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Acridone

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By Targets:	Apoptosis (1) Bacterial (3) Bcl-2 Family (2) BCRP (2) Biochemical Assay Reagents (2) CDK (1) Cytochrome P450 (2) Drug Derivative (1) EBV (1) Fluorescent Dye (1) Monoamine Oxidase (2) PARP (2) Reference Standards (2) Survivin (2) Syk (2) Topoisomerase (4)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (4) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1311

Proadifen hydrochloride 1 Publications Verification SKF-525A; U-5446; RP-5171	Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC₅₀ value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases .

HY-W007771

*Acridone*	Bacterial BCRP	Infection Cancer
Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .

HY-34887

Acridone-4-carboxylic acid	Drug Derivative	Others
Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC₅₀ of 43 μM .

HY-W415108

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate	Fluorescent Dye	Others
10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .

HY-N9147

1-Hydroxy-N-methylacridone	Others	Neurological Disease
1-Hydroxy-N-methylacridone is an acridone alkaloid from Boronia lanceolate .

HY-W007771R

Acridone (Standard)	Reference Standards Bacterial BCRP	Infection Cancer
Acridone (Standard) is the analytical standard of Acridone. This product is intended for research and analytical applications. Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .

HY-N15629

Melicopicine NSC 402921	Biochemical Assay Reagents	Others
Melicopicine (NSC 402921) (Compound 2) is an acridone alkaloid. Melicopicine is a 1,2,3,4-tetraoxygenated acridone precursor, which can be co-isolated from S. megistophylla and detected by GC-MS in the extract from S. follicularis .

HY-138961

ER-27319 1 Publications Verification	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-171481

Thio-acridone SACD	CDK	Cancer
Thio-acridone (SACD) is a photosensitizer (HAF-PSs). Thio-acridone forms a long-lived triplet state upon excitation by 470 nm visible light,, ultimately generating singlet oxygen to damage the structures and functions of target cells such as cancer cells. Thio-acridone is promising for research of cancers . Thio-acridone is a CDK4/Cyclin D1 inhibitor (IC50 = 2 uM) .

HY-143279

Topoisomerase II inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC₅₀ is 0.17 μM for topo IIα and the value of IC₅₀ is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential .

HY-147182

3,6-Diamino-9(10H)-acridone	Topoisomerase	Others
3,6-Diamino-9(10H)-acridone is a topoisomerase inhibitor .

HY-N15597

Melicopidine NSC 34757	Topoisomerase	Cancer
Melicopidine (NSC 34757) is a DNA topoisomerase inhibitor, which is an acridone alkaloid found in the bark of Medicosma subsessilis. Melicopidine exerts potential antitumor activity by binding to DNA or inhibiting related enzyme activity .

HY-128913

1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one	Bacterial	Infection
1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one is an acridone alkaloid compound isolated from the fruits of Z. leprieurii and Z. zanthoxyloides. 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has antibacterial activity .

HY-B1311R

Proadifen hydrochloride (Standard) SKF-525A (Standard); U-5446 (Standard); RP-5171 (Standard)	Reference Standards Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (hydrochloride) (Standard) is the analytical standard of Proadifen (hydrochloride). This product is intended for research and analytical applications. Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases [4] .

HY-108489

ER-27319 maleate 1 Publications Verification	Syk	Inflammation/Immunology
ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-W748415

Acronycine Acronine	Others	Others
Acronycine (Acronine) is an acridone alkaloid .

HY-N17355

Des-N-methylnoracronycine	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Des-N-methylnoracronycine is an acridone alkaloid found in the root bark of Glycosmis pentaphylla (Retz.) Correa. Des-N-methylnoracronycine has antitumor and platelet aggregation inhibitory activities .

HY-N17354

Glycocitrine II	EBV	Infection
Glycocitrine II is an acridone alkaloid. Glycocitrine II can be isolated from the Rutaceous plants. Glycocitrine II inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced EBV-EA activation .

Cat. No.	Product Name	Type

HY-W415108

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate	Fluorescent Dyes
10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate

Fluorescent Dyes

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .

*Acridone*	Infection Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification	Bacterial BCRP
Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .

1-Hydroxy-N-methylacridone	Rutaceae Plants Pteris livida Mett. Source Classification	Others
1-Hydroxy-N-methylacridone is an acridone alkaloid from Boronia lanceolate .

Acridone (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Bacterial BCRP
Acridone (Standard) is the analytical standard of Acridone. This product is intended for research and analytical applications. Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .

Melicopicine NSC 402921	Alkaloids Other Alkaloids Rubiaceae Coussarea megistophylla Plants Source Classification	Biochemical Assay Reagents
Melicopicine (NSC 402921) (Compound 2) is an acridone alkaloid. Melicopicine is a 1,2,3,4-tetraoxygenated acridone precursor, which can be co-isolated from S. megistophylla and detected by GC-MS in the extract from S. follicularis .

Melicopidine NSC 34757	Alkaloids Other Alkaloids Rutaceae Medicosma subsessilis T.G.Hartley Plants Source Classification	Topoisomerase
Melicopidine (NSC 34757) is a DNA topoisomerase inhibitor, which is an acridone alkaloid found in the bark of Medicosma subsessilis. Melicopidine exerts potential antitumor activity by binding to DNA or inhibiting related enzyme activity .

Acronycine Acronine	Structural Classification Alkaloids Glycosmis arborea (Retz.) Corrêa Rutaceae Acridone Alkaloids Plants Source Classification	Others
Acronycine (Acronine) is an acridone alkaloid .

Des-N-methylnoracronycine	Structural Classification Alkaloids Glycosmis arborea (Retz.) Corrêa Other Alkaloids Rutaceae Plants Source Classification	Biochemical Assay Reagents
Des-N-methylnoracronycine is an acridone alkaloid found in the root bark of Glycosmis pentaphylla (Retz.) Correa. Des-N-methylnoracronycine has antitumor and platelet aggregation inhibitory activities .

Glycocitrine II	Glycosmis parviflora Kurz. Structural Classification Monophenols Rutaceae Phenols Plants Source Classification	EBV
Glycocitrine II is an acridone alkaloid. Glycocitrine II can be isolated from the Rutaceous plants. Glycocitrine II inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced EBV-EA activation .

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Acridone

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Natural
Products