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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
735 Results for "
beta2
" in MedChemExpress (MCE) Product Catalog:
Products (735)
735 Results for "beta2" in MCE Product Catalog:
Category:
Cat. No.: HY-B0573S1
CAS No.: 344298-99-3
Cat. No.: HY-W192276
CAS No.: 20862-11-7
Synonyms: N-Desisopropylpropranolol
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Endocrinology Cancer
(±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy [2] .
Cat. No.: HY-B1421
CAS No.: 90274-24-1
Synonyms: LY031537
Research Areas:
Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs [2] .
Cat. No.: HY-10232R
CAS No.: 64603-91-4
Synonyms: Gaboxadol (Standard)
Target:
Research Areas:
THIP (Gaboxadol) Standard is the analytical standard of THIP (HY-10232). This product is intended for research and analytical applications. THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors [2] .
Cat. No.: HY-10232S
CAS No.: 2748778-97-2
Synonyms: Gaboxadol-d4
Research Areas:
THIP-d4 (Gaboxadol-d4) is the deuterated-labeled THIP (HY-10232). THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors [2] .
Cat. No.: HY-10233R
CAS No.: 85118-33-8
Synonyms: Lu 02-030 hydrochloride (Standard); THIP hydrochloride (Standard)
Target:
Research Areas:
Gaboxadol (hydrochloride) (Standard) is the analytical standard of Gaboxadol (hydrochloride). This product is intended for research and analytical applications. Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM). Gaboxadol hydrochloride is a non-opioid agent [2].
Cat. No.: HY-113781
CAS No.: 97825-25-7
Synonyms: LY031537 free base
Research Areas:
Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs [2] .
Cat. No.: HY-171889
CAS No.: 1644498-53-2
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
BI-9774 is a potent, selective, and orally active AMPK activator, with EC50 values of 20.0 nM and 63.1 nM against human AMPK α1β1γ1 and AMPK α1β2γ1, respectively. BI-9774 binds to the allosteric drug and metabolite (ADaM) site and induces ACC Ser79 phosphorylation in HepG2 cells, with an EC50 of 83.2 nM. BI-9774 can be used in studies related to AMPK signaling, multiple sclerosis, and non-alcoholic fatty liver disease [2] .
Cat. No.: HY-P701730
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38beta; P38beta2; Mitogen-Activated Protein Kinase P38 beta; MAPK 11; MAP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W097625R
CAS No.: 26964-24-9
Cat. No.: HY-P701731
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38beta; P38beta2; Mitogen-Activated Protein Kinase P38 beta; MAPK 11; MAP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705668
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38beta; P38beta2; Mitogen-Activated Protein Kinase P38 beta; MAPK 11; MAP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706079
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38beta; P38beta2; Mitogen-Activated Protein Kinase P38 beta; MAPK 11; MAP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-100672BR
CAS No.: 1932675-95-0
Target:
Research Areas:
(2R)-SR59230A (Standard) is the analytical standard of (2R)-SR59230A (HY-100672B). This product is intended for research and analytical applications. (2R)-SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively [2].
Cat. No.: HY-10087R
CAS No.: 923564-51-6
Synonyms: ABT-263 (Standard)
Navitoclax (Standard) (ABT-263 (Standard)) is the analytical standard of Navitoclax (HY-10087). This product is intended for research and analytical applications. Navitoclax (ABT-263 ) is an orally active BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with a Ki value of <1 nM for each target. Navitoclax triggers endogenous Apoptosis and downregulates the expression of Survivin and TGFβ2. Navitoclax alleviates fibrosis and induces thrombocytopenia. Navitoclax exhibits anticancer activity against a variety of tumors and enhances the efficacy of chemotherapy and radiotherapy. Navitoclax can be used in the research of acute lymphoblastic leukemia, ovarian cancer, and fibrotic diseases [2] .
Cat. No.: HY-105670R
CAS No.: 478149-53-0
Target:
Research Areas:
PHA-543613 (Standard) is the analytical standard of PHA-543613 (HY-105670). This product is intended for research and analytical applications. PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors . PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research [2].
Synonyms: (1S,5R)-CP-601927
Target:
Research Areas:
CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21 nM; EC50=~ 3 μM). CP-601932 has the same high-binding affinity at α4β2 nAChR (Ki=21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS .
Cat. No.: HY-175286
Research Areas:
α4β1 antagonist-1 (Compound 4) is a highly selective α4β1 integrin antagonist (IC50=15 nM). α4β1 antagonist-1 inhibits integrin-mediated cell adhesion and ERK1/2 signaling activation. α4β1 antagonist-1 also exhibits partial agonism toward αMβ2 integrin (EC50=23 nM). α4β1 antagonist-1 is promising for research of chronic inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancers .
Cat. No.: HY-P99292
CAS No.: 326859-36-3
Synonyms: HuZAF; Anti-Human IFNG Recombinant Antibody
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
