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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Antiapoptotic function
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Antiapoptotic function" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-N0058
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C; 4,5-diCQA
Category:
Infection Plant Ketones, Aldehydes, Acids Phenols Polyphenols Compositae/Asteraceae Extract Endogenous metabolite Disease Research Fields Erigeron breviscapus Extract
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2
Category:
Plant Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Other Families Extract Disease Research Fields
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2
2 Cited Publications
Synonyms: APG-2575; Bcl-2/Bcl-xl inhibitor 1
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Research Areas:
Lisaftoclax is an orally active, selective BCL-2 inhibitor with a Ki of < 0.1 nM against human BCL-2. Lisaftoclax selectively binds to BCL-2, disrupts the BCL-2:BIM complex, and antagonizes the antiapoptotic function of BCL-2. Lisaftoclax induces BAX/BAK-dependent, caspase-mediated apoptosis, upregulates the pro-death proteins BIM and Noxa, and downregulates mitochondrial respiratory function and ATP production. Lisaftoclax can be used in the research of hematological malignancies including chronic lymphocytic leukemia, multiple myeloma, and diffuse large B-cell lymphoma .
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1 Cited Publications
Cat. No.: HY-N6850
CAS No.: 26020-14-4
1
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Cat. No.: HY-101083
CAS No.: 1909226-00-1
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Research Areas:
BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .
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Cat. No.: HY-W067056
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate
Category:
Plant Simple Phenylpropanols Phenylpropanoids Other Families Extract Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N0408R
CAS No.: 39012-20-9
Cat. No.: HY-N0058R
CAS No.: 57378-72-0
Synonyms: Isochlorogenic acid C (Standard); 4,5-diCQA (Standard)
Cat. No.: HY-W067056S1
CAS No.: 2022152-96-9
Synonyms: Methyl(E)-3-phenylpropenoate-d7
Cat. No.: HY-161577
CAS No.: 701231-39-2
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BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .
Cat. No.: HY-P1733
Synonyms: BMF-Y
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Research Areas:
BMf-BH3 (BMF-Y) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 can be used in cancer-related research .
Cat. No.: HY-101083A
CAS No.: 142645-19-0
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(Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .
Cat. No.: HY-P1733A
Synonyms: BMF-Y TFA
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Research Areas:
BMf-BH3 TFA (BMF-Y TFA) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 TFA binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 TFA can be used in cancer-related research .
Cat. No.: HY-W067056R
CAS No.: 1754-62-7
Synonyms: Methyl (E)-3-phenylpropenoate (Standard)
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Cat. No.: HY-W067056S
CAS No.: 61764-82-7
Synonyms: Methyl(E)-3-phenylpropenoate-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
