Search Result

Results for "

CD11b+

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (4) Aminotransferases (Transaminases) (1) Antibiotic (8) Aryl Hydrocarbon Receptor (1) Autophagy (9) Bacterial (10) Caspase (1) Complement System (12) CXCR (6) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Exosomes (7) Flavivirus (1) Glucocorticoid Receptor (8) Glutaminase (1) Histone Demethylase (4) HIV (1) Integrin (7) Interleukin Related (5) Isotope-Labeled Compounds (5) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Mitophagy (8) MyD88 (1) p38 MAPK (1) PD-1/PD-L1 (1) Prostaglandin Receptor (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SARS-CoV (8) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Endocrinology (6) Infection (8) Inflammation/Immunology (20) Metabolic Disease (2) Neurological Disease (6)
Oligonucleotides:	CpG ODNs (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: CD1 CD38 CD28 CD19 CD20 CD22 Transferrin Receptor CD3 P-selectin CD6 CD2 CD276/B7-H3 CD73 c-Kit LAG-3 L-Selectin CTLA-4 CD47 ALCAM/CD166 Neprilysin E-Selectin Scavenger Receptor Class B type I (SR-BI） FLT3 Tim3 CD44 Anaplastic lymphoma kinase (ALK) CD74 Human leukocyte immunoglobulin (Ig)-like receptors (LILR) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122218

JHU-083 5+ Cited Publications	Glutaminase	Neurological Disease
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b ⁺ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals .

HY-15701B

ADH-503 2 Publications Verification (Z)-Leukadherin-1 choline	Complement System	Cancer
ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric *CD11b* agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .

HY-14648R

Dexamethasone (Standard) Maximum Cited Publications 356 Publications Verification Hexadecadrol(Standard); Prednisolone F (Standard)	Reference Standards Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payload	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-15701

Leukadherin-1 5+ Cited Publications	Integrin Complement System	Inflammation/Immunology
Leukadherin-1, a specific agonist of the leukocyte surface integrin *CD11b/CD18, increases CD11b/CD18-dependent* cell adhesion to fibrinogen with an EC₅₀ of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .

HY-W009123

Erucamide cis-13-Docosenamide	Endogenous Metabolite Bacterial	Infection Neurological Disease
Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight .

HY-120878

CXCR2-IN-2 1 Publications Verification	CXCR	Inflammation/Immunology
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC₅₀=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC₅₀ of 0.04 μM .

HY-160229

ssRNA40 sodium R-1075 sodium	Toll-like Receptor (TLR) MyD88 Caspase Reactive Oxygen Species (ROS) Autophagy Pyroptosis HIV	Infection Neurological Disease
ssRNA40 sodium (R-1075 sodium) is a single-stranded RNA40 derived from HIV-1. ssRNA40 sodium activates the TLR7, TLR8, TLR2, RIG-I, MDA5, MyD88, Caspase-3, IRE1α, NLRP3 inflammasome and IRF7 signaling pathways. ssRNA40 sodium alters mRNA expression in neutrophils, induces pro-inflammatory cytokines, ROS, autophagy (autophagy), pyroptosis (pyroptosis), neuronal death, neurodegeneration, aggregate formation and NK cell activation. ssRNA40 sodium activates the expression of CD62L, *CD11b, CD69, MX1, OAS1, ATG7, LC3B* and XBP1 in immune cell and neuronal populations. ssRNA40 sodium causes cortical neuron loss and axonal damage in mice in a TLR7-dependent manner. ssRNA40 sodium can be used in research on HIV-1 infection, neurodegeneration, COVID-19 and HIV-associated neurological disorders .

HY-14648S

Dexamethasone-d5 Hexadecadrol-d₅; Prednisolone F-d₅	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses .

HY-135750

VAF347 3 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14 ⁺CD11b ⁺ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .

HY-141677

INCB059872	Histone Demethylase	Cancer
INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 can be used for the research of myeloid leukemia .

HY-14648AR

Dexamethasone acetate (Standard) Dexamethasone 21-acetate (Standard); Hexadecadrol acetate (Standard)	Reference Standards Exosomes Glucocorticoid Receptor Autophagy Mitophagy Bacterial SARS-CoV Antibiotic Complement System ADC Payload	Inflammation/Immunology Endocrinology Cancer
Dexamethasone acetate (Standard) is the analytical standard of Dexamethasone acetate. This product is intended for research and analytical applications. Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-18263C

Elubrixin tosylate SB-656933 tosylate	CXCR Interleukin Related	Inflammation/Immunology
Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC₅₀ of 260.7 nM) and shape change (IC₅₀ of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation .

