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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
164 Results for "
GPCR multimer
" in MedChemExpress (MCE) Product Catalog:
Products (164)
164 Results for "GPCR multimer" in MCE Product Catalog:
Cat. No.: HY-P702040
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC52A1; Porcine Endogenous Retrovirus A Receptor 2; Prev. GPR172B; PERV-A Receptor 2; HRFT1; FLJ10060; PAR2; HuPAR-2; Riboflavin Transporter 1; RFT1; GPCR42; G-Protein Coupled Receptor GPCR42; RFVT1; Riboflavin Transporter; Solute Carrier Family 52 (Ribo
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-101483R
CAS No.: 674786-20-0
Target:
Research Areas:
Dihydromunduletone (Standard) is the analytical standard of Dihydromunduletone (HY-101483). This product is intended for research and analytical applications. Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs .
Cat. No.: HY-N2127A
CAS No.: 75291-74-6
Synonyms: (±)-Pinostrobin
Cat. No.: HY-P706248
Purity: ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: G protein-coupled receptor family C group 6 member A; hGPRC6A; G protein-coupled receptor GPCR33 (hGPCR33); GPRC6A
Species:
Human
Source:
E. coli
Cat. No.: HY-183050
CAS No.: 3036387-75-1
Research Areas:
HEP-50768 is an orally active and selective MRGPRX4 (hX4) antagonist. HEP-50768 suppresses basal and bile-acid-stimulated hX4 activity. HEP-50768 binds the receptor’s transmembrane pocket and induces extracellular loop rearrangements. HEP-50768 modulates GPCR microswitch motifs and reduces bile-acid-induced pruritic scratching behaviors. HEP-50768 can be used for the research of cholestatic pruritus .
Target:
Research Areas:
Chlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease .
Cat. No.: HY-110098R
CAS No.: 1110781-88-8
Synonyms: EPPTB (Standard)
Research Areas:
Ro 5212773 (Standard) is the analytical standard of Ro 5212773 (HY-110098). This product is intended for research and analytical applications. Ro 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids .
Cat. No.: HY-W725737
CAS No.: 944313-05-7
Target:
Research Areas:
BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior .
Cat. No.: HY-L099
2,294 compounds
MCE Targeted Diversity Library contains 2,294 compounds, covering more than 1000 targets and isoforms, such as GPCRs, Ion channel, variety of kinases, etc. 1-3 compounds with high potency and selectivity were carefully selected for each target and isoform. The bioactivity information of each compound has been clearly reported in the literatures. This library is a concise collection of small molecule compounds with comprehensive target coverage, which can be used for phenotypic screening at low cost.
Cat. No.: HY-P706157
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR6; Gonadotropin Receptor; Leucine Rich Repeat Containing G Protein-Coupled Receptor 6; VTS20631; Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6; GPCR; FLJ14471
Species:
Human
Source:
HEK293
Cat. No.: HY-P991761
Target:
Research Areas:
Cat. No.: HY-101008
CAS No.: 133399-65-2
Research Areas:
3-MPPI is a GPCR ligand with high selectivity for α1-adrenergic receptor, with a Ki value of 0.21 nM for α1-adrenergic receptor and 50 nM for 5-HT1A receptor. 3-MPPI modulates the α1-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia .
Cat. No.: HY-13771S1
CAS No.: 63296-46-8
Synonyms: Ursodeoxycholate-13C; Ursodiol-13C; UDCA-13C
Cat. No.: HY-187642
CAS No.: 303059-39-4
Research Areas:
IGGi-11 is a competitive Gαi inhibitor with a Kd of 5.3 μM for sGαi3. IGGi-11 binds to the GIV interaction region of Gαi3, blocks non-canonical G protein signaling, and does not interfere with Gαi nucleotide processing, Gβγ binding, GPCR activation, or effector regulation. IGGi-11 inhibits the pro-invasive properties of metastatic breast cancer. IGGi-11 can be used in related studies on metastatic breast cancer .
Cat. No.: HY-W783254
CAS No.: 799279-67-7
Synonyms: PA(18:0e/0:0)
Research Areas:
C18 LPA (PA(18:0e/0:0)) is a water-soluble phospholipid that functions as a signaling molecule, influencing various cellular responses through G protein-coupled receptors (GPCRs). It is known to promote smooth muscle contraction, cytoskeletal rearrangement, and chemotaxis, while also playing a role in neurotransmitter release, cell proliferation, platelet aggregation, and Ca2+ mobilization. Elevated levels of C18 LPA in human plasma are associated with ovarian cancer and atherosclerosis, suggesting its potential as a biomarker for ovarian cancer.
Cat. No.: HY-107579R
CAS No.: 72420-38-3
Synonyms: AY 25712 (Standard)
Target:
Cat. No.: HY-107625AR
CAS No.: 1781934-47-1
Target:
Research Areas:
SNAP 94847 hydrochloride (Standard) is the analytical standard of SNAP 94847 (hydrochloride) (HY-107625A). This product is intended for research and analytical applications. SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .
Cat. No.: HY-168997
Target:
Research Areas:
CB1R agonist 1 is a potent, CNS-penetrant, and selective Cannabinoid-1 receptor (CB1R) agonist with a Ki of 0.95 nM, modulating Gi/o signaling. CB1R agonist 1 exhibits high selectivity over CB2R and other off-target GPCRs, including GPR55, GPR18, and GPR119. CB1R agonist 1 induces analgesia and hypothermia, and potentiates opioid analgesia in mice. CB1R agonist 1 can be used for the research of pain .
Cat. No.: HY-P10365
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
