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DC

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By Research Areas:	Cancer (713) Cardiovascular Disease (16) Endocrinology (5) Infection (45) Inflammation/Immunology (111) Metabolic Disease (30) Neurological Disease (25)
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932

Inhibitors & Agonists

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Inhibitory Antibodies

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15594A

Phen-DC3 Trifluoromethanesulfonate 5+ Cited Publications Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-177129

Simepdekinra LY4100511; DC-853	Interleukin Related	Inflammation/Immunology
Simepdekinra (LY4100511; DC-853) is an IL-17A antagonist. Simepdekinra can be used in the research of moderate to severe plaque-type psoriasis .

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Amyloid-β Liposome IFNAR Interleukin Related	Neurological Disease Inflammation/Immunology
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-154919

DC-Y13-27 4 Publications Verification	YTHDF FOXO MMP Pyroptosis Interleukin Related	Endocrinology Cancer
DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (K_D: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .

HY-111621

DC661 5+ Cited Publications	Autophagy Apoptosis	Cancer
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity .

HY-45491

Dmt-2'-f-dc(ac) amidite 2'-F-Ac-DC Phosphoramidite; DMT-2′Fluoro-DC(ac) Phosphoramidite	Phosphoramidites Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides .

HY-101906

DC260126 3 Publications Verification	Free Fatty Acid Receptor Apoptosis	Metabolic Disease
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca ²⁺ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively) . DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .

HY-150505

DC-U4106 1 Publications Verification	Deubiquitinase Apoptosis	Cancer
DC-U4106 is a USP8 targeting inhibitor with the K_dvalue of 4.7 μM and the IC₅₀ value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer .

HY-148488

A18-Iso5-2DC18	Liposome STING	Inflammation/Immunology Cancer
A18-Iso5-2DC18 (Compound A18) is a cyclic lipidoid. A18-Iso5-2DC18 partially activates STING. A18-Iso5-2DC18 promotes mRNA protein expression and induces a strong immune response. A18-Iso5-2DC18 can be used in melanoma research .

HY-138577

2'-F-Bz-dC Phosphoramidite	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Cancer
2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells .

HY-107636

DC_AC50 5+ Cited Publications	Apoptosis	Cancer
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .

HY-153780

Navepdekinra DC-806; LY4100504; S-011806	Interleukin Related	Inflammation/Immunology
Navepdekinra (DC-806) is an orally active, potent interleukin-17A (IL-17A) inhibitor (IC₅₀ = 10.81 nM). Navepdekinra disrupts the IL-17A protein-receptor interaction, suppressing the downstream pro-inflammatory signaling pathway. Navepdekinra inhibits arthritis in a collage-induced arthritis (CIA) rat model. Navepdekinra can be used for psoriasis, psoriatic arthritis, and ankylosing spondylitis .

HY-12746

DC-05 1 Publications Verification	DNA Methyltransferase	Cancer
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.

HY-151509

A2-Iso5-2DC18	Liposome	Cancer
A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma. .

HY-12747

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-153469

Benzyl DC-81	ADC Payload	Cancer
Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells .

HY-147868

DC-CPin711	Epigenetic Reader Domain Apoptosis	Cancer
DC-CPin711 is a potent and selective inhibitor of CREB-binding protein (CBP) bromodomain with an IC₅₀ of 0.0626 μM. DC-CPin711 arrests cell cycle at G1 phase and induces apoptosis .

HY-W008849

DMT-dC(bz) Phosphoramidite	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
DMT-dC (bz) Phosphoramidite is a protected deoxycytidine phosphoramidite monomer, as well as a building block for mechanochemical DNA synthesis. DMT-dC (bz) Phosphoramidite serves as a reagent for oligonucleotide synthesis .

HY-141882

DC-LC3in-D5 1 Publications Verification	Atg8/LC3 Autophagy	Infection Inflammation/Immunology Cancer
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC₅₀ of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy .

HY-138586

DMT-dC(ac) Phosphoramidite 1 Publications Verification	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Cancer
DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis .

HY-43643

DC-5163 1 Publications Verification	Apoptosis	Cancer
DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC₅₀ of 176.3 nM and a K_d of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis .

