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DON

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

3

Biochemical Assay Reagents

2

Inhibitory Antibodies

24

Natural
Products

1

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2

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108357
    6-Diazo-5-oxo-L-nor-Leucine
    10+ Cited Publications

    L-6-Diazo-5-oxonorleucine; DON

    Glutaminase Bacterial Influenza Virus Antibiotic Infection Cancer
    6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .
    6-Diazo-5-oxo-L-nor-Leucine
  • HY-122218
    JHU-083
    5+ Cited Publications

    Glutaminase Neurological Disease
    JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals .
    JHU-083
  • HY-N11678

    DON-3-β-D-glucoside; Deoxynivalenol 3-glucoside

    Drug Metabolite Metabolic Disease
    Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo .
    Deoxynivalenol-3-β-D-glucoside
  • HY-W099547

    Liposome Others
    Dihexadecyl hydrogen phosphateIt is an organic compound belonging to phospholipids. It's often used as an emulsifier, which means it helps mix two substances together that don't usually mix well, such as oil and water. Dihexadecyl hydrogen phosphateIt has several applications in the food industry, especially in the production of processed foods where it improves texture and stability. Additionally, it has applications in the pharmaceutical industry where it can be used ain the generation of micelles, liposomes, and other types of artificial membranes.
    Dihexadecyl hydrogen phosphate
  • HY-P991023

    6MW3211

    CD47 PD-1/PD-L1 Cancer
    Safimestomig (6MW3211) is an CD47/PD-L1-targeting bispecific antibody. Safimestomig blocks CD47-mediated 'don't eat me' signaling and selectively binds to CD47 on tumor cells. Safimestomig blocks PD-L1-mediated immune checkpoint signaling. Safimestomig can be used for the research of cancer .
    Safimestomig
  • HY-128775

    Drug Derivative Cancer
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST .
    JHU395
  • HY-D0854

    Acid Violet 19; Acid fuchsin sodium

    Environmental Pollutants Biochemical Assay Reagents Others
    Acid Red is a class of synthetic dyes commonly used in the textile, paper and ink industries. They are in the category of acid dyes, which means they are water soluble and have acidic properties. Acid Red dye produces bright, vibrant colors that don't fade easily, but are not as durable as some other dyes. They can be used to dye a wide variety of fibers including wool, silk and nylon, as well as paper and leather.
    Acid Red sodium
  • HY-N3706

    Fungal Infection
    Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L .
    Dehydro-α-lapachone
  • HY-N6685

    3-AcDON; 3-ADON

    Endogenous Metabolite Interleukin Related Infection Inflammation/Immunology
    3-Acetyldeoxynivalenol (3-AcDON; 3ADON), a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells .
    3-Acetyldeoxynivalenol
  • HY-179120

    Myosin Infection
    ZJS178 is a novel inhibitor of myosin I. ZJS178 is a fungicide that has inhibitory activity against Fusarium graminearum and can reduce DON toxin synthesis. ZJS178 can be used for research on plant diseases such as wheat scab .
    ZJS178
  • HY-108357R

    L-6-Diazo-5-oxonorleucine (Standard); DON (Standard)

    Reference Standards Glutaminase Bacterial Influenza Virus Antibiotic Infection Cancer
    6-Diazo-5-oxo-L-nor-Leucine (Standard) is the analytical standard of 6-Diazo-5-oxo-L-nor-Leucine. This product is intended for research and analytical applications. 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].
    6-Diazo-5-oxo-L-nor-Leucine (Standard)
  • HY-178717

    Fungal Infection
    WML-01 is a fungicide with EC50s of 0.079, 0.72 and 2.02 μg/mL against F. graminearum, F. fujikuroi and S. sclerotiorum. WML-01 disrupts the cell membrane of F. graminearum and induces deposition of lipid droplets. WML-01 inhibits Deoxynivalenol (DON) (HY-N6684) biosynthesis with no cross-resistance and strongly suppresses ribosomal subunit assembly, impairing protein synthesis. WML-01 effectively controls the fusarium head blight (FHB) epidemic .
    WML-01
  • HY-153151

