DLL4

By Targets:	Akt (1) Amyloid-β (1) Apoptosis (1) ATM/ATR (1) Cholinesterase (ChE) (1) Ferroptosis (1) FGFR (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (2) Interleukin Related (1) mTOR (1) NF-κB (2) NO Synthase (1) Notch (7) PTEN (1) Small Interfering RNA (siRNA) (3) VEGFR (4) γ-secretase (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99377

Navicixizumab OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)	Notch	Cancer
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .

HY-P99261

Demcizumab OMP 21M18	Notch	Cancer
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models .

HY-P99852

Dilpacimab ABT165; PR1283233	VEGFR Notch	Cancer
Dilpacimab (ABT165) is a bispecific variable domain immunoglobulin. Dilpacimab binds to and inhibits *DLL4* and VEGF and acts as a tumor growth inhibitor. Dilpacimab can be used in research related to metastatic colorectal cancer and advanced solid tumors .

HY-P99925

Enoticumab REGN421	Notch	Metabolic Disease Cancer
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human *Dll4. DLL4* is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .

HY-122094

Steppogenin	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Cancer
Steppogenin is a potent inhibitor of HIF-1α and *DLL4, with IC₅₀* values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors .

HY-P991033

Tovecimig CTX-009	VEGFR	Inflammation/Immunology
HY-P991033 is an *VEGFA/DLL4*-targeting G1-scFvlh_L-κ type bispecific antibody .

HY-P991423

MEDI0639 21H3RK	Notch	Cancer
MEDI0639 (21H3RK) is a human monoclonal antibody (mAb) targeting *DLL4. MEDI0639 inhibits Notch1* binding to Dll4. MEDI0639 reverses Notch1-mediated growth inhibition of human umbilical vein endothelial cells in vitro. MEDI0639 promotes human angiogenesis and reduces the number of vessels covered by smooth muscle actin-positive mural cells. MEDI0639 can be used in Small cell lung cancer and solid tumors research .

HY-N11709

Theasaponin E1	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal	Infection Neurological Disease Metabolic Disease Cancer
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and *4E-BP1* proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands *Dll4* and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections ^[4] .

HY-RS03810

DLL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DLL4 Human Pre-designed siRNA Set A contains three designed siRNAs for DLL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DLL4 Human Pre-designed siRNA Set A DLL4 Human Pre-designed siRNA Set A

HY-RS16878

Dll4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dll4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dll4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dll4 Mouse Pre-designed siRNA Set A Dll4 Mouse Pre-designed siRNA Set A

HY-RS23320

Dll4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dll4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dll4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dll4 Rat Pre-designed siRNA Set A Dll4 Rat Pre-designed siRNA Set A

HY-P990252

*Anti-Mouse Delta-like protein 4/DLL4* Antibody (HMD4-2)**	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the *DLL4-Notch* signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma ^[4].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99377

Navicixizumab OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)	Notch	Cancer
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .

HY-P99261

Demcizumab OMP 21M18	Notch	Cancer
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models .

HY-P99852

Dilpacimab ABT165; PR1283233	VEGFR Notch	Cancer
Dilpacimab (ABT165) is a bispecific variable domain immunoglobulin. Dilpacimab binds to and inhibits *DLL4* and VEGF and acts as a tumor growth inhibitor. Dilpacimab can be used in research related to metastatic colorectal cancer and advanced solid tumors .

HY-P99925

Enoticumab REGN421	Notch	Metabolic Disease Cancer
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human *Dll4. DLL4* is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .

HY-P991033

Tovecimig CTX-009	VEGFR	Inflammation/Immunology
HY-P991033 is an *VEGFA/DLL4*-targeting G1-scFvlh_L-κ type bispecific antibody .

