![[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P](https://file.medchemexpress.com/product_pic/hy-103544.gif "Click to View [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1133 Results for "
Ca2 sparks
" in MedChemExpress (MCE) Product Catalog:
Products (1133)
1133 Results for "Ca2 sparks" in MCE Product Catalog:
Cat. No.: HY-N0392
CAS No.: 882664-74-6
Cat. No.: HY-N4267
CAS No.: 13060-14-5
Cat. No.: HY-N0392R
CAS No.: 882664-74-6
Cat. No.: HY-P1341
CAS No.: 343268-91-7
Synonyms: Orexin A (17-33) (human, mouse, rat, bovine)
Research Areas:
Cat. No.: HY-B0819
CAS No.: 14816-18-3
Target:
Insecticide Cholinesterase (ChE) Cytochrome P450 Autophagy Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family Caspase COX Keap1-Nrf2 TNF Receptor Interleukin Related Bacterial
Research Areas:
Phoxim is an organophosphorus pesticide and an orally active inhibitor of cholinesterase and CYP3A, which induces neurotoxicity in Caenorhabditis elegans and causes nephrotoxicity characterized by glomerular atrophy and interstitial fibrosis. Phoxim induces inhibition of the autophagy pathway. Phoxim induces dopaminergic neuron degeneration and exacerbates Aβ-induced paralysis. Phoxim damages enterocytes and disrupts intestinal barrier integrity. Phoxim induces ROS accumulation. Phoxim induces mitochondrial apoptosis, involving upregulation of Bad, Bax, caspase-3, and caspase-9 and downregulation of Bcl-2. Phoxim inhibits mitochondrial functional enzymes (COX, Ca 2+-Mg 2+-ATPase, SDH). Phoxim upregulates Nrf2 mRNA expression in the jejunal mucosa. Phoxim increases TNF-α and decreases IL-6 and IL-8 in the intestinal mucosa. Phoxim alters gut microbial composition by increasing total bacteria and Escherichia coli and reducing Lactobacillus. Phoxim enhances energy metabolism in silver carp by upregulating key glycolytic and gluconeogenic enzymes. Phoxim is used in research on neurodegenerative diseases, nephrotoxicity, intestinal oxidative stress and barrier dysfunction, and bacterial sepsis [2] .
Cat. No.: HY-108659
CAS No.: 202982-98-7
Research Areas:
NF340 is a P2Y11 receptor inhibitor with a pIC50 of 7.3-7.7 against human P2Y11 receptor, and it exhibits high selectivity over other P2Y family receptors. NF340 binds to the ATP-binding amino acid residues of the P2Y11 receptor to inhibit its activity, block nociceptive activity, and reduce spinal dorsal horn P2Y11 receptor upregulation induced by spinal nerve injury. NF340 attenuates the NFκB signaling pathway activated by IL-1β by decreasing IκBα phosphorylation, nuclear p65 accumulation, and NFκB promoter activity. NF340 inhibits IL-1β-induced pro-inflammatory cytokine expression, reduces intracellular ROS and 4-HNE levels, and suppresses IL-1β-induced matrix metalloproteinase expression in primary fibroblast-like synoviocytes. NF340 inhibits ATP-induced elevation of intracellular Ca 2+ concentration and cell migration in human hepatocellular carcinoma cells. NF340 can be used in the research of neuropathic pain, myocardial ischemia/reperfusion injury, inflammatory pain, rheumatoid arthritis, and hepatocellular carcinoma [2] .
Cat. No.: HY-12292G
CAS No.: 1129669-05-1
Cat. No.: HY-P0221S
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38-13C5,15N TFA
Target:
Isotope-Labeled Compounds PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel
Research Areas:
PACAP (1-38), human, ovine, rat- 13C5, 15N (Pituitary Adenylate Cyclase Activating Polypeptide 38- 13C5, 15N) TFA is the 13C, 15N-labeled PACAP (1-38), human, ovine, rat (TFA) (HY-P0221A). PACAP (1-38), human, ovine, rat TFA is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat TFA binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat TFA increases the α-secretase activity. PACAP (1-38), human, ovine, rat TFA elevates cytosolic Ca 2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat TFA can be used for neurotrophic and neuroprotective research [2] .
Cat. No.: HY-W758414
Phoxim-d5 (phenyl-d5) (mixture of isomers) is the deuterated-labeled Phoxim (HY-B0819). Phoxim is an organophosphorus pesticide and an orally active inhibitor of cholinesterase and CYP3A, which induces neurotoxicity in Caenorhabditis elegans and causes nephrotoxicity characterized by glomerular atrophy and interstitial fibrosis. Phoxim induces inhibition of the autophagy pathway. Phoxim induces dopaminergic neuron degeneration and exacerbates Aβ-induced paralysis. Phoxim damages enterocytes and disrupts intestinal barrier integrity. Phoxim induces ROS accumulation. Phoxim induces mitochondrial apoptosis, involving upregulation of Bad, Bax, caspase-3, and caspase-9 and downregulation of Bcl-2. Phoxim inhibits mitochondrial functional enzymes (COX, Ca 2+-Mg 2+-ATPase, SDH). Phoxim upregulates Nrf2 mRNA expression in the jejunal mucosa. Phoxim increases TNF-α and decreases IL-6 and IL-8 in the intestinal mucosa. Phoxim alters gut microbial composition by increasing total bacteria and Escherichia coli and reducing Lactobacillus. Phoxim enhances energy metabolism in silver carp by upregulating key glycolytic and gluconeogenic enzymes. Phoxim is used in research on neurodegenerative diseases, nephrotoxicity, intestinal oxidative stress and barrier dysfunction, and bacterial sepsis [2] .
Target:
Research Areas:
Cat. No.: HY-P71742Y
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78; Heat Shock Protein 70 Family Protein 5; Epididymis Secretory Sperm Binding Protein Li 89n; Heat Shock Protein Family A Member 5; Endoplasmic Reticulum Chaperone BIP; Endoplasmic Reticulum Chaperone BiP; HEL-S-89n; 78 KDa Glucose-Regulated Protein; GRP-78; Binding-Immunoglobulin Protein; Heat Shock Protein Family A (Hsp70) Member 5; Glucose-Regulated Protein, 78kDa
Species:
Mouse
Source:
P. pastoris
Cat. No.: HY-P705465
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78; Heat Shock Protein 70 Family Protein 5; Epididymis Secretory Sperm Binding Protein Li 89n; Heat Shock Protein Family A Member 5; Endoplasmic Reticulum Chaperone BIP; Endoplasmic Reticulum Chaperone BiP; HEL-S-89n; 78 KDa Glucose-Regulated Protein; GRP-78; Binding-Immunoglobulin Protein; Heat Shock Protein Family A (Hsp70) Member 5; Glucose-Regulated Protein, 78kDa
Species:
Human
Source:
E. coli
Cat. No.: HY-P705984
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA5; Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa); Prev. GRP78; HSP70 Family Protein 5; BiP; Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD); Immunoglobulin Heavy Chain-Binding Protein; Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78; Heat Shock Protein 70 Family Protein 5; Epididymis Secretory Sperm Binding Protein Li 89n; Heat Shock Protein Family A Member 5; Endoplasmic Reticulum Chaperone BIP; Endoplasmic Reticulum Chaperone BiP; HEL-S-89n; 78 KDa Glucose-Regulated Protein; GRP-78; Binding-Immunoglobulin Protein; Heat Shock Protein Family A (Hsp70) Member 5; Glucose-Regulated Protein, 78kDa
Species:
Others
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