HY-P99121

*Anti-Mouse/Human CD11b* Antibody (M1/70)**	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse *CD11b* IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for researches on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer .

HY-14648S3

Dexamethasone-4,6α,21,21-d4	Isotope-Labeled Compounds Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Metabolic Disease
Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-141677A

INCB059872 dihydrochloride	Histone Demethylase	Cancer
INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 dihydrochloride can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 dihydrochloride can be used for the research of myeloid leukemia .

HY-14648S5

Dexamethasone-d3-1 Hexadecadrol-d₃-1; Prednisolone F-d₃-1	Isotope-Labeled Compounds Antibiotic Autophagy Glucocorticoid Receptor SARS-CoV ADC Payload Mitophagy Complement System Bacterial Exosomes	Cancer
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-112742

CP-195543	Leukotriene Receptor	Inflammation/Immunology
CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC₅₀s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration .

HY-125782

15(R)-15-Methyl prostaglandin D2 15(R)-15-Methyl PGD2	Prostaglandin Receptor	Metabolic Disease
15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC₅₀ values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC₅₀ for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

HY-14648S2

Dexamethasone-d4 Hexadecadrol-d₄; Prednisolone F-d₄	Isotope-Labeled Compounds Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-18263A

Elubrixin SB-656933	CXCR Interleukin Related	Inflammation/Immunology
Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC₅₀ of 260.7 nM) and shape change (IC₅₀ of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation .

HY-RS20044

Itgam Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Itgam Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itgam gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Itgam Mouse Pre-designed siRNA Set A Itgam Mouse Pre-designed siRNA Set A

HY-14648S1

Dexamethasone-d5-1 Hexadecadrol-d₅-1; Prednisolone F-d₅-1	Isotope-Labeled Compounds Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-120878A

(R,R)-CXCR2-IN-2	CXCR	Neurological Disease Inflammation/Immunology Cancer
(R,R)-CXCR2-IN-2 (compound 67), diastereoisomer of CXCR2-IN-2 (compound 68) (HY-120878), is a CXCR2 antagonist with a pIC₅₀ of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively .

HY-160018

BAY-155	Epigenetic Reader Domain	Cancer
BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC₅₀ of 8 nM. BAY-155 leads to a strong expression down-regulation of the MEIS1 gene and up-regulation of CD11b and MNDA genes. BAY-155 shows anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models .

HY-P991773

*Anti-Mouse CD11b* Antibody (5C6)**	Integrin	Inflammation/Immunology
Anti-Mouse CD11b Antibody (5C6) is a *CD11b* blocking antibody. Anti-Mouse CD11b Antibody (5C6) can be used for in vitro inhibition of myelomonocytic cell adhesion and in vivo inhibition of inflammatory cell recruitment. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682) .

HY-W744577

Dexamethasone acetate-d5 Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅	Isotope-Labeled Compounds Glucocorticoid Receptor ADC Payload Bacterial Autophagy SARS-CoV Complement System Mitophagy Antibiotic Exosomes	Inflammation/Immunology Endocrinology Cancer
Dexamethasone acetate-d₅ (Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-P991836

*Anti-CD11b* Antibody (ICRF44)**	Integrin	Inflammation/Immunology
Anti-CD11b Antibody (ICRF44) reacts with the human CD11b. Anti-CD11b Antibody (ICRF44) recognizes the α subunit of the CD11b/CD18 complex, an α/β heterodimeric surface glycoprotein on human leukocytes. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-15701R

Leukadherin-1 (Standard)	Integrin Complement System	Inflammation/Immunology
Leukadherin-1 (Standard) is the analytical standard of Leukadherin-1. This product is intended for research and analytical applications. Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .

HY-15701A

(Z)-Leukadherin-1 2 Publications Verification ADH-503 free base	Complement System	Cancer
(Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric *CD11b* agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .

