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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
GPR17
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "GPR17" in MCE Product Catalog:
4
4 Cited Publications
Referencia número: HY-19638A
No. CAS: 163706-36-3
Synonyms: AR-C69931MX tetrasodium
Target:
Áreas de investigación:
Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist .
Target:
Áreas de investigación:
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes .
Referencia número: HY-170589
No. CAS: 1574405-61-0
Target:
Áreas de investigación:
GPR17 antagonist 1 (compound 978) is a GPR17 antagonist. GPR17 antagonist 1 can be used in the study of diabetes and obesity .
Referencia número: HY-19638
No. CAS: 163706-06-7
Synonyms: AR-C69931MX
Target:
Áreas de investigación:
Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist .
Referencia número: HY-164311
No. CAS: 3039853-91-0
Target:
Áreas de investigación:
GPR17 modulator-1 (Compound 2-046) is a modulator for G protein-coupled receptor 17 GPR17, with an IC50<10 nM for hGPR17 in CHO. GPR17 modulator-1 exhibits moderate pharmacokinetic characteristics in mice. GPR17 modulator-1 ix blood-brain barrier (BBB) permeable .
Target:
Áreas de investigación:
ASN04885796 (compound IV) is an GPR17 activator with an EC50 of 2.27 nM for GPR17 induced GTPγS binding. ASN04885796 has neuroprotective property and can be used for research of neurological diseases .
Target:
Áreas de investigación:
ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases. ASN06917370 has an EC50 of 268 pM in [35S]GTPyS experiments .
Referencia número: HY-RS05679
Target:
Áreas de investigación:
GPR17 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Áreas de investigación:
ASN02563583, a compound that regulates the activity