    Drug Intermediate Cancer
    Fmoc-DON-Boc (Compound 8b) is an Fmoc-protected compound that can be used for the synthesis of proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357). DON is a glutamine antagonist .
    Fmoc-DON-Boc
  • HY-N3371

    (-)-Longikaurin E

    Others Others
    Longikaurin E is a diterpenoids compound isolated from the leaves of Rabdosia ternifolia (D. Don) .
    Longikaurin E
  • HY-N3067

    Others Others
    Picrasin B acetate is a Diterpenoids product that can be isolated from the herbs of Picrasma quassioides (D. Don) Benn .
    Picrasin B acetate
  • HY-N2726

    Others Others
    6'-O-p-Hydroxybenzoylcatalposide is a Iridoids product that can be isolated from the leaves of Catalpa ovata G. Don. .
    6'-O-p-Hydroxybenzoylcatalposide
  • HY-N1623

    Endogenous Metabolite Metabolic Disease
    1-Hydroxy-2,3,4,7-tetramethoxyxanthone is a metabolite of xanthone that can be found in Halenia elliptica D. Don .
    1-Hydroxy-2,3,4,7-tetramethoxyxanthone
  • HY-N11484

    Others Others
    5,6,7-Trihydroxyflavone-7-O-β-D-glucuronopyranoside is a natural product that can be isolated from the root of Scutellaria repens Buch.-Ham. ex D. Don .
    5,6,7-Trihydroxyflavone-7-O-β-D-glucuronopyranoside
  • HY-173051

    Parasite Infection
    Antiparasitic agent-24 (Compound 14a) is an antiparasitic agent, with EC50s of 0.005 μM (L. maj), 0.069 μM (L. don), 0.82 μM (T. brucei), 4.1 μM (T. cruzi) respectively .
    Antiparasitic agent-24
  • HY-N3552

    NF-κB Inflammation/Immunology
    Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .
    Catalposide
  • HY-168884

    mTOR Metabolic Disease
    AV457 is a potent and selective mTOR inhibitor with an IC50 value of 0.54 µM. AV457 inhibits cyst growth in polycystic kidney disease (PKD) organoids. AV457 decreases the protein expression of P-s6, P-p70s6 and don’t decreases the protein expression of P-AKT .
    AV457
  • HY-N6685S1

    3-AcDON-13C17; 3-ADON-13C17

    Isotope-Labeled Compounds Endogenous Metabolite Interleukin Related Infection Inflammation/Immunology
    3-Acetyldeoxynivalenol (3-AcDON; 3ADON)- 13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685). 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells .
    3-Acetyldeoxynivalenol-13C17
  • HY-N6685R

    3-AcDON (Standard); 3-ADON (Standard)

    Reference Standards Endogenous Metabolite Interleukin Related Infection Inflammation/Immunology
    3-Acetyldeoxynivalenol (3-AcDON; 3ADON) (Standard) is the analytical standard of 3-Acetyldeoxynivalenol (HY-N6685). This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells .
    3-Acetyldeoxynivalenol (Standard)
  • HY-155535

    17β-HSD Neurological Disease
    17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor,targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10),a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .
    17β-HSD10-IN-2
  • HY-N12820

    Others Cancer
    3-O-6-Deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-tenacigenin C can be isolated from Alocasia cucullata (Lour.) G. Don. 3-O-6-Deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-tenacigenin C has moderate tumor cells inhibitory activity against MGC-803 and HT-29 cells with IC50 values of 45.6 and 28.4 μg/mL, respectively .
    3-O-6-Deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-tenacigenin C
  • HY-NP0207

    DON-BSA

    Biochemical Assay Reagents Metabolic Disease
    Vomitoxin-BSA (DON-BSA) is an artificial antigen containing Deoxynivalenol (Vomitoxin) (HY-N6684) and BSA. Deoxynivalenol is one of the most important mycotoxins related to food chains. Vomitoxin-BSA can be used to generate anti-Deoxynivalenol monoclonal antibodies .
    Vomitoxin-BSA
  • HY-N11678S

