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Art. -Nr.: HY-N2127A

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(Rac)-Pinostrobin

Name: (Rac)-Pinostrobin
Brand: MedChemExpress
SKU: HY-N2127A
Availability: PreOrder

(Synonyms: (±)-Pinostrobin)

(Rac)-Pinostrobin ((±)-Pinostrobin) is a dual agonist of TGR5 and PPARγ. (Rac)-Pinostrobin specifically activates TGR5 without acting on other endogenously expressed GPCRs. (Rac)-Pinostrobin exhibits moderate PPARγ activation activity. (Rac)-Pinostrobin possesses metabolic regulatory activity. (Rac)-Pinostrobin can be used in research related to obesity and type 2 diabetes.

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CAS. Nr.: 75291-74-6
Formel: C₁₆H₁₄O₄
Molecular Weight:270.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Pinostrobin Chemical Structure

CAS. Nr.: 75291-74-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

TGR5

PPARγ

Alle PPAR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	37.46 μM Compound: 84	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method	[PMID: 37683361]
J774.A1	IC₅₀	19.63 μM Compound: 84	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method	[PMID: 37683361]
RAW264.7	IC₅₀	22 μM Compound: 84	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of TNF-alpha production incubated for 18 hrs by ELISA analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of TNF-alpha production incubated for 18 hrs by ELISA analysis	[PMID: 37683361]
RAW264.7	IC₅₀	40 μM Compound: 84	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of IL-1beta level incubated for 18 hrs by ELISA analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of IL-1beta level incubated for 18 hrs by ELISA analysis	[PMID: 37683361]
RAW264.7	IC₅₀	23.51 μM Compound: 84	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method	[PMID: 37683361]
RAW264.7	IC₅₀	17.28 μM Compound: 84	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method	[PMID: 37683361]

In Vitro

(Rac)-Pinostrobin ((±)-Pinostrobin) (13-100 μM; up to 40 h) activates TGR5 in TGR5-expressing HepG2 cells, producing significant, dose-dependent activation across concentrations from 13 to 100 μM^[1].
(Rac)-Pinostrobin (13-100 μM; up to 40 h) acts as a modest PPARγ activator in A9 cells, producing significant activation only at concentrations from 13 to 44 μM, with no detectable activity at higher concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 75291-74-6
Molecular Weight 270.28
Formel C₁₆H₁₄O₄
SMILES

O=C1C=2C(O)=CC(OC)=CC2OC(C=3C=CC=CC3)C1
Synonyms

(±)-Pinostrobin
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related

Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Miyata R, et al. Takeda G Protein-Coupled Receptor 5 and Peroxisome Proliferator-Activated Receptor-Gamma Activation by Pinocembrin and Pinostrobin Isolated from Lindera sericea. Int J Mol Sci. 2026 Feb 22;27(4):2045.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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