HY-163794

DC371739	ANGPTL PCSK9	Metabolic Disease
DC371739 is a potent and orally activity PCSK9 inhibitor. DC371739 decreases the mRNA expression of PCSK9 and ANGPTL3. DC371739 decreases the protein expression of PCSK9 and increases the protein expression of LDLR. DC371739 has the potential for the research of hyperlipidemia .

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity .

HY-160477

DC-SX029	PIKfyve NF-κB IKK	Inflammation/Immunology
DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated K_D constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research .

HY-123517

DC07090 dihydrochloride	Enterovirus	Infection
DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC₅₀ and a K_i value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC₅₀ value of 27.76 μM .

HY-178861

dCDK9-202	PROTACs CDK Caspase PARP Apoptosis	Cancer
dCDK9-202 a potent CDK9 PROTAC degrader with an *DC₅₀* value of 3.5 nM. dCDK9-202 exhibits broad-spectrum anti-tumor activity and extensively disrupts the oncogenic transcriptome. dCDK9-202 can activate Caspase-3/7, increase the level of cleaved PARP, and directly induce apoptosis of tumor cells. dCDK9-202 effectively inhibits TC-71 tumor growth without any signs of toxicity in mice. dCDK9-202 can be used for the study of EGFR-driven cancers such as sarcoma (Pink: CDK9 ligand (HY-178862); Blue: CRBN ligand (HY-W248665); Black: Linker (HY-N8015)) .

HY-107767

Antibiotic DC 81 DC 81	Antibiotic Apoptosis DNA/RNA Synthesis	Cancer
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .

HY-126621

DC-TEADin02	YAP	Cancer
DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC₅₀ value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis .

HY-116893

Diethyl bipy55'DC	HIF/HIF Prolyl-Hydroxylase MOFs	Cancer
Diethyl bipy55'DC is an inhibitor of collagen proline 4-hydroxylases (CP4Hs) with antifibrotic and anti-metastatic activities. Diethyl bipy55'DC can inhibit CP4H activity in cultured cells at concentrations that do not cause iron deficiency .

HY-120937

DC4 Crosslinker	Biochemical Assay Reagents	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-141703A

DC-BPi-11 hydrochloride	Epigenetic Reader Domain	Cancer
DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC₅₀ value of 698 nM. DC-BPi-11 hydrochloride shows remarkable inhibition against leukemia cell proliferation .

HY-D1190

DC271	RAR/RXR	Others
DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm) .

HY-141703

DC-BPi-11	Epigenetic Reader Domain	Cancer
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC₅₀ value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation .

HY-151511

A12-Iso5-2DC18	Liposome	Cancer
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .

HY-129379

DC0-NH2	ADC Payload	Cancer
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component .

HY-135125

DC4	ADC Payload	Cancer
DC4, an ADC cytotoxin, can be used in the synthesis of antibody-drug conjugate (ADC). DC4 can be used for the targeted treatment of cancer .

HY-112899

DC1	ADC Payload DNA Alkylator/Crosslinker	Cancer
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

HY-112898

DC1SMe	ADC Payload	Cancer
DC1Sme, a DC1 derivative, exhibits IC₅₀ values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

HY-151512

A12-Iso5-4DC19	Liposome	Inflammation/Immunology Cancer
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .

HY-P990398

Anti-DC-SIGN/CD209 Antibody	Integrin	Inflammation/Immunology
Anti-DC-SIGN/CD209 Antibody is a CHO-expressed humanized antibody that targets *DC-SIGN/CD209*. Anti-DC-SIGN/CD209 Antibody is composed of huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 146.62 kDa. The isotype control for Anti-DC-SIGN/CD209 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-150211

DC-BPi-03	Epigenetic Reader Domain	Cancer
DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC₅₀ of 698.3 nM and a K_d of 2.81 μM .

HY-P99892

Serclutamab PR-1594407; DC-1630423	EGFR	Others
Serclutamab is a humanized chimeric antibody targeting EGFR IgG1-κ. Mainly expressed by CHO (Chinese Hamster Ovary) cells .