    DON-3-β-D-glucoside-13C15; Deoxynivalenol 3-glucoside-13C15

    Isotope-Labeled Compounds Metabolic Disease
    Deoxynivalenol-3-β-D-glucoside- 13C15 (DON-3-β-D-glucoside- 13C15) is the 13C-labeled Deoxynivalenol-3-β-D-glucoside. Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo .
    Deoxynivalenol-3-β-D-glucoside-13C15
  • HY-N1271

    Others Others
    Scutellaric acid is a Triterpenoids product that can be isolated from the herb of Scutellaria barbata D. Don .
    Scutellaric acid
  • HY-N17320

    Drug Derivative Others
    Symplocosidin is a natural product that can be found in Symplocos sumuntia?Buch.-Ham. ex D. Don.
    Symplocosidin
  • HY-N1270

    Others Others
    Scutebata G is a Diterpenoids product that can be isolated from the herbs of Scutellaria barbata D.Don .
    Scutebata G
  • HY-N3402

    Abiesinol E; Listvenol

    Others Others
    Larixinol (Abiesinol E) is a Diterpenoids product that can be isolated from the herbs of Scutellaria barbata D. Don .
    Larixinol
  • HY-N9494

    Others Others
    6-O-Nicotiylbarbatin C is a Diterpenoids product that can be isolated from the herbs of Scutellaria barbata D. Don .
    6-O-Nicotiylbarbatin C
  • HY-N18735

    Others Inflammation/Immunology
    Quassia extract is obtained from the branches and leaves of Picrasma quassioides (D. Don) Benn. It has the effects of clearing away heat, removing dampness, and detoxification.
    Quassia extract
  • HY-N12838

    Others Others
    Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether is a phenolic derivative and can be isolated from Picrasma quassioides (D. Don) Benn .
    Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether
  • HY-N16720

    Reactive Oxygen Species (ROS) Inflammation/Immunology
    Picrasidine A is an active compound that can be extracted from the natural product Picrasma quassioides (D. Don) Benn. Picrasidine A has the potential to prevent UVB-induced reactive oxygen species (ROS) generation .
    Picrasidine A
  • HY-N15694

    Others Others
    1-Hydroxy-8-methoxy-3-methyl-6-O-β-D-glucopyranosyl-anthraquinone is an anthraquinone glucoside found in Polygonum macrophyllum D. Don .
    1-Hydroxy-8-methoxy-3-methyl-6-O-β-D-glucopyranosyl-anthraquinone
  • HY-N1853

    Drug Derivative Others
    3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide is a natural triterpene.
    3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide
  • HY-N9741

    Others Inflammation/Immunology
    (+)-Nyasol is a stilbene-type organic compound that can be naturally extracted from the dried roots of Asparagus filicinus Ham. ex D. Don (an Asparagus species) from Fenna, Tibet, China. This plant is traditionally used in the study of bronchitis, cough, and pneumonia, and can be used in research related to respiratory diseases .
    (+)-Nyasol
  • HY-N12768

    MDM-2/p53 Notch Calcium Channel Neurological Disease Inflammation/Immunology
    Rhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. Don
    (Ericaceae) (RM). Rhodojaponin VI binds rat N-Ethylmaleimide-sensitive fusion (NSF) with a Kd of 1.03 μM. Rhodojaponin VI blocks the MDM2-Notch1 signalling pathway by reducing MDM2 and Notch1 expression. Rhodojaponin VI indirectly reduces Cav2.2 current intensity by inhibiting NSF-mediated Cav2.2 trafficking. Rhodojaponin VI alleviates glomerulonephritis progression and podocyte injury in passive heymann nephritis rats. Rhodojaponin VI also has antinociceptive effects. Rhodojaponin VI can be used for the researches of heymann nephritis and pain .
    Rhodojaponin VI
  • HY-P992158

    CD47 Cancer
    VBI-009 is a CD47 and B7-H3 (CD276) bispecific antibody. VBI-009 blocks CD47-SIRPα 'don't eat me' signals and restricts activity to CD47 +/B7-H3 + cells. VBI-009 induces antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) in CD47 +/B7-H3 + tumor cells. VBI-009 inhibits tumor growth in CD47+/B7-H3+ lung cancer xenograft models. VBI-009 can be used for the research of lung cancer .
    VBI-009

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