GAS6

By Targets:	Akt (2) AMPK (1) Discoidin Domain Receptor (1) Hedgehog (1) Keap1-Nrf2 (1) NF-κB (1) p38 MAPK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) TAM Receptor (9) TGF-beta/Smad (1) TGF-β Receptor (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2995

Poricoic acid A 1 Publications Verification Poricoic acid A(F)	NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .

HY-119039

RU-301 1 Publications Verification	TAM Receptor	Inflammation/Immunology Cancer
RU-301 is a pan TAM inhibitor that blocks *Gas6*-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis .

HY-P99463

Batiraxcept 2 Publications Verification AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and *GAS6* inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

HY-124066

RU-302	TAM Receptor	Cancer
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC₅₀in cell assays, and suppresses lung cancer tumor growth .

HY-P99161

Tilvestamab BGB149	TAM Receptor	Cancer
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits *Gas6*-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

HY-RS16715

Gas6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gas6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gas6 Mouse Pre-designed siRNA Set A Gas6 Mouse Pre-designed siRNA Set A

HY-177332

SLC-391	TAM Receptor SARS-CoV Akt	Infection Cancer
SLC-391 is an orally active AXL kinase inhibitor with an IC₅₀ of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer .

HY-RS23150

Gas6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gas6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gas6 Rat Pre-designed siRNA Set A Gas6 Rat Pre-designed siRNA Set A

HY-RS05285

GAS6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GAS6 Human Pre-designed siRNA Set A contains three designed siRNAs for GAS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GAS6 Human Pre-designed siRNA Set A GAS6 Human Pre-designed siRNA Set A

HY-149092

Anticancer agent 109	TAM Receptor	Cancer
Anticancer agent 109 (compound 6-15) is an inhibitor of the *Gas6-Axl* axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models .

HY-P992231

*Anti-GAS6* Antibody (KM5321)**	TAM Receptor	Inflammation/Immunology
Anti-GAS6 Antibody (KM5321) is a humanized anti-GAS6 monoclonal antibody. Its isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-152075

AXL-IN-14	TAM Receptor	Cancer
AXL-IN-14 is a potent and orally active AXL inhibitor with an IC₅₀ value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity .

HY-179535

Axl-IN-21	TAM Receptor Discoidin Domain Receptor TGF-β Receptor Hedgehog	Cancer
Axl-IN-21 is an orally active and selective AXL inhibitor (K_d = 2.7 nM, IC₅₀ = 4.0 nM). Axl-IN-21 displays kinase selectivity and retains strong activity against cancer-related mul-kinases (Mer with K_d = 1.4 nM, DDR1 with IC₅₀ = 22.2 nM, HIPK4 with K_d = 11.0 nM and LOK with K_d =10 nM). Axl-IN-21 overcomes tumor microenvironment-driven resistance by blocking CAF-derived GAS6-induced AXL/STAT3/ABCG1 signaling, restoring chemosensitivity and inhibiting drug efflux in gastric cancer (GC). Axl-IN-21 suppresses TGF-β1-induced epithelial-mesenchymal transition (EMT), migration, and invasion in MDA-MB-231 cells. Axl-IN-21 exhibits no significant cytotoxicity in non-cancerous cells. Axl-IN-21 can be research for triple negative breast cancer and gastric cancer ^[1] ^[2].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99463

Batiraxcept 2 Publications Verification AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and *GAS6* inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

HY-P99161

Tilvestamab BGB149	TAM Receptor	Cancer
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits *Gas6*-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

HY-P992231

*Anti-GAS6* Antibody (KM5321)**	TAM Receptor	Inflammation/Immunology
Anti-GAS6 Antibody (KM5321) is a humanized anti-GAS6 monoclonal antibody. Its isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2995

Poricoic acid A 1 Publications Verification Poricoic acid A(F)	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS)
Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .

Species:	Human (6) Mouse (2) Cynomolgus (1)
Tag:	His (8) Fc (1)
Source:	HEK293 (9)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700723

	GAS6 Protein, Cynomolgus (HEK293, His) GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Cynomolgus	HEK293
	GAS6 Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. GAS6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704624

	GAS6 Protein, Human (400a.a, HEK293, His) GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (400a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293, with N-His labeled tag.

HY-P704625

	GAS6 Protein, Human (208a.a, HEK293, His) GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (208a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293, with N-His labeled tag.

HY-P700724

	GAS6 Protein, Human (630a.a, HEK293, His) 1 Publications Verification GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (630a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75174A

	GAS6 Protein, Mouse (HEK293, His) 1 Publications Verification AXLLG; AXSFAXL receptor tyrosine kinase ligand; GAS-6	Mouse	HEK293
	GAS6 Protein is a vitamin K-dependent protein involved in signaling pathways including GAS6/AXL. The GAS6 Protein contains an NH₂ terminal Gla domain as well as four EGF-like repeats and tandem gl bular domains. GAS6 Protein, Mouse (674a.a, HEK293, His) is the recombinant mouse-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75174

	GAS6 Protein, Mouse (HEK293, His, solution) AXLLG; AXSFAXL receptor tyrosine kinase ligand; GAS-6	Mouse	HEK293
	GAS6 Protein is a vitamin K-dependent protein involved in signaling pathways including GAS6/AXL. The GAS6 Protein contains an NH₂ terminal Gla domain as well as four EGF-like repeats and tandem gl bular domains. GAS6 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70780A

	GAS6 Protein, Human (HEK293, His) AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes.GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses.GAS6 Protein, Human (HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70470

	GAS6 Protein, Human (HEK293, Fc) AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	GAS6 Protein is a secreted protein located outside the cell membrane. GAS6 Protein is a ligand for tyrosine protein kinase receptors AXL, TYRO3, and MER, and its signal transduction is related to cell growth and survival, cell adhesion, and cell migration. GAS6 is associated with tumor cell growth, metastasis, invasion, epithelial mesenchymal transition, angiogenesis, drug resistance, immune regulation, and stem cell maintenance after binding to AXL. GAS6 Protein, Human (HEK293, Fc) is a recombinant GAS6 protein with an Fc tag, expressed by HEK293.

HY-P70780

	GAS6 Protein, Human (HEK293, His, solution) 3 Publications Verification AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; GAS6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6	Human	HEK293
	The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Mouse (HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P85881

	Gas6 Antibody (YA5573) GAS6; AXLLG; Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand	WB, ICC/IF, ELISA	Human
	Gas6 Antibody (YA5573) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Gas6.

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Cat. No.	Product Name		Classification

HY-RS16715

Gas6 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gas6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23150

Gas6 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gas6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05285

GAS6 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GAS6 Human Pre-designed siRNA Set A contains three designed siRNAs for GAS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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