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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Antiapoptotic function
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Antiapoptotic function" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-N0058
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C; 4,5-diCQA
Category:
Infection Ketones, Aldehydes, Acids Phenols Polyphenols Plants Bowdichia virgilioides Compositae Endogenous metabolite Disease Research Fields
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1
Category:
other families Microorganisms Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields
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1 Cited Publications
Cat. No.: HY-N6850
CAS No.: 26020-14-4
1
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Cat. No.: HY-101083
CAS No.: 1909226-00-1
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BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .
Cat. No.: HY-W067056
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate
Category:
other families Simple Phenylpropanols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N0408R
CAS No.: 39012-20-9
Cat. No.: HY-N0058R
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C (Standard); 4,5-diCQA (Standard)
Cat. No.: HY-W067056S1
CAS No.: 2022152-96-9
Synonyms: Methyl(E)-3-phenylpropenoate-d7
Cat. No.: HY-161577
CAS No.: 701231-39-2
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BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .
Cat. No.: HY-101083A
CAS No.: 142645-19-0
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(Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .
Cat. No.: HY-W067056R
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate (Standard)
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Cat. No.: HY-W067056S
CAS No.: 61764-82-7
Synonyms: Methyl(E)-3-phenylpropenoate-d5
Cat. No.: HY-184443
CAS No.: 3119834-80-6
Target:
Microtubule/Tubulin Bcl-2 Family Apoptosis MDM-2/p53 Mitochondrial Metabolism Reactive Oxygen Species (ROS)
Research Areas:
Bcl-2-IN-26 is an inhibitor targeting β-tubulin and BCL-2. Bcl-2-IN-26 disrupts the intracellular microtubule network and interferes with cell mitosis, inducing G2/M phase cell cycle arrest. Bcl-2-IN-26 suppresses antiapoptotic BCL-2 function via p53 upregulation, thereby triggering mitochondrial dysfunction, elevated ROS production and robust tumor cell apoptosis. Bcl-2-IN-26 can be used in lung cancer research .
Cat. No.: HY-181018
CAS No.: 3040940-61-9
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Topo I/DDX5-IN-1 (Compound A10) is a Topo I and DDX5 inhibitor. Topo I/DDX5-IN-1 inhibits Topo I activity, binds to DDX5, and suppresses DDX5 function. Topo I/DDX5-IN-1 increases expression of γ-H2AX and p21, suppresses the expression of antiapoptotic proteins (Bcl-2 and XIAP), stimulates ROS generation, and triggers Apoptosis. Topo I/DDX5-IN-1 exhibits anticancer activity against pancreatic cancer, non-small cell lung cancer, skin cancer, and colorectal cancer .
Cat. No.: HY-N18905
CAS No.: 161713-86-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
