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Results for "

B12

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Antibiotic (1) Antifolate (1) Autophagy (1) Biochemical Assay Reagents (3) CD20 (1) Cytochrome P450 (4) Drug Derivative (2) Drug Intermediate (2) Drug Metabolite (1) Endogenous Metabolite (25) Environmental Pollutants (1) Fungal (1) GABA Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JNK (1) Liposome (1) NF-κB (1) NO Synthase (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) RAR/RXR (1) Reference Standards (6) Small Interfering RNA (siRNA) (5) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (9) Metabolic Disease (22) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Liposome (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

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Fluorescent Dyes

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Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0315

Vitamin B12 3 Publications Verification Cyanocobalamin	Environmental Pollutants Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies .

HY-B0586

Methylcobalamin 5 Publications Verification Mecobalamin; CH3-B12	Endogenous Metabolite	Metabolic Disease
Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

HY-112790

Adenosylcobalamin 1 Publications Verification Coenzyme B12; Cobamamide; AdoCbl	Endogenous Metabolite	Metabolic Disease
Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-103395

Methylmalonic acid 3 Publications Verification Methylpropanedioic acid; Methylmalonate	Endogenous Metabolite	Cancer
Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Endogenous Metabolite	Neurological Disease Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-B2209A

Hydroxocobalamin monohydrochloride 3 Publications Verification Vitamin B12a monohydrochloride	Endogenous Metabolite	Metabolic Disease
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia .

HY-B2209

Hydroxocobalamin 3 Publications Verification Vitamin B12a	Endogenous Metabolite	Neurological Disease Metabolic Disease
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

HY-B0315R

*Vitamin B12* (Standard)** Cyanocobalamin (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
Vitamin B12 (Standard) is the analytical standard of Vitamin B12. This product is intended for research and analytical applications. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .

HY-B2209B

Hydroxocobalamin acetate 3 Publications Verification Vitamin B12a acetate	NO Synthase	Cardiovascular Disease Metabolic Disease
Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .

HY-B0315A

Biotin-Vitamin B12 Biotin-Cyanocobalamin B12	Endogenous Metabolite	Metabolic Disease
Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas .

HY-W040821

DL-Homocysteine 4 Publications Verification	Endogenous Metabolite	Neurological Disease
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-17383

Levomefolate calcium 3 Publications Verification	Antifolate	Cardiovascular Disease Neurological Disease
Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

HY-113092

Propionylcarnitine	Endogenous Metabolite	Metabolic Disease
Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency .

HY-79139

Pteroic acid 1 Publications Verification	Drug Intermediate	Metabolic Disease
Pteroic acid is a precursor to significant compounds like Folic acid (HY-16637) and Vitamin B12 (HY-B0315). Pteroic acid facilitates the examination of how different compounds influence cell growth and development .

HY-B0315B

*Vitamin B12* hydrate** 3 Publications Verification Cyanocobalamin hydrate	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Vitamin B12 (Cyanocobalamin) hydrate is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 hydrate is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies .

HY-112790R

Adenosylcobalamin (Standard) Coenzyme B12 (Standard); Cobamamide (Standard); AdoCbl (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Adenosylcobalamin (Standard) is the analytical standard of Adenosylcobalamin. This product is intended for research and analytical applications. Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-B0315S

*Vitamin B12-13C7* Cyanocobalamin-¹³C₇	Endogenous Metabolite	Metabolic Disease
Vitamin B12- ¹³C₇ is the ¹³C-labeled Vitamin B12. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .

HY-B0586R

Methylcobalamin (Standard) Mecobalamin (Standard); CH3-B12 (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Methylcobalamin (Standard) is the analytical standard of Methylcobalamin. This product is intended for research and analytical applications. Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

HY-D1056A4

Lipopolysaccharides, from E. coli O128:B12 LPS, from Escherichia coli (O128:B12)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from E. coli O128:B12 (LPS, from Escherichia coli (O128:B12)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O128:B12) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O128:B12 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O128:B12 activate TLR-4 in immune cells, can be used to construct animal models of neonatal brain inflammation, and may influence preterm birth in neonates . It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-161456

PHGDH-IN-5	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC₅₀ value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells .

