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Results for "

CA II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (14) Calmodulin (1) CaMK (17) Adrenergic Receptor (1) Amyloid-β (2) Androgen Receptor (2) Angiotensin Receptor (3) Antibiotic (2) Apoptosis (8) Atg8/LC3 (1) Autophagy (8) Bacterial (5) Calcineurin (1) Carbonic Anhydrase (59) Caspase (1) CDK (1) Cholinesterase (ChE) (2) COX (2) CRFR (1) Dipeptidyl Peptidase (1) Drug Metabolite (1) EGFR (3) Endogenous Metabolite (3) Environmental Pollutants (1) ERK (4) Ferroptosis (1) Free Fatty Acid Receptor (1) Fungal (1) HDAC (1) Histone Demethylase (1) Interleukin Related (1) Isotope-Labeled Compounds (5) Mineralocorticoid Receptor (2) mTOR (1) Myosin (2) Na+/K+ ATPase (1) NF-κB (2) NKCC (1) NO Synthase (1) NOD-like Receptor (NLR) (1) p62 (1) PACAP Receptor (2) Phosphatase (4) Phosphodiesterase (PDE) (2) PKA (1) PKC (5) Potassium Channel (1) PPAR (2) PROTACs (1) Proteasome (1) Reactive Oxygen Species (ROS) (8) Reference Standards (10) Small Interfering RNA (siRNA) (2) SOD (2) Sodium Channel (3) Src (1) Trk Receptor (1)
By Research Areas:	Cancer (35) Cardiovascular Disease (13) Endocrinology (6) Infection (9) Inflammation/Immunology (11) Metabolic Disease (17) Neurological Disease (40)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

109

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Photosystem II Calcium Channel CRAC Channel Na+/Ca2+ Exchanger CaSR Calmodulin CaMK CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0561

Spironolactone 5+ Cited Publications SC9420	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-B0588

Brinzolamide 5+ Cited Publications AL-4862	Carbonic Anhydrase	Cardiovascular Disease Others Neurological Disease
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-N6732

K-252a Maximum Cited Publications 27 Publications Verification SF2370; Antibiotic K 252a; Antibiotic SF 2370	Autophagy PKA PKC Trk Receptor CaMK	Infection Inflammation/Immunology
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Bacterial Antibiotic CaMK	Infection Cardiovascular Disease Metabolic Disease
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-108599

DCP-LA 5+ Cited Publications FR236924	PKC CaMK Phosphatase Apoptosis	Neurological Disease
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( ²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

HY-B0109A

Dorzolamide hydrochloride 5+ Cited Publications L671152 hydrochloride; MK507 hydrochloride	Carbonic Anhydrase	Cardiovascular Disease Others
Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle *myosin-II*. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-16690

BTS 3 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Endogenous Metabolite	Metabolic Disease Cancer
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-112698

CA-5f 4 Publications Verification	p62 Atg8/LC3 Autophagy Apoptosis	Cancer
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .

HY-110243

CAIX Inhibitor S4 1 Publications Verification	Carbonic Anhydrase	Cancer
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a K_i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (K_i=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .

HY-118467

Benzolamide 2 Publications Verification CL11366	Carbonic Anhydrase	Neurological Disease Cancer
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with K_is of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a K_i of 54 nM. Benzolamide can be used for the research of glaucoma and seizures .

HY-110140

(E)-KN-93 phosphate	CaMK	Cardiovascular Disease Neurological Disease
(E)-KN-93 phosphate is a Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor with IC₅₀ values of 9 μM and 3 μM against CaMKIIδ_Monomer and CaMKIIδ_Dodecamer, respectively. (E)-KN-93 phosphate can be used in research on epilepsy, depression, and arrhythmias. .

HY-N7848

Linoleamide Linoleic acid amide	Calcium Channel	Metabolic Disease
Linoleamide is a linoleic acid amide. Linoleamide regulates Ca (II) ux and inhibits the erg current .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-W074975

CL 5343 5-Amino-1,3,4-thiadiazole-2-sulfonamide	Carbonic Anhydrase	Cancer
CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a K_i of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer .

HY-100779

Rimacalib SMP 114	CaMK Autophagy	Metabolic Disease
Rimacalib (SMP 114) is a Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC₅₀s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ .

HY-W749867

Ca(II)-EDTA disodium dihydrate CAlcium disodium EDTA dihydrate	Bacterial	Infection Others
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-B0109

Dorzolamide L671152; MK507	Carbonic Anhydrase	Cancer
Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-111014

VK-II-36	Calcium Channel	Cardiovascular Disease
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca ²⁺release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations .

