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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
differential pulse voltammetry
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "differential pulse voltammetry" in MCE Product Catalog:
Cat. No.: HY-N21624
CAS No.: 199925-44-5
Target:
Cat. No.: HY-110082R
CAS No.: 130-89-2
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Quinine hydrochloride (Standard) is the analytical standard of Quinine (hydrochloride) (HY-110082). This product is intended for research and analytical applications. Quinine (hydrochloride) is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine (hydrochloride) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
Cat. No.: HY-189512
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Simmon's Citrate Agar is a synthetic differential medium that uses sodium citrate as the sole carbon source. Simmon's Citrate Agar can determine the ability of bacteria to utilize citrate as a carbon source. Bacterial metabolism of citrate produces bicarbonate, which causes bromothymol blue to change from blue to deep blue. Simmon's Citrate Agar can be used for bacterial identification and isolation-related research .
Cat. No.: HY-106391
CAS No.: 33765-68-3
Synonyms: TSAA-291
Target:
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Oxendolone (TSAA-291) is a steroidal antiandrogen with partial agonist properties, exhibiting a Ki value of 1.4 nM for the androgen receptor. Oxendolone exerts tissue-specific androgen receptor activity, induces unique androgen receptor conformational changes, and drives differential cofactor recruitment. Oxendolone is recruited to the androgen receptor in a PIAS1-dependent manner. Oxendolone increases levator ani muscle weight in castrated mice. Oxendolone can be used for research on benign prostatic hyperplasia .
Cat. No.: HY-187015
CAS No.: 74141-74-5
Synonyms: NSC 314055
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SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC50 of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research .
Cat. No.: HY-183279
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FXR antagonist 4 (Compound 4l) is an orally active, selective FXR antagonist with an IC50 of 0.70 μM. FXR antagonist 4 binds to FXR, differentially regulates bile acid and lipid transporter genes, and exerts no effect on gluconeogenesis-related genes. FXR modulator 1 activates the AMPK signaling pathway to inhibit fatty acid synthesis. FXR modulator 1 alleviates hepatic steatosis, ballooning degeneration and fibrosis, and improves dyslipidemia. FXR modulator 1 can be used for research on metabolic dysfunction-associated steatohepatitis .
Cat. No.: HY-P70076
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NBL1; Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1; NBL1, DAN Family BMP Antagonist; differential Screening-Selected Gene Aberrant In Neuroblastoma; Neuroblastoma Suppressor Of Tumorigenicity 1; Neuroblastoma 1, DAN Family BMP Antagonis
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74736
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NBL1; Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1; NBL1, DAN Family BMP Antagonist; differential Screening-Selected Gene Aberrant In Neuroblastoma; Neuroblastoma Suppressor Of Tumorigenicity 1; Neuroblastoma 1, DAN Family BMP Antagonis
Species:
Human
Source:
HEK293
Cat. No.: HY-P74737
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NBL1; Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1; NBL1, DAN Family BMP Antagonist; differential Screening-Selected Gene Aberrant In Neuroblastoma; Neuroblastoma Suppressor Of Tumorigenicity 1; Neuroblastoma 1, DAN Family BMP Antagonis
Species:
Human
Source:
HEK293
Cat. No.: HY-115894
CAS No.: 423732-11-0
DapL-IN-1 is an inhibitor of L,L-diaminoheptanoic acid aminotransferase (DapL) with the characteristics of inhibiting DapL activity in bacteria and plants. DapL-IN-1 can be used to design and discover new biocides such as antibiotics, herbicides or algaecides with the potential to be non-toxic to animals. DapL-IN-1 shows differential sensitivity in inhibiting different DapL homologues, which can provide important information for further drug development. DapL-IN-1 may affect its biological activity by affecting the interaction with residues adjacent to the active site, which may lead to different binding modes .
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Sodium bromide (NSC 77384; Sanibrom 40) is a GABA-ergic system modulator that crosses the blood-brain barrier, and it effectively reduces and blocks epileptiform discharges. Sodium bromide exerts significant anticonvulsant effects by enhancing GABA-ergic inhibitory functions, such as increasing the amplitude of inhibitory postsynaptic currents and paired-pulse inhibition. Sodium bromide specifically enhances stimulation-induced extracellular alkalosis without affecting baseline pH or subsequent acidosis processes. Sodium bromide exhibits species-specific pharmacokinetic characteristics, competes with chloride ions for renal tubular reabsorption sites, and serves as a marker for extracellular fluid volume. Sodium bromide can be used in the research of epilepsy and related neurological diseases .