HY-129427

DC-015	Adrenergic Receptor	Cardiovascular Disease
DC-015 is a selective and orally active alpha 1-adrenoceptor antagonist on plasma lipid and vascular reactivity in hyperlipidaemic rodent model. DC-015 is a synthesized quinazoline derivative. DC-015 decreases mean arterial pressure in rats. DC-015 has antihypertensive activity .

HY-106998

DC-756	Bacterial Antibiotic	Infection
DC-756 is a fluoroquinolone antibiotic. DC-756 possesses potent activity against Gram-positive and Gram-negative pathogens comparable to Trovafloxacin (HY-A0170), with MIC, against Ofloxacin (HY-B0125)-resistant strains 16-fold better than Trovafloxacin. DC-756 is well absorbed orally in rats and found to have good photostability. DC-756 can be used to study bacterial resistance .

HY-112901

DC41	ADC Payload	Cancer
DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer .

HY-159955

DC-159a	Bacterial	Infection
DC-159a is an 8-methoxyfluoroquinolone with broad-spectrum antimicrobial activity, especially against Gram-positive pathogens. DC-159a against Peptostreptococcus, Clostridium difficile, and Bacteroides fragilis with MIC₉₀ values of 0.5, 4, and 2 μg/mL, respectively .

HY-W800782

DC-6-14	Liposome	Others
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes .

HY-169863

DC360	RAR/RXR	Inflammation/Immunology
DC360 is a synthetic retinoid analogue of all-trans retinoic acid (ATRA) which induces RARβ expression. DC360 can be utilized in characterization of retinoid signalling pathways .

HY-112900

DC41SMe	ADC Payload	Cancer
DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC₅₀s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer .

HY-177944

DC-PGKI	Phosphoglycerate Kinase (PGK) Keap1-Nrf2 Interleukin Related	Inflammation/Immunology
DC-PGKI is an orally active ATP-competitive PGK1 inhibitor(IC₅₀ = 0.16 Μm, K_d = 99.08 nM). DC-PGKI stabilizes PGK1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. DC-PGKI-mediated inhibition of PGK1 leads to the accumulation of NRF2 (nuclear factor-erythroid factor 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and suppresses the LPS-induced expression of these genes. DC-PGKI can be used for the study of colitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0154

Neohesperidin dihydrochalcone 4 Publications Verification Neohesperidin DC; NHDC	Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Dihydrochalcones Inflammation/Immunology Disease Research Fields Sweeteners Source Classification Food Research	Reactive Oxygen Species (ROS)
Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

HY-N0498

Nitidine chloride 4 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N0119

Naringin Dihydrochalcone 4 Publications Verification Naringin DC	Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Sweeteners Source Classification Cancer Food Research	NF-κB
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-N2120

Dichotomitin 1 Publications Verification	Flavonoids Iridaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Source Classification	Others
Dichotomitin is an isoflavonoid isolated from the rhizomes of Belamcanda chinensis (L.) DC .

HY-N4258

Panasenoside	Panax ginseng C. A. Meyer Flavonols Classification of Application Fields Metabolic Disease Plants Lilium pumilum DC. Flavonoids Liliaceae Phenols Polyphenols Disease Research Fields Araliaceae Source Classification	Glycosidase
Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits α-glucosidase inhibitory activity .

HY-N2358

Blumeatin	Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Plants Acacia confusa Merr. Compositae Disease Research Fields Inflammation/Immunology Source Classification	Others
Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

HY-N10886

Eupatolitin Eupatoletin	Flavonols Flavonoids Centaurea aspera stenophylla Plants Umbelliferae Source Classification	Others
Eupatoletin is a flavonol compound isolated from Eupatorium ligustrinum D.C. .

HY-130801

5-Hydroxy-2'-deoxyuridine 5-OHdU	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

HY-N7665

Prosaikogenin G	Triterpenes Classification of Application Fields Terpenoids Metabolic Disease Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Others
Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .

HY-113042

Prostaglandin B2	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite
Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw .

HY-N8922

Platycodin A	Triterpenes Classification of Application Fields Terpenoids Campanulaceae Other Diseases Plants Disease Research Fields Source Classification	Others
Platycodin A is monoacetylated saponin compound isolated fromhe roots of Platycodon grandiflorum A. DC. .