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-W587805

Perfluorohexane sulfonamide FHxSA	Carbonic Anhydrase	Others
Perfluorohexane sulfonamide (FHxSA) is the inhibitor for carbonic anhydrase, that inhibits bovine CA and human CA II with IC₅₀ of 0.122 and 1.38 μM. Perfluorohexane sulfonamide is a delayed-action insecticide, that can be used to control red fire ants (Solenopsis invicta). Perfluorohexane sulfonamide could be a environmental pollutant .

HY-W013857

Lavendustin C	CaMK EGFR Src	Cancer
Lavendustin C is a potent Ca ²⁺ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC₅₀=0.012 µM) and pp60 ^c-src(+) kinase (IC₅₀=0.5 µM) .

HY-P0271A

Syntide 2 TFA 2 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Environmental Pollutants Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-146268

CaMKIIα-IN-1	CaMK	Neurological Disease
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca ²⁺/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-W170020

PTCA	CaMK	Metabolic Disease
PTCA is a potent Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) ligand with a pK_i value of 7.2 .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-152140

hCAII-IN-8	Carbonic Anhydrase	Cancer
hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.18 μM against hCA II .

HY-B0588A

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-B1471

Fluorometholone acetate 1 Publications Verification	Carbonic Anhydrase	Inflammation/Immunology
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC₅₀s of 2.18 μM and 17.5 μM for hCA-I and *hCA-II*, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research .

HY-B0124S

Zonisamide-d4	Isotope-Labeled Compounds Carbonic Anhydrase Calcium Channel Sodium Channel	Neurological Disease
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with K_is of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease .

HY-179530

CA-II/TNAP-IN-1	Carbonic Anhydrase Phosphatase	Cancer
CA-II/TNAP-IN-1 (compound 15) is a potent dual inhibitor against b-TNAP and *b-CAII* with IC₅₀s of 0.69 and 1.25 μM, respectively. CA-II/TNAP-IN-1 exhibits anti-cancer effects. CA-II/TNAP-IN-1 can be used for cancer research .

HY-32933

4-Acetylphenylboronic acid	Carbonic Anhydrase	Metabolic Disease
4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC₅₀s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II). 4-Acetylphenylboronic acid can be obtained via mechanochemistry and solvent evaporation. 4-Acetylphenylboronic acid has a loss of the carbonyl group at 500-550 K .

HY-P1479

Calmodulin-Dependent Protein Kinase II (290-309)	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II .

HY-179271

CA/HDAC-IN-1	Carbonic Anhydrase HDAC	Cancer
CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with K_i values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC₅₀ values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma .

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na ⁺ channels and N-type Ca ²⁺ channels, and is effective as a K ⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM) .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-177296

GPR40 agonist 8	Free Fatty Acid Receptor Calcium Channel	Metabolic Disease
GPR40 agonist 8 (Compound 2) is a GPR40 agonist with an EC₅₀ of 5 nM for hGPR40 Ca ²⁺. GPR40 agonist 8 can be used in the research of diseases such as Type II diabetes and obesity .

HY-129781

L-650719	Carbonic Anhydrase	Endocrinology
L-650719 is a topical carbonic anhydrase inhibitor (CAI) with a K_i of 10 nM for CA II. L-650719 has shown good intraocular pressure-lowering effects in a rabbit model. L-650719 may be used in glaucoma research .

HY-151916

Enpp/Carbonic anhydrase-IN-1	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

HY-175219

CA-II/Dkk1-IN-1	Carbonic Anhydrase	Cancer
CA-II/Dkk1-IN-1 (Compound 5d) is a dual-functional inhibitor of *CA-II* and Dkk1 with a IC₅₀ of 6.90  nM for CA-II. CA-II/Dkk1-IN-1 has significantly antioxidant activity and superior DNA binding capacity. CA-II/Dkk1-IN-1 can be used for cancers research, such as esophageal, renal, and lung cancer .

HY-B1837AR

β-Cyfluthrin (Standard) beta-Cyfluthrin (Standard)	Reference Standards Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-B0561S4

Spironolactone-d6-1	Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Cancer
Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-101136

Dealanylascamycin AT-265	Antibiotic Carbonic Anhydrase Bacterial	Infection
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with K_i values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity .

HY-W424792A

O-Desmethyl Brinzolamide hydrochloride	Carbonic Anhydrase Drug Metabolite	Neurological Disease
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a K_d of 0.136 nM for CA II and an IC₅₀ of 165 nM for CA IV .