HY-P991423

MEDI0639 21H3RK	Notch	Cancer
MEDI0639 (21H3RK) is a human monoclonal antibody (mAb) targeting *DLL4. MEDI0639 inhibits Notch1* binding to Dll4. MEDI0639 reverses Notch1-mediated growth inhibition of human umbilical vein endothelial cells in vitro. MEDI0639 promotes human angiogenesis and reduces the number of vessels covered by smooth muscle actin-positive mural cells. MEDI0639 can be used in Small cell lung cancer and solid tumors research .

HY-P990252

*Anti-Mouse Delta-like protein 4/DLL4* Antibody (HMD4-2)**	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the *DLL4-Notch* signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma ^[4].

HY-P990402

*Anti-DLL4* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-DLL4 Antibody is a CHO-expressed human antibody targeting *DLL4. The Anti-DLL4* Antibody contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-DLL4 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122094

Steppogenin	Flavonoids Flavones Maclura tricuspidata Carriere Plants Moraceae Source Classification	HIF/HIF Prolyl-Hydroxylase
Steppogenin is a potent inhibitor of HIF-1α and *DLL4, with IC₅₀* values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and *4E-BP1* proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands *Dll4* and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections ^[4] .

Recombinant Proteins Recommended:

Delta-like 4 (DLL4)

Species:	Human (5) Rhesus Macaque (1) Mouse (2)
Tag:	His (4) Tag Free (1) Avi (2) Fc (3)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78116

	*Delta-like protein 4/DLL4* Protein, Human (Biotinylated, HEK293, His-Avi)** DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-10*His-Avi labeled tag.

HY-P72972

	*Delta-like protein 4/DLL4* Protein, Human (HEK293)** Delta-like protein 4; Delta4; DLL4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with tag free.

HY-P75292

	*Delta-like protein 4/DLL4* Protein, Mouse (HEK293, His)** Delta-like protein 4; Delta4; DLL4	Mouse	HEK293
	Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75293

	*Delta-like protein 4/DLL4* Protein, Mouse (HEK293, Fc)** Delta-like protein 4; Delta4; DLL4	Mouse	HEK293
	Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P75294

	*Delta-like protein 4/DLL4* Protein, Human (HEK293, Fc)** Delta-like protein 4; Delta4; DLL4	Human	HEK293
	The DLL4 protein, a homolog of the Drosophila delta gene family, encodes Notch ligands with a DSL domain, EGF repeats, and a transmembrane domain. DLL4 is widely expressed in tissues, including placenta (RPKM 11.5), fat (RPKM 11.2), and 22 others. Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76872

	*Delta-like protein 4/DLL4* Protein, Rhesus Macaque (HEK293, His)** Delta-like protein 4; Delta4; DLL4	Rhesus Macaque	HEK293
	delta-like protein 4 involves in the Notch signaling pathway as Notch ligand, and activates NOTCH1 and NOTCH4. delta-like protein 4 involves in angiogenesis. Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70111

	*Delta-like protein 4/DLL4* Protein, Human (HEK293, His)** rHuDelta-like protein 4/DLL4, His; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4	Human	HEK293
	Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P705013

	*Delta-like protein 4/DLL4* Protein, Human (Biotinylated, Fc-Avi)** delta-like 4 (Drosophila)	Human	HEK293

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Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
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Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ELISA (2)
Isotype:	IgG1 (1) IgG2b (1)
Conjugation:	Non-conjugated (2) Biotin (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87400

	DLL4 Antibody (YA7088)	IHC-P, ELISA	Human
	DLL4 Antibody (YA7088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DLL4.

HY-P87400A

	DLL4 Antibody (YA7088)(PBS only)	IHC-P, ELISA	Human
	DLL4 Antibody (YA7088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DLL4.

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Products	In-stock - + Add to Cart
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Host
Reactivity
Application
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Conjugation
Clonality
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Appearance
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Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS03810

DLL4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DLL4 Human Pre-designed siRNA Set A contains three designed siRNAs for DLL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16878

Dll4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dll4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dll4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23320

Dll4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dll4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dll4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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