HY-N0057A

(E)-3,4-Dicaffeoylquinic acid (E)-3,4-Di-O-caffeoylquinic acid; (E)-Isochlorogenic acid B	Structural Classification Caprifoliaceae Lonicera japonica Thunb. Phenols Polyphenols Plants Source Classification	Others
(E)-3,4-Dicaffeoylquinic acid ((E)-3,4-Di-O-caffeoylquinic acid) (compound 4) is a compound that can be isolated from the aerial part of Baccharis dracunculifolia DC .

HY-N17338

Nupharamine (-)-Nupharamine	Structural Classification Alkaloids Other Alkaloids Nuphar japonica DC. Plants Nymphaeaceae Source Classification	Others
Nupharamine ((-)-Nupharamine) is an alkaloid. Nupharamine can be isolated from the root of Nuphar japonicum DC .

HY-N4215

11(α)-Methoxysaikosaponin F	Triterpenes Classification of Application Fields Terpenoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC₅₀ of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity .

HY-130596

DC-86-M	Microorganisms Antibiotics Disease Research Anticancer Source Classification	Antibiotic Bacterial
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-117818

Sapurimycin Antibiotic DC 116	Microorganisms Antibiotics Disease Research Anticancer Source Classification	Antibiotic
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .

HY-N0119R

Naringin Dihydrochalcone (Standard) Naringin DC (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Dihydrochalcones Source Classification	Reference Standards NF-κB
Naringin Dihydrochalcone (Standard) is the analytical standard of Naringin Dihydrochalcone. This product is intended for research and analytical applications. Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-N0154R

Neohesperidin dihydrochalcone (Standard) Neohesperidin DC (Standard); NHDC (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Dihydrochalcones Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Neohesperidin dihydrochalcone (Standard) is the analytical standard of Neohesperidin dihydrochalcone. This product is intended for research and analytical applications. Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

HY-N11032

Menisporphine	Alkaloids Plants Isoquinoline Alkaloids Menispermaceae Menispermum dauricum Source Classification	Others
Menisporphine is an alkaloid that can be found in Menisperum dauricum DC .

HY-N11029

Dauriporphine	Alkaloids Plants Isoquinoline Alkaloids Menispermaceae Menispermum dauricum Source Classification	Others
Dauriporphine, an alkaloid, can be isolated from the vines of Menispermum dauricum DC .

HY-N8999

Thalrugosidine	Alkaloids Ranunculaceae Pyridine Alkaloids Plants Source Classification Thalictrum foliolosum DC.	Others
Thalrugosidine is a Alkaloids product that can be isolated from the roots of Thalictrum foliolosum DC. .

HY-N1303

Shoreic acid Shoric acid	Ketones, Aldehydes, Acids Cabralea eichleriana DC. Plants Meliaceae Source Classification	Others
Shoreic acid (compound 8a) is a dammarane skeleton compound isolated from Cabralea eichleriana DC .

HY-N3309

Mearnsitrin	Myrcia multiflora (Lam.) DC. Flavonols Flavonoids Phenols Polyphenols Myrtaceae Plants Source Classification	Others
Mearnsitrin (compound 8) is a flavonol that can be isolated from methanolic extract Myrcia multiflora DC .

HY-N12499

Eupalitin	Flavonols Flavonoids Melilotus albus Desr. Plants Compositae Source Classification	Others
Eupalitin, flavonol, is an active natural product. Eupalitin can be isolated from Eupatorium ligustrinum D.C .

HY-N8379

Morolic acid	Triterpenes Phoradendron brachystachyum (DC.) Nutt. Ketones, Aldehydes, Acids Terpenoids Plants Source Classification Santalaceae	Others
Morolic acid (compound 6) can be isolated from Phoradendron brachystachyum DC Nutt. Morolic acid has antiretroviral activity .

HY-N8828

6''-O-Acetylsaikosaponin D	Triterpenes Terpenoids Umbelliferae Plants Ambrosia arborescens Mill. Source Classification	Others
6''-O-Acetylsaikosaponin D is a Triterpenoids product that can be isolated from the herbs of Bupleurum chinense DC. .