HY-18263

Elubrixin hydrochloride SB-656933 hydrochloride	CXCR Interleukin Related	Inflammation/Immunology
Elubrixin (SB-656933) hydrochloride is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin hydrochloride inhibits neutrophil CD11b upregulation (IC₅₀ of 260.7 nM) and shape change (IC₅₀ of 310.5 nM). Elubrixin hydrochloride has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation .

HY-141677B

INCB059872 tosylate	Histone Demethylase	Cancer
INCB059872 tosylate is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 tosylate can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 tosylate can be used for the research of myeloid leukemia .

HY-P991791

*Anti-Rat CD11b/c Antibody (OX42)*	Integrin	Neurological Disease
Anti-Rat CD11b/c Antibody (OX42) reacts with rat CD11b and CD11c. Anti-Rat CD11b/c Antibody (OX42) inhibits complement-mediated rosettes formation and leukocyte migration in vitro, and blocks the binding of iC3b to CR3 in vitro and in vivo. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-18263CR

Elubrixin tosylate (Standard) SB-656933 tosylate (Standard)	CXCR Interleukin Related Reference Standards	Inflammation/Immunology
Elubrixin (tosylate) (Standard) is the analytical standard of Elubrixin (tosylate). This product is intended for research and analytical applications. Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation .

HY-169067

10-Methoxy-canthin-6-one Mtx-C	DNA/RNA Synthesis p38 MAPK Bacterial	Infection Cancer
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML) .

HY-RS06960

ITGAM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ITGAM Human Pre-designed siRNA Set A contains three designed siRNAs for ITGAM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ITGAM Human Pre-designed siRNA Set A ITGAM Human Pre-designed siRNA Set A

HY-P992314

ASD141	Integrin PD-1/PD-L1	Cancer
ASD141 is a mouse IgG1 antibody targeting mouse *CD11b* and a CD11b antagonist. ASD141 remodels the tumor microenvironment, enhances antigen presentation ability, and induces PD-L1 expression. ASD141 can be used for the research of colon cancer .

HY-116509

Linoleylanilide Linoleic acid anilide; LAA	Drug Derivative Lactate Dehydrogenase Aminotransferases (Transaminases)	Cardiovascular Disease
Linoleylanilide (Linoleic acid anilide) is a Linoleic acid (HY-N0729) derivative. Linoleylanilide slightly inhibits the PMA (HY-18739)-induced expression of *CD11b. Linoleylanilide inhibits serum LDH, GOT* and GPT activities. Linoleylanilide decreases red cell counts and hemoglobin content .

HY-141677C

INCB059872 TFA	Histone Demethylase	Cancer
INCB059872 TFA is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 TFA can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 TFA can be used for the research of myeloid leukemia .

HY-P991772

Anti-WNV E protein DIII-LR Antibody (E16)	Flavivirus	Infection
Anti-WNV E protein DIII-LR Antibody (E16) reacts with the domain III lateral ridge (DIII-LR) of the envelope (E) protein of West Nile Virus (WNV). Anti-Mouse CD11b Antibody (5C6) protects mice from WNV infection. Recommend Isotype Controls: Mouse IgG2b kappa, Isotype Control (HY-P99982) .

HY-RS26547

Itgam Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Itgam Rat Pre-designed siRNA Set A contains three designed siRNAs for Itgam gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Itgam Rat Pre-designed siRNA Set A Itgam Rat Pre-designed siRNA Set A

HY-P992382

IC 100	Interleukin Related	Neurological Disease Inflammation/Immunology
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99121

*Anti-Mouse/Human CD11b* Antibody (M1/70)**	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse *CD11b* IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for researches on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer .

HY-P991773

*Anti-Mouse CD11b* Antibody (5C6)**	Integrin	Inflammation/Immunology
Anti-Mouse CD11b Antibody (5C6) is a *CD11b* blocking antibody. Anti-Mouse CD11b Antibody (5C6) can be used for in vitro inhibition of myelomonocytic cell adhesion and in vivo inhibition of inflammatory cell recruitment. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682) .

