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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1537 Results for "
D2
" in MedChemExpress (MCE) Product Catalog:
Products (1537)
1537 Results for "D2" in MCE Product Catalog:
Cat. No.: HY-111136
CAS No.: 916898-61-8
Research Areas:
BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate .
Cat. No.: HY-156158
CAS No.: 2749568-16-7
Target:
Research Areas:
IDH2 R140Q-IN-2 (compound 36) is an an orally active IDH2 R140Q inhibitor (IC50: 29 nM). IDH2 R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2 R140Q (IC50: 10 nM). IDH2 R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2 R140Q-IN-2 can be used for research of acute myeloid leukemia (AML) .
Cat. No.: HY-151079S
CAS No.: 1219798-92-1
Cat. No.: HY-B0400S7
CAS No.: 1931877-16-5
Synonyms: Sorbitol-d1-2; D-Glucitol-d1-2
Cat. No.: HY-W142446S
CAS No.: 1219804-28-0
Target:
Research Areas:
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC50 of 2 nM.
c-Fms-IN-10 has anti-tumor activity .
Cat. No.: HY-P0323
CAS No.: 161928-86-5
Synonyms: LCMV GP(33-41) C-peptide
Target:
Research Areas:
Cat. No.: HY-W654003
Synonyms: Disodium (R)-2-hydroxyglutarate-d5
Cat. No.: HY-14545B
CAS No.: 2974362-88-2
Target:
Research Areas:
SEP4199 is an orally active 5-HT7 receptor ligand, with a Ki value of 66 nM for human 5-HT7R and 16 nM for human D2R. SEP4199 mediates antidepressant effects. SEP4199 is applicable for the research of bipolar depression .
Cat. No.: HY-187696
CAS No.: 2349365-88-2
Target:
Research Areas:
MS1768 is a G protein-biased, partial, and selective D2R agonist. MS1768 selectively activates the Gi/o signaling pathway rather than recruiting β-arrestin2. MS1768 inhibits hyperkinesia. MS1768 can be used in studies of hyperkinesia .
Cat. No.: HY-W025785S1
Synonyms: Solvent Yellow 2-d6; Dimethyl yellow-d6
Cat. No.: HY-W547534
CAS No.: 2307-55-3
Synonyms: 2,4-Dichlorophenoxyacetic acid ammonium
Target:
Research Areas:
2,4-D (2, 4-dichlorophenoxyacetic acid) ammonium is a selective herbicide that can be used for the control of broad-leaved weeds. 2,4-D ammonium can induce apoptosis. 2,4-D ammonium inhibits DNA and protein synthesis, thereby preventing normal plant growth and development [2] .
Cat. No.: HY-112704
CAS No.: 2244517-61-9
Target:
Research Areas:
PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity .
Cat. No.: HY-14881S2
Cat. No.: HY-187147
CAS No.: 342379-28-6
Target:
Research Areas:
NMDAR modulator 3 is a subunit-selective NMDA receptor potentiator targeting NMDAR receptors containing NR2C/NR2D subunits. NMDAR modulator 3 can be used for the research of schizophrenia, parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, neurodegeneration .
Cat. No.: HY-122277
CAS No.: 57704-16-2
Synonyms: Ro 03-7410
Target:
Research Areas:
1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity [2].
Cat. No.: HY-155960
CAS No.: 2975285-28-8
Research Areas:
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .
Cat. No.: HY-34763
CAS No.: 70500-72-0
Synonyms: 7-Hydroxyquinolinone; 2,7-Dihydroxyquinoline
Target:
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7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) (Compound 7) is a quinolinone derivative. 7-Hydroxycarbostyril can be used for synthesis of Brexpiprazole (HY-15780). Brexpiprazole, a typical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor .
Cat. No.: HY-184004
Research Areas:
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma .
Cat. No.: HY-179639
Target:
Research Areas:
PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PED4D2, targeting PDE4 through halogen bonding and metal coordination. PDE4-IN-30 exhibits at least 67-fold selectivity for other PDE subfamilies. PDE4-IN-30 can be used for the research of idiopathic pulmonary fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