Cat. No.	Product Name	Target	Research Area

HY-P0221

PACAP (1-38), human, ovine, rat 5 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Infection Neurological Disease
PACAP (1-38), human, ovine, rat is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P0271A

Syntide 2 TFA 2 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1479

Calmodulin-Dependent Protein Kinase II (290-309)	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P1479A

Calmodulin-Dependent Protein Kinase II(290-309) acetate	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P3811

Autocamtide-3	CaMK	Neurological Disease
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat TFA binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat TFA increases the α-secretase activity. PACAP (1-38), human, ovine, rat TFA elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat TFA can be used for neurotrophic and neuroprotective research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6732

K-252a Maximum Cited Publications 27 Publications Verification SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Autophagy PKA PKC Trk Receptor CaMK
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Cardiovascular Disease Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Rutaceae Plants Citrus Disease Research Fields Source Classification	Bacterial Antibiotic CaMK
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-N0515

Ophiopogonin D 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Polysaccharides Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer Source Classification	Endogenous Metabolite
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N7848

Linoleamide Linoleic acid amide	Microorganisms Source Classification	Calcium Channel
Linoleamide is a linoleic acid amide. Linoleamide regulates Ca (II) ux and inhibits the erg current .

HY-N0515R

Ophiopogonin D (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Steroids Source Classification	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N1228

Soyacerebroside I	Natural Products Aizoaceae Plants Source Classification	Others
Soyacerebroside I is a glycosphingolipid, together with Soyacerebroside II, which can be isolated from the seeds of Glycine max Merrill (Leguminosae). Soyacerebroside II shows ionophoretic activity for Ca ²⁺ .

HY-N8411R

Aromadendrene (Standard) (+)-Aromadendrene (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Bacterial Reference Standards
Benzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide. This product is intended for research and analytical applications. Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity .

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Histone Demethylase Endogenous Metabolite
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

Recombinant Proteins Recommended:

Carbonic Anhydrase 2 (CA-II)

Species:	Human (4) Mouse (1)
Tag:	His (5)
Source:	HEK293 (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78746

	Carbonic Anhydrase 2 Protein, Human (HEK293, His) CA2; CA-II; CAII; CAr2	Human	HEK293
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72860A

	Carbonic Anhydrase 2 Protein, Human (His) CArbonic anhydrase 2; CArbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72860

	Carbonic Anhydrase 2 Protein, Human (C-His, Solution) CArbonic anhydrase 2; CArbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-His labeled tag.

HY-P72861

	Carbonic Anhydrase 2 Protein, Mouse (HEK293, His) CArbonic anhydrase 2; CArbonic anhydrase C; CAC; CA-II; CA2	Mouse	HEK293
	Carbonic Anhydrase 2 Protein is a member of the carbonic anhydrase isozyme family, responsible for catalyzing the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. CA2 plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes. Carbonic Anhydrase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7729

	Carbonic Anhydrase 11 Protein, Human (HEK293, His) rHuCArbonic Anhydrase 11, His; CArbonic Anhydrase-Related Protein 11; CARP XI; CArbonic Anhydrase-Related Protein 2; CA-RP II; CA11; CARP2	Human	HEK293
	Carbonic Anhydrase 11 Protein, Human (HEK293, His) is an approximately 38.0 kDa carbonic anhydrase 11 protein with a His-flag. Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes.

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Cat. No.	Product Name	Chemical Structure

HY-B0124S

Zonisamide-d4
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with K_is of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease .

HY-B0561S4

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109AS

Dorzolamide-d3 hydrochloride
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109AS1

Dorzolamide-d5hydrochloride
Dorzolamide-d₅(hydrochloride) (L671152 hydrochloride-d₅) is deuterium labeled Dorzolamide (hydrochloride). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0588AS

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride . Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83617

	Carbonic Anhydrase 2 Antibody (YA3362) CA2; CArbonic anhydrase 2; CArbonate dehydratase II; CArbonic anhydrase C; CAC; CArbonic anhydrase II; CA-II	WB, IHC-P	Human, Mouse, Rat
	Carbonic Anhydrase 2 Antibody (YA3362) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Carbonic Anhydrase 2.

HY-P83617A

	Carbonic Anhydrase 2 Antibody (YA3362)(PBS only) CA2; CArbonic anhydrase 2; CArbonate dehydratase II; CArbonic anhydrase C; CAC; CArbonic anhydrase II; CA-II	WB, IHC-P	Human, Mouse, Rat
	Carbonic Anhydrase 2 Antibody (YA3362) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Carbonic Anhydrase 2.