HY-P991836

*Anti-CD11b* Antibody (ICRF44)**	Integrin	Inflammation/Immunology
Anti-CD11b Antibody (ICRF44) reacts with the human CD11b. Anti-CD11b Antibody (ICRF44) recognizes the α subunit of the CD11b/CD18 complex, an α/β heterodimeric surface glycoprotein on human leukocytes. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-P991791

*Anti-Rat CD11b/c Antibody (OX42)*	Integrin	Neurological Disease
Anti-Rat CD11b/c Antibody (OX42) reacts with rat CD11b and CD11c. Anti-Rat CD11b/c Antibody (OX42) inhibits complement-mediated rosettes formation and leukocyte migration in vitro, and blocks the binding of iC3b to CR3 in vitro and in vivo. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P992314

ASD141	Integrin PD-1/PD-L1	Cancer
ASD141 is a mouse IgG1 antibody targeting mouse *CD11b* and a CD11b antagonist. ASD141 remodels the tumor microenvironment, enhances antigen presentation ability, and induces PD-L1 expression. ASD141 can be used for the research of colon cancer .

HY-P991772

Anti-WNV E protein DIII-LR Antibody (E16)	Flavivirus	Infection
Anti-WNV E protein DIII-LR Antibody (E16) reacts with the domain III lateral ridge (DIII-LR) of the envelope (E) protein of West Nile Virus (WNV). Anti-Mouse CD11b Antibody (5C6) protects mice from WNV infection. Recommend Isotype Controls: Mouse IgG2b kappa, Isotype Control (HY-P99982) .

HY-P992382

IC 100	Interleukin Related	Neurological Disease Inflammation/Immunology
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .

Cat. No.	Product Name	Chemical Structure

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses .

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-W744577

Dexamethasone acetate-d5

Dexamethasone acetate-d₅ (Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Host:	Rat (1) Mouse (2) Rabbit (4)
Reactivity:	Human (4) Rat (1) Mouse (4)
Application:	IHC-P (4) ICC/IF (4) IP (4) WB (4) FC (4) ELISA (3)
Isotype:	IgG (4) IgG1 (2) IgG2b (1)
Conjugation:	APC (1) Non-conjugated (7)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84054

	CD11b Antibody (YA3751) CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6	IHC-P, ICC/IF, FC, ELISA	Human
	CD11b Antibody (YA3751) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD11b.

HY-P84054A

	CD11b Antibody (YA3751)(PBS only) CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6	IHC-P, ICC/IF, FC, ELISA	Human
	CD11b Antibody (YA3751) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD11b.

HY-P810308-APC

	CD11b Antibody (APC) (YA9641)	FC	Mouse

HY-P80592

	CD11b Antibody (YA546) CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1	WB, IP	Mouse
	CD11b Antibody (YA546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P83690

	CD11b Antibody (YA3423) CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1	WB, IHC-P, ICC/IF, IP, FC	Human
	CD11b Antibody (YA3423) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P80592A

	CD11b Antibody (YA546)(PBS only) CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1	WB, IP	Mouse
	CD11b Antibody (YA546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P86309

	CD11b Antibody (YA6001) Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD11b Antibody (YA6001) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P84956

	CD11b Antibody (YA4648) Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b;
	CD11b Antibody (YA4648) is a non-conjugated antibody, targeting to CD11b.

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Cat. No.	Product Name		Classification

HY-160229

ssRNA40 sodium R-1075 sodium		CpG ODNs
ssRNA40 sodium (R-1075 sodium) is a single-stranded RNA40 derived from HIV-1. ssRNA40 sodium activates the TLR7, TLR8, TLR2, RIG-I, MDA5, MyD88, Caspase-3, IRE1α, NLRP3 inflammasome and IRF7 signaling pathways. ssRNA40 sodium alters mRNA expression in neutrophils, induces pro-inflammatory cytokines, ROS, autophagy (autophagy), pyroptosis (pyroptosis), neuronal death, neurodegeneration, aggregate formation and NK cell activation. ssRNA40 sodium activates the expression of CD62L, *CD11b, CD69, MX1, OAS1, ATG7, LC3B* and XBP1 in immune cell and neuronal populations. ssRNA40 sodium causes cortical neuron loss and axonal damage in mice in a TLR7-dependent manner. ssRNA40 sodium can be used in research on HIV-1 infection, neurodegeneration, COVID-19 and HIV-associated neurological disorders .

HY-RS20044

Itgam Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Itgam Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itgam gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06960

ITGAM Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ITGAM Human Pre-designed siRNA Set A contains three designed siRNAs for ITGAM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26547

Itgam Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Itgam Rat Pre-designed siRNA Set A contains three designed siRNAs for Itgam gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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