HY-N8766

Dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside	Lignans Phenylpropanoids Umbelliferae Plants Leontopodium brachyactisGand. Source Classification	Others
Dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside is a Lignans product that can be isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov. .

HY-N3804

enantio-7(11)-Eudesmen-4-ol	Crotalaria sessiliflora L. Terpenoids Sesquiterpenes Plants Compositae Source Classification	Others
enantio-7(11)-Eudesmen-4-ol is a Sesquiterpenoids product that can be isolated from the herbs of Laggera pterodonta (DC.) Benth. .

HY-N3017R

Artemitin (Standard)	Flavonols Structural Classification Monophenols Flavonoids other families Phenols Plants Source Classification	Antibiotic Reference Standards
Artemitin (Standard) is the analytical standard of Artemitin. This product is intended for research and analytical applications. Artemitin is a flavonol found in Laggera pterodonta (DC.) Benth., with antioxidative, anti-inflammatory, and antiviral activity .

HY-N8508

Myrothecine A	Natural Products Microorganisms Source Classification	Apoptosis Cytochrome P450 PARP JNK Bcl-2 Family Caspase
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC₅₀s of 95, 70, 60, and 25 µM, respectively .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Source Classification	Reference Standards Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N11507

Tibesaikosaponin V TKV	Triterpenes Sonchus asper (L.) Hill Terpenoids Plants Umbelliferae Source Classification	PPAR
Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Terpenoids Celastraceae Diterpenoids Celastrus Plants Source Classification	Others
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-N18099

Bianfugedine	Structural Classification Alkaloids Quinoline Alkaloids Plants Menispermaceae Menispermum dauricum Source Classification	Others
Bianfugedine is an alkaloid found in the dried rhizomes of Menispermum dauricum DC .

HY-N11242

Cascaroside C	Quinones Structural Classification Rheum australe D. Don Anthraquinones Polygonaceae Plants Source Classification	Drug Derivative
Cascaroside C is an anthraquinone compound. Cascaroside C can be isolated from the roots of Rheum emodi and Rhamnus purshianus DC .

HY-107196

Gancaonin P	Structural Classification Flavonols Flavonoids Leguminosae Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
Gancaonin P (Compound 5) is a prenylated flavonoid found in the aerial parts of Glycyrrhiza uralensis FISCH. et DC .

HY-N18289

8-Hydroxydihydrochelerythrine	Structural Classification Alkaloids Other Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Source Classification	Cholinesterase (ChE)
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC₅₀=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease .

HY-N8603

Desacetyldoronine	Alkaloids Other Alkaloids Plants Compositae Butea monosperma Kuntze Source Classification	Others
Desacetyldoronine is a Alkaloids product that can be isolated from the herbs of Emilia sonchifolia (L.) DC. .

HY-N8794

Rhapontisterone B	Cardiacglycosides Rhaponticum uniflorum (L.) DC. Asteraceae Plants Steroids Source Classification	Others
Rhapontisterone B is a Steroids product that can be isolated from the herbs of Rhaponticum uniflorum (L.) DC. .

HY-N1325

Sanshodiol	Zanthoxylum bungeanum Maxim. Lignans Rutaceae Phenylpropanoids Plants Source Classification	Others
Sanshodiol is a Lignans product that can be isolated from the stem barks of Xanthoxylum piperitum DC. .

HY-N1769

3,4-Diacetoxycinnamamide	Berberis thunbergii DC. Simple Phenylpropanols Phenylpropanoids Plants Berberidaceae Source Classification	Others
3,4-Diacetoxycinnamamide is a Phenylpropanoids product that can be isolated from the herbs of Berberis thunbergii DC. .

HY-N18092

Platycodin C	Structural Classification Natural Products Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Source Classification	Others
Platycodin C is an oleanane-type oligoglycoside and monoacetylated saponin found in the roots of Platycodon grandiflorum A. DC. (Campanulaceae) .

HY-W540176

2,6-Dimethyloctane	Structural Classification Natural Products Cymbopogon citratus Gramineae Plants Source Classification	Others
2,6-Dimethyloctane is a type of straight-chain alkanoid volatile component isolated and identified from the essential oil of lemon grass (Cymbopogon citratus (DC) Stapf) leaves .