Cat. No.: HY-D3361
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JF639-HTL is a deep-red fluorescent dye belonging to the Janelia Fluor series and also a HaloTag ligand. JF639-HTL contains a methoxy group as the R substituent, which forms a specific covalent bond with HaloTag fusion proteins. JF639-HTL is fluorogenic, exhibiting low background fluorescence in solution and a significant fluorescence enhancement upon binding to proteins. It also possesses cell permeability and excellent photostability. JF639-HTL can be used in studies related to fluorescent labeling, localization tracking, and pulse-chase imaging of proteins in living cells .
Cat. No.: HY-DY2022
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Eosin-Nigrosin Sperm Viability Staining Solution is a differential viability staining solution used to distinguish live/dead sperm and other cells, consisting of Eosin Y (HY-D0505) and Nigrosin (HY-W250145). Eosin-Nigrosin Sperm Viability Staining Solution cannot penetrate the membrane of live cells; it stains dead cells dark pink and uses nigrosin to form a contrasting dark background. Eosin-Nigrosin Sperm Viability Staining Solution can distinguish live sperm, dead sperm and sperm with neck leakage, and can stain dead sperm or sperm affected by excessive microbial growth .
Cat. No.: HY-W026930
CAS No.: 82-05-3
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Benzanthrone is an immunotoxic, pro-inflammatory Photosensitizer. Benzanthrone upregulates iNOS, COX-2 and inflammatory cytokines; activates ERK1/2, p38, JNK, AP-1 and NF-κB; inhibits Nrf2; and induces oxidative stress and DNA damage. Upon radiation exposure, Benzanthrone generates singlet oxygen and superoxide anion radicals, induces photohemolysis and lipid peroxidation, and alters the levels of skin xenobiotic enzymes. Benzanthrone exhibits differential genotoxicity in different cell lines. Benzanthrone possesses skin tumor-initiating and promoting activities. Benzanthrone can be used in skin tumor-related studies .
Cat. No.: HY-DY2032
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Methyl Green Staining Solution (Chloroform-Extracted, 1%) is a basic dye stock solution with differential nucleic acid binding activity that distinguishes double-stranded DNA from RNA, and it can be used for assays related to nucleic acid distribution and DNA localization. Methyl Green Staining Solution (Chloroform-Extracted, 1%) functions by competitively binding to the phosphate groups of nucleic acids and stably binds to intact double-stranded DNA; RNA within the oocyte-specific ribonucleoprotein complex specifically binds to this dye, and RNase completely blocks this binding reaction. The nucleic acid recognition of Methyl Green Staining Solution (Chloroform-Extracted, 1%) depends on the size of the dye cation and the intact double-helical structure of DNA .
Cat. No.: HY-183665
CAS No.: 76778-24-0
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Research Areas:
GBR-13119 is a blood-brain barrier-permeable inhibitor of the presynaptic dopamine uptake system. GBR-13119 binds to dopamine uptake sites with high selectivity, without being affected by other neurotransmitter reuptake inhibitors. GBR-13119 exhibits a lipophilic systemic distribution profile with extremely low defluorination in rats, while it shows a differential characteristic of slow striatal washout in the brain of primates. GBR-13119 can serve as a PET tracer to achieve visualized imaging of the striatum in primates, and can reflect MPTP-induced dopaminergic neuron degeneration through reduced uptake. GBR-13119 can be widely applied to studies related to Parkinson's disease and dopaminergic neuron degeneration .
Cat. No.: HY-DY2027
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Nissl Staining Solution (Thionin Method) is a neural tissue staining solution with thionin as the core component, which stains Nissl bodies purplish blue and nuclear chromatin blue. Nissl Staining Solution (Thionin Method) relies on positively charged thionin molecules to specifically bind to the negatively charged nucleic acid components in the rough endoplasmic reticulum inside Nissl bodies, and achieves differential staining by regulating pH through a buffer system. Nissl Staining Solution (Thionin Method) has pH-dependent staining selectivity; it exhibits the highest staining specificity for neuronal Nissl bodies under pH 3.65 conditions, and can efficiently label glial processes under pH 4.6 conditions .
Cat. No.: HY-D1737
Cat. No.: HY-16658BR
CAS No.: 161401-82-7
Synonyms: Z-VAD(OH)-FMK (Standard)
Target:
Reference Standards Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)
Research Areas:
Z-VAD-FMK (Standard) is the analytical standard of Z-VAD-FMK (HY-16658B). This product is intended for research and analytical applications. Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocKing the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
