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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
137 Results for "
antileukemic
" in MedChemExpress (MCE) Product Catalog:
Products (137)
137 Results for "antileukemic" in MCE Product Catalog:
Category:
Artemisia douglasiana Plants Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
Synonyms: Mercaptopurine-13C2,15N; 6-MP-13C2,15N
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc) .
Cat. No.: HY-153495
CAS No.: 202484-91-1
Synonyms: BP1001
Research Areas:
Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia .
Synonyms: TP-0184 hydrochloride
Research Areas:
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity .
Cat. No.: HY-13677AR
CAS No.: 6112-76-1
Synonyms: Mercaptopurine hydrate (Standard); 6-MP hydrate (Standard)
Research Areas:
6-Mercaptopurine hydrate (Standard) is the analytical standard of 6-Mercaptopurine hydrate. This product is intended for research and analytical applications. 6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
Cat. No.: HY-120997
CAS No.: 114784-59-7
Synonyms: Berbamine p-nitrobenzoate
Target:
Research Areas:
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia .
Cat. No.: HY-P99027
CAS No.: 2137049-37-5
Synonyms: LAG525; IMP701; Hu5A8
Cat. No.: HY-133900
CAS No.: 36804-95-2
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .
Cat. No.: HY-111008A
CAS No.: 95933-75-8
Synonyms: VF-233 hydrochloride
Target:
Research Areas:
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM .
Cat. No.: HY-13677S
CAS No.: 82677-93-8
Synonyms: Mercaptopurine-d2; 6-MP-d2
Cat. No.: HY-111275
CAS No.: 857064-42-7
WP-1034 is a JAK-STAT inhibitor with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). WP-1034 blocks activation of Stat 3 and 5. WP-1034 induces cell cycle arrest and triggers apoptosis. WP-1034 can be used for AML research .
AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABL WT, BCR-ABL T315, BCR-ABL E255K, BCR-ABL F3171, BCR-ABL H396P and BCR-ABL Q252H with IC50s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line .
Cat. No.: HY-U00095R
CAS No.: 96892-57-8
Synonyms: NCI 329680 (Standard); ZINC01574758 (Standard)
Research Areas:
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC50 of 0.91 μg/mL in a panel of different tumors.
Cat. No.: HY-17381R
CAS No.: 57852-57-0
Synonyms: 4-Demethoxydaunorubicin hydrochloride (Standard)
Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
Cat. No.: HY-N17612
CAS No.: 366477-44-3
Target:
Cat. No.: HY-115754
CAS No.: 53330-02-2
Synonyms: PEITC-Cys
Target:
Research Areas:
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells . S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .
Category:
Cat. No.: HY-160787
CAS No.: 2193085-94-6
NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity .
Cat. No.: HY-107338
CAS No.: 51287-57-1
Synonyms: Vratizolin; Wratizolin
Target:
Research Areas:
Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