HY-114376

Borocaptate-10B12 sodium BSH-¹⁰B₁₂	Isotope-Labeled Compounds Biochemical Assay Reagents	Cancer
Borocaptate-10B12 (BSH-10B12) sodium is a boron-10 labeled Borocaptate (HY-142041). Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity .

HY-103395S1

Methylmalonic acid-13C4	Endogenous Metabolite	Cancer
Methylmalonic acid- ¹³C₄ is the ¹³C labeled Methylmalonic acid . Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-126791A

Methylmalonyl-CoA tetralithium Isosuccinyl coenzyme A tetralithium; Methylmalonyl coenzyme tetralithium	Endogenous Metabolite	Others
Methylmalonyl-CoA (Methylmalonyl coenzyme A) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl-CoA tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .

HY-B1042

Oxolamine citrate SKF-9976 citrate; AF-438 citrate	Cytochrome P450	Inflammation/Immunology
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive. Oxolamine citrate can inhibit *CYP2B1/2*. Oxolamine citrate has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine citrate increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine citrate can be used in respiratory disease research .

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Endogenous Metabolite	Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-103395R

Methylmalonic acid (Standard) Methylpropanedioic acid (Standard); Methylmalonate (Standard)	Reference Standards Endogenous Metabolite	Cancer
Methylmalonic acid (Standard) is the analytical standard of Methylmalonic acid. This product is intended for research and analytical applications. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-103395S

Methylmalonic acid-d3 Methylpropanedioic acid-d₃; Methylmalonate-d₃	Endogenous Metabolite	Cancer
Methylmalonic acid-d₃ is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-W778830

Bodipy C12-ceramide	Drug Metabolite	Neurological Disease
Bodipy C12-ceramide (B12Cer) is a fluorescently tagged form of C12-Ceramide (HY-100353) that displays excitation/emission maxima of 505/540 nm, respectively. Bodipy C12-ceramide is formed when acid sphingomyelinase hydrolyzes BODIPY-C12 sphingomyelin in vitro and has been used to quantify acid sphingomyelinase activity in plasma with Niemann-Pick disease .

HY-177825

Liposomal Vitamin B12	Liposome	Metabolic Disease
Liposomal Vitamin B12 is a specialized delivery system that encapsulates vitamin B12 within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of vitamin B12. Vitamin B12 (cyanocobalamin) is a water-solu

HY-113045

Aquacobalamin	Endogenous Metabolite	Metabolic Disease
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO₅ ^- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .

HY-154992

2,4-Difluorophenylethynylcobalamin F2PhEtyCbl	Others	Others
2,4-Difluorophenylethynylcobalamin is a potential *B12* antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH) . 2,4-Difluorophenylethynylcobalamin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139036

Dicyanocobinamide	Biochemical Assay Reagents	Others
Dicyanocobinamide is a precursor to vitamin B12. Dicyanocobinamide is a catalyst for the oxidation of peptides, which is utilized for a rapid, environmentally friendly method of disulfide bond formation in water. Dicyanocobinamide exhibits good biocompatibility .

HY-RS06392

HSD17B12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSD17B12 Human Pre-designed siRNA Set A contains three designed siRNAs for HSD17B12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSD17B12 Human Pre-designed siRNA Set A HSD17B12 Human Pre-designed siRNA Set A

HY-133739

NBD-125	RAR/RXR	Cancer
NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell .

HY-N13061

Nervon	Others	Neurological Disease
Nervon is a crystalline cerebroside. Nervon can be used for the research of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency .

HY-156796

Akt/ROCK-IN-1	ADC Payload	Neurological Disease Cancer
Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC₅₀s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma .

