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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15063 Results for "
Comparative receptor surface analysis
" in MedChemExpress (MCE) Product Catalog:
Products (15063)
15063 Results for "Comparative receptor surface analysis" in MCE Product Catalog:
170
170 Publications Verification
Cat. No.: HY-17366
CAS No.: 34233-69-7
Target:
Research Areas:
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
170
170 Publications Verification
Cat. No.: HY-17366A
CAS No.: 2250025-93-3
Target:
Research Areas:
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
150
150 Cited Publications
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
143
143 Cited Publications
Target:
Research Areas:
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
80
80 Cited Publications
Synonyms: RU486; RU 38486
Research Areas:
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay .
79
79 Cited Publications
Synonyms: Levarterenol; L-Noradrenaline
79
79 Cited Publications
Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride
79
79 Cited Publications
Synonyms: Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate
79
79 Cited Publications
Synonyms: Levarterenol tartrate; L-Noradrenaline tartrate
79
79 Cited Publications
Synonyms: 1,25-Dihydroxyvitamin D3
77
77 Cited Publications
Synonyms: GS 4071 hydrochloride; Ro 64-0802 hydrochloride; Oseltamivir carboxylate hydrochloride
Target:
Research Areas:
Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis .
66
66 Cited Publications
Target:
Research Areas:
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
65
65 Cited Publications
Synonyms: Repertaxin L-lysine salt
Target:
Research Areas:
Reparixin L-lysine salt is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.
61
61 Cited Publications
Synonyms: Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone
60
Target:
Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
54
54 Cited Publications
Synonyms: MC 903; Calcipotriene
Target:
Research Areas:
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
54
54 Cited Publications
Target:
Research Areas:
Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
53
Target:
Research Areas:
Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM, respectively .
52
Research Areas:
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
51
51 Cited Publications
Target:
Research Areas:
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