HY-N15170

Neochrome	Structural Classification Natural Products Malpighiaceae Malpighia emarginata DC. Plants Source Classification	Drug Derivative
Neochrome, 5,8-epoxide derivative, is a Carotenoid. Neochrome is a chimeric photoreceptor between phytochrome and phototropin. Neochrome can be extracted from the fruit of Malpighia emarginata DC. syn. Malpighia glabra L. Neochrome can be found in some advanced ferns and in the green alga M. scalaris. Neochrome can serve as the red light receptor for chloroplast movement in ferns and green algae .

HY-114341

Kaempferol 5-glucoside Kaempferol 5-O-β-D-glucopyranoside	Structural Classification Flavonols Flavonoids Plants Indigofera aspalathoides Vahl ex DC. Fabaceae Source Classification	Others
Kaempferol 5-glucoside (Kaempferol 5-O-β-D-glucopyranoside) is an orally active flavonol glycoside and immunomodulator. Kaempferol 5-glucoside is isolated from the aerial parts of Indigofera aspalathoides Vahl ex DC. Kaempferol 5-glucoside enhances delayed-type hypersensitivity in rats. Kaempferol 5-glucoside increases humoral antibody titers. Kaempferol 5-glucoside is used for the research of autoimmune diseases .

HY-N15435

Conimine	Apocynaceae Structural Classification Alkaloids Other Alkaloids Plants Holarrhena antidysenterica Roth Source Classification	Bacterial
Conimine is a steroidal alkaloid, antibacterial agent and potentiator. Conimine is isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Conimine exhibits intrinsic antibacterial activity against methicillin-sensitive *Staphylococcus aureus* and methicillin-resistant *Staphylococcus aureus. When combined with Penicillin, Conimine shows synergistic antibacterial effects against methicillin-resistant Staphylococcus aureus; when combined with Vancomycin (HY-B0671), it exerts synergistic antibacterial effects against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus* .

HY-N14094

Tubulosine	Structural Classification Alkaloids Other Alkaloids Rubiaceae Plants Pogonopus tubulosus (A.Rich. ex DC.) K.Schum. Source Classification	JAK Apoptosis Autophagy
Tubulosine is an alkaloid. Tubulosine can be isolated from Pogonopus tubulosus (DC.) Schumann. Tubulosine is an ATP-competitive, selective JAK3 inhibitor with an IC₅₀ value of 9.9 nM. Tubulosine also inhibits the kinase activities of other JAK family members, the extent of inhibition is less than that of JAK3, with IC₅₀ values of 69.5, 84.9 and 76.3 nM for JAK1, JAK2 and TYK2, respectively. Tubulosine selectively inhibits JAK3 signalling by binding to the ATP-binding site of the kinase of JAK3. Tubulosine induces apoptotic and necrotic/autophagic cell death. Tubulosine inhibits the process of peptide chain elongation by eukaryotic polysomes by, specifically preventing the elongation-factor-2-dependent step of translocation. Tubulosine exhibits anticancer activity in breast cancer cells .

Cat. No.	Product Name	Chemical Structure

HY-138642S

Vepdegestrant-d5

Vepdegestrant-d₅ (ARV-471-d₅) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC₅₀ of about 2 nM .

HY-N0154S

Neohesperidin Dihydrochalcone-d3
Neohesperidin Dihydrochalcone-d₃ (Neohesperidin DC-d₃; NHDC-d₃) is the deuterium labeled Neohesperidin dihydrochalcone (HY-N0154). Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

HY-W750212

Acid Orange 7-13C6

Acid Orange 7- ¹³C₆ (Orange II- ¹³C₆) is the ¹³C-labeled Acid orange 7 (HY-N1442). Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. It is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .

HY-138586S

DMT-dC(ac) Phosphoramidite-13C9, 15N3
DMT-dC(ac) Phosphoramidite- ¹³C₉, ¹⁵N₃ is the ¹³C- and ¹⁵N-labeled DMT-dC(ac) Phosphoramidite (HY-138586). DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis .

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