44 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-44 is the metabolic precursor of JAX-77 (HY-178359) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-44 can be used for auxin biology and root development research .
Cat. No.: HY-146527
CAS No.: 2574593-54-5
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c-ABL-IN-2 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-2 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2020260871A1, compound 25) . c-ABL-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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DNA, d([2'-O-(2-methoxyethyl)](m5rU-sp-rG-rG-rA-m5rU-m5rU)-m5C-sp-T-sp-G-sp-T-sp-A-sp-m5C-sp-T-sp-T-sp-T-sp-T-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA)
Cat. No.: HY-177645
CAS No.: 2757908-12-4
Cat. No.: HY-P10627
CAS No.: 2760733-01-3
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Cat. No.: HY-120570
CAS No.: 1356959-71-1
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WN1316 is an oral active antioxidant agent. WN1316 shows neuroprotectant activity and can be used for study of amyotrophic lateral sclerosis .
Cat. No.: HY-N1974R
CAS No.: 80665-72-1
Synonyms: 15α-Hydroxyneoline (Standard)
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Cat. No.: HY-113726
CAS No.: 102771-12-0
Synonyms: GYKI52322; EGIS-6775
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Nerisopam is an orally active gamma-aminobutyric acid (GABA) receptor agonist. Nerisopam is an anxiolytic and antipsychotic homophthalazine. Nerisopam induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat .
Cat. No.: HY-N15781
CAS No.: 1882060-21-0
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Trans-FAAzo-4 is a photo-switchable fatty acid analogue used in photo-pharmacology. Trans-FAAzo-4 is able to alter membrane lateral pressure and thus control opening and closing of mechanosensitive ion channels .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
