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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
168 Results for "
Platelet activating factor
" in MedChemExpress (MCE) Product Catalog:
Products (168)
168 Results for "Platelet activating factor" in MCE Product Catalog:
Cat. No.: HY-176019
연구분야:
Methylcarbamyl PAF C-8 is resistant to the degradation function of platelet-activating factor acetylhydrolase (PAF-AH). It has a half-life of more than 100 minutes in platelet-poor plasma and possesses the activity of inducing platelet aggregation. In NRK-49 cells overexpressing the PAF receptor, Methylcarbamyl PAF C-8 can induce the expression of c-myc and c-fos, and activate mitogen-activated protein kinase (MAPK). Additionally, Methylcarbamyl PAF C-8 can induce cell cycle arrest in the G1 phase. Methylcarbamyl PAF C-8 holds promise for research in the fields of cardiovascular diseases and anti-cancer therapy .
Cat. No.: HY-132190
CAS No.: 137566-83-7
Synonyms: 1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine
Hexanolamino PAF C-16 (1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine) is a Platelet-activating Factor Receptor (PAFR) Modulator with partial agonist activity. Hexanolamino PAF C-16 induces platelet aggregation and macrophage production but fails to increase [Ca2+]i in platelets, suggesting that PAF receptors may interact with PAF receptors through Ca 2+-dependent and -independent pathways. Related to platelet aggregation .
Cat. No.: HY-N10754
CAS No.: 13060-15-6
Target:
Cat. No.: HY-132210
CAS No.: 116673-45-1
rel-(2R,4R)-2,4-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane (compound 6) is a platelet-activating factor receptor (PAFR) antagonist with a Ki of 0.3 µM .
Cat. No.: HY-106837
CAS No.: 117279-73-9
Synonyms: Y 24180
Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca 2+ influx and intracellular Ca 2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice .
Cat. No.: HY-106404
CAS No.: 205054-36-0
Target:
연구분야:
RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a Ki of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis .
Cat. No.: HY-P71185
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PAFAH1B2; Platelet-activating factor Acetylhydrolase, Isoform Ib, Beta Subunit 30kDa; Platelet activating factor Acetylhydrolase 1b Catalytic Subunit 2; Platelet-activating factor Acetylhydrolase, Isoform Ib, Subunit 2 (30kDa); Platelet-activating factor
Species:
Human
Source:
E. coli
Cat. No.: HY-N17414
CAS No.: 1457972-74-5
Cat. No.: HY-118760
CAS No.: 137031-56-2
Target:
연구분야:
Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B2 production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [ 3H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin .
Target:
연구분야:
AQ 1994 hydrochloride is a benzothiophenyl aminoethyl ketone derivative and also a broad-spectrum human platelet aggregation inhibitor. AQ 1994 hydrochloride inhibits human platelet aggregation triggered by 5'-adenosine diphosphate, arachidonic acid, platelet-activating factor, thrombin or collagen. AQ 1994 hydrochloride can be used for thrombosis-related research .
Cat. No.: HY-182418
CAS No.: 138060-13-6
UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice .
Cat. No.: HY-101833R
CAS No.: 131888-54-5
연구분야:
YM-264 (Standard) is the analytical standard of YM-264 (HY-101833). This product is intended for research and analytical applications. YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.
Cat. No.: HY-116435
CAS No.: 117796-62-0
Sch-40338 is a dual antagonist of platelet-activating factor (PAF) and histamine with an IC50 of 0.59 μM (PAF-induced platelet aggregation) and a Ki of 5.4 μM (Histamine H₁ receptor binding). Sch-40338 can be used for the study of allergic disease .
Cat. No.: HY-W714099
CAS No.: 99103-16-9
U 66985 is a platelet-activating factor (PAF) receptor antagonist. U 66985 binds to the PAF receptor site, thereby inhibiting PAF-induced platelet aggregation. U 66985 can be used in studies on the PAF signaling pathway and the functions of lipid inflammatory mediators .
Cat. No.: HY-P11549
CAS No.: 663933-94-6
Target:
Cat. No.: HY-118915
CAS No.: 50655-20-4
Synonyms: A26771E
Category:
Target:
Cat. No.: HY-165441
CAS No.: 94415-03-9
Target:
연구분야:
R-836 is an orally active bronchodilator. R-836 is also a weak phosphodiesterase inhibitor. R-836 can reduce bronchoconstriction caused by antigens or platelet-activating factor. R-836 prevents asphyxiation or dyspnea .
Cat. No.: HY-157253
CAS No.: 1217458-58-6
Target:
연구분야:
13(S)-HODE is the lipoxygenase metabolite of Linoleic acid (HY-N0729). 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.
Cat. No.: HY-109897R
CAS No.: 100488-87-7
CV-6209 (Standard) is the analytical standard of CV-6209 (HY-109897). This product is intended for research and analytical applications. CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