HY-149615

Antibacterial agent 157	Fungal	Infection
Antibacterial agent 157 (compound B12) is a fungicidal agent. Antibacterial agent 157 can influence the protein synthesis of Botrytis cinerea. Antibacterial agent 157 can be used for gray mold resistance control research .

HY-137007

SMA-12b	Interleukin Related	Others Inflammation/Immunology
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .

HY-W127737

Methylcobalamin hydrate Mecobalamin hydrate	Biochemical Assay Reagents	Others
Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

HY-79139R

Pteroic acid (Standard)	Reference Standards Drug Intermediate	Metabolic Disease
Pteroic acid (Standard) is the analytical standard of Pteroic acid (HY-79139). This product is intended for research and analytical applications. Pteroic acid is a precursor to significant compounds like Folic acid (HY-16637) and Vitamin B12 (HY-B0315). Pteroic acid facilitates the examination of how different compounds influence cell growth and development .

HY-144761

TOPK-p38/JNK-IN-1	JNK	Cancer
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active TOPK-p38/JNK signaling pathway inhibitor with the IC₅₀ value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK .

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-137936

Terrecyclic Acid	Antibiotic	Infection
Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs=25, 50, and 25 μg/mL, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells.2 In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P388 murine leukemia.

HY-B0315S1

Methylcobalamin-d3 Mecobalamin-d₃; CH3-B12-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Methylcobalamin-d₃ (Mecobalamin-d₃) is the deuterium labeled Methylcobalamin (HY-B0586). Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12 .

HY-148285A

Succinyl CoA disodium Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium	Endogenous Metabolite	Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-W765494

Methylcobalamin-13C,d3 Mecobalamin-¹³C,d₃; CH3-B12-¹³C,d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Methylcobalamin- ¹³C,d₃ (Mecobalamin- ¹³C,d₃) is the ¹³C- and deuterium labeled Methylcobalamin (HY-B0586). Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

HY-W739369

Cyanocobalamin-e-methylamide	Drug Derivative	Cancer
Cyanocobalamin-e-methylamide is a Vitamin B₁₂ (HY-B0315) analogue. Cyanocobalamin-e-methylamide exerts a plasma blocking effect on ⁵⁷Co-cyanocobalamin. Cyanocobalamin-e-methylamide can be used for the research of chronic myelocytic leukaemia .

HY-107078

DTPA-adenosylcobalamin	Drug Derivative	Cancer
DTPA-adenosylcobalamin is an Adenosylcobalamin (HY-112790) and Pentetic acid (HY-B1335) conjugate. DTPA-adenosylcobalamin can used as a radioactive probe for diagnosing the absorption of vitamin B12 in tumor .

HY-RS27177

Hsd17b12 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsd17b12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsd17b12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsd17b12 Rat Pre-designed siRNA Set A Hsd17b12 Rat Pre-designed siRNA Set A

HY-RS20666

Hsd17b12 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsd17b12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsd17b12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsd17b12 Mouse Pre-designed siRNA Set A Hsd17b12 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-B0315A

Biotin-Vitamin B12

Biotin-Cyanocobalamin B12

Fluorescent Dyes

Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas .

Cat. No.	Product Name	Type

HY-D1056A4

Lipopolysaccharides, from E. coli O128:B12

LPS, from Escherichia coli (O128:B12)

Biochemical Assay Reagents

Lipopolysaccharides, from E. coli O128:B12 (LPS, from Escherichia coli (O128:B12)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O128:B12) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O128:B12 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O128:B12 activate TLR-4 in immune cells, can be used to construct animal models of neonatal brain inflammation, and may influence preterm birth in neonates .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-W127737

Methylcobalamin hydrate

Mecobalamin hydrate

Biochemical Assay Reagents

Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

Cat. No.	Product Name

HY-K3004

RPMI 1640 (L-Glutamine, Phenol Red, no HEPES) 4 Publications Verification
RPMI 1640 contains glutathione and high concentration of vitamins, also contains biotin, vitamin B12, 4-Aminobenzoic acid (PABA) not found in MEM and DMEM, as well as high concentration of inositol and choline chloride. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P992060

