Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
270 Results for "
ECL4 loop
" in MedChemExpress (MCE) Product Catalog:
Products (270)
270 Results for "ECL4 loop" in MCE Product Catalog:
Cat. No.: HY-174801
CAS No.: 3117797-30-2
Target:
Research Areas:
XL-3156 is a cGAS inhibitor. XL-3156 occupies both allosteric and orthosteric sites simultaneously, and inhibits the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of diseases such as autoimmune diseases and inflammation .
Target:
Research Areas:
Triosephosphate isomerase (TPI) is a biocatalyst that interconverts dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. Triosephosphate isomerase utilises Glu167 as catalytic base, mediates proton shuttling, and stabilises a cis-enediolate intermediate via loop-6 and loop-7 closure to shield its catalytic site. Triosephosphate isomerase can be used for the research of triosephosphate isomerase deficiency .
Synonyms: BAY-g 2821; Edrul
Target:
Research Areas:
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease .
Cat. No.: HY-P99102
CAS No.: 2417213-75-1
Synonyms: 10-1074
Cat. No.: HY-130487
CAS No.: 304880-74-8
miR-21-IN-2 is a high-affinity miR-21 inhibitor. miR-21-IN-2 binds to the apical loop region of the pre-miR-21 hairpin, inhibits Dicer-mediated processing, and thereby blocks the biosynthesis of mature miR-21. miR-21-IN-2 can be used for the research of microRNA-related diseases .
Cat. No.: HY-P1594A
Target:
Research Areas:
Cat. No.: HY-W317853
CAS No.: 521972-99-6
Target:
Research Areas:
Protonstatin-1 is a selective plasma membrane (PM) H +-ATPase inhibitor (IC50 of 3.9 μM) that inhibits auxin transport. Protonstatin-1 interacts with the PM H +-ATPase central loop and may thus impede the functions of the N- and/or P-domain to inhibit the pump activity .
Target:
Research Areas:
PDP-Pfp is a reducible ADC Linker used as an active molecule targeting the extracellular loop 1 (ECL1) of TM4SF1 .
Cat. No.: HY-B0247S
CAS No.: 1189375-06-1
Synonyms: Torasemide-d7
Cat. No.: HY-134193
CAS No.: 396721-89-4
Target:
Research Areas:
KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals .
Cat. No.: HY-163035
CAS No.: 1206480-93-4
Target:
Research Areas:
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) .
Cat. No.: HY-B0247R
CAS No.: 56211-40-6
Synonyms: Torasemide (Standard)
Target:
Research Areas:
Torsemide (Standard) is the analytical standard of Torsemide. This product is intended for research and analytical applications. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .
Cat. No.: HY-P1508
CAS No.: 116229-36-8
Synonyms: Bactenecin, bovine
Category:
Infection Animals Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
Cat. No.: HY-148200
CAS No.: 1016263-75-4
Target:
Research Areas:
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM .
Cat. No.: HY-P1508A
Synonyms: Bactenecin, bovine TFA
Cat. No.: HY-P2612A
Target:
Cat. No.: HY-P5229A
Target:
Research Areas:
Cat. No.: HY-175419
Synonyms: trans bis-Isatoic anhydride
Target:
Research Areas:
TBIA (trans bis-isatoic anhydride) is a covalent RNA crosslinker. TBIA selectively induces RNA tertiary interactions (e.g., multi-helix junctions, loop-helix packing). TBIA is promising for research of RNA higher-order structure and disease-associated RNAs (e.g., KRAS-mutant RNAs) .
Cat. No.: HY-172400
CAS No.: 3046390-69-3
Target:
Research Areas:
FXIa-IN-16 is an orally active selective FXIa inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exerts highly selective competitive inhibition on endogenous FXIa, blocks the thrombin amplification loop to inhibit thrombosis, while preserving exogenous physiological hemostatic function. FXIa-IN-16 can be used in thrombosis-related research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