Anti-Mouse CD20 Antibody (18B12)	CD20 NF-κB	Inflammation/Immunology Cancer
Anti-Mouse CD20 Antibody (18B12) is a B cell depleting agent that targets mouse CD20. Anti-Mouse CD20 Antibody (18B12) not only inhibits the growth of mesothelioma, lung cancer and thymoma, but also significantly enhances the efficacy of adenoviral tumor antigen vaccines and induces tumor regression by increasing the number of tumor-specific CD8 ⁺ T cells. Anti-Mouse CD20 Antibody (18B12) reduces B cell infiltration into the central nervous system of mice with experimental autoimmune encephalomyelitis, and delays motor dysfunction and neuronal death after spinal cord injury by alleviating inflammatory responses and tissue damage. Anti-Mouse CD20 Antibody (18B12) is widely applicable to research in fields related to mesothelioma, lung cancer, thymoma, experimental autoimmune encephalomyelitis and spinal cord injury .

HY-P992056

Anti-Human/Mouse LY6E Antibody (9B12)	Autophagy	Cancer
Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRα and CD8α, specifically reduces the survival rate of peripheral CD8 ⁺ T cells and induces their activation, breaking the state of cellular quiescence; on the other hand, it recognizes and immunoprecipitates IDE under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8 ⁺ T cells strictly depends on the presence of PILRα, and it does not affect CD4 ⁺ T cells or T cell development in the thymus, exhibiting high specificity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0315

Vitamin B12 3 Publications Verification Cyanocobalamin	Structural Classification Natural Products Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies .

HY-B0586

Methylcobalamin 5 Publications Verification Mecobalamin; CH3-B12	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

HY-112790

Adenosylcobalamin 1 Publications Verification Coenzyme B12; Cobamamide; AdoCbl	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-103395

Methylmalonic acid 3 Publications Verification Methylpropanedioic acid; Methylmalonate	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-B2209A

Hydroxocobalamin monohydrochloride 3 Publications Verification Vitamin B12a monohydrochloride	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia .

HY-B2209

Hydroxocobalamin 3 Publications Verification Vitamin B12a	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

HY-B0315R

*Vitamin B12* (Standard)** Cyanocobalamin (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Vitamin B12 (Standard) is the analytical standard of Vitamin B12. This product is intended for research and analytical applications. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .

HY-B2209B

Hydroxocobalamin acetate 3 Publications Verification Vitamin B12a acetate	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	NO Synthase
Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .

HY-B0315A

Biotin-Vitamin B12 Biotin-Cyanocobalamin B12	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas .

HY-W040821

DL-Homocysteine 4 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-113092

Propionylcarnitine	Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency .

HY-112790R

Adenosylcobalamin (Standard) Coenzyme B12 (Standard); Cobamamide (Standard); AdoCbl (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Adenosylcobalamin (Standard) is the analytical standard of Adenosylcobalamin. This product is intended for research and analytical applications. Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-B0586R

Methylcobalamin (Standard) Mecobalamin (Standard); CH3-B12 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Methylcobalamin (Standard) is the analytical standard of Methylcobalamin. This product is intended for research and analytical applications. Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

HY-126791A

Methylmalonyl-CoA tetralithium Isosuccinyl coenzyme A tetralithium; Methylmalonyl coenzyme tetralithium	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Methylmalonyl-CoA (Methylmalonyl coenzyme A) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl-CoA tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-103395R

Methylmalonic acid (Standard) Methylpropanedioic acid (Standard); Methylmalonate (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite	Reference Standards Endogenous Metabolite
Methylmalonic acid (Standard) is the analytical standard of Methylmalonic acid. This product is intended for research and analytical applications. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-113045

Aquacobalamin	Microorganisms Source Classification	Endogenous Metabolite
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO₅ ^- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .

HY-N13061

Nervon	Animals Saccharides Monosaccharides Source Classification	Others
Nervon is a crystalline cerebroside. Nervon can be used for the research of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency .

HY-W040821R

DL-Homocysteine (Standard)	Structural Classification Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Metoprolol acid (Standard) is the analytical standard of Metoprolol acid. This product is intended for research and analytical applications. Metoprolol acid (Atenolol acid) is a urinary metabolite with no pharmacological activity. Metoprolol acid does not exert its pharmacological effects in vivo. Metoprolol acid can be detected by solid phase extraction and reversed phase high performance liquid chromatography. The analysis of metoprolol acid requires specific conditions, such as the use of fluorescence detection and specific eluents .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (1) P. pastoris (1) Sf9 insect cells (1)

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HY-P71304

	*Serpin B12* Protein, Human (HEK293, His)** SERPINB12; Serpin B12; Serine Protease Inhibitor-clade B12	Human	HEK293
	Serpin B12 Protein inhibits trypsin and plasmin, excluding thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. It may have a role in cell differentiation, interacting with SLFN12 in a pathway regulating differentiation, and potentially interacting with USP14. Serpin B12 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B12 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77197

	*Serpin B12* Protein, Mouse (sf9, His)** SERPINB12; Serpin B12; Serine Protease Inhibitor-clade B12	Mouse	Sf9 insect cells
	Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71789

	TCN1 Protein, Human (P.pastoris, His) Haptocorin; Haptocorrin; HC; Transcobalamin 1; Vitamin B12 binding protein; Vitamin B12 binding protein R binder family	Human	P. pastoris
	The TCN1 protein is critical for mitochondrial processes and binds to the mitochondrial light chain promoter to regulate mitochondrial transcription. As a key component of the mitochondrial transcription initiation complex (including TFB2M and POLRMT), TCN1 plays a crucial role in the basal transcription of mitochondrial DNA. TCN1 Protein, Human (P.pastoris, His) is the recombinant human-derived TCN1 protein, expressed by P. pastoris , with N-His labeled tag.

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HY-B0315S

*Vitamin B12-13C7*
Vitamin B12- ¹³C₇ is the ¹³C-labeled Vitamin B12. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .

HY-114376

Borocaptate-10B12 sodium
Borocaptate-10B12 (BSH-10B12) sodium is a boron-10 labeled Borocaptate (HY-142041). Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity .

HY-103395S1

Methylmalonic acid-13C4
Methylmalonic acid- ¹³C₄ is the ¹³C labeled Methylmalonic acid . Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-103395S

Methylmalonic acid-d3
Methylmalonic acid-d₃ is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-B0315S1

Methylcobalamin-d3
Methylcobalamin-d₃ (Mecobalamin-d₃) is the deuterium labeled Methylcobalamin (HY-B0586). Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12 .

HY-W765494

Methylcobalamin-13C,d3
Methylcobalamin- ¹³C,d₃ (Mecobalamin- ¹³C,d₃) is the ¹³C- and deuterium labeled Methylcobalamin (HY-B0586). Methylcobalamin (CH3-B12), a cobalamin, is a form of vitamin B12.

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (2) Mouse (2) Monkey (2)
Application:	IHC-P (1) WB (3) FC (3) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P84669

	Fucokinase Antibody (YA4366) FLJ39408; 1110046B12Rik	WB, FC, ELISA	Human, Mouse, Rat, Monkey
	Fucokinase Antibody (YA4366) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fucokinase.

HY-P84669A

	Fucokinase Antibody (YA4366)(PBS only) FLJ39408; 1110046B12Rik	WB, FC, ELISA	Human, Mouse, Rat, Monkey
	Fucokinase Antibody (YA4366) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fucokinase.

HY-P81760

	C4A Antibody (YA1505) Acidic C4; Acidic complement C4; Basic C4; Basic complement C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4B1; C4B12; C4B2; C4B3; C4BD; C4F; C4S; CPAMD2; CPAMD3	WB, IHC-P, FC	Human
	C4A Antibody (YA1505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C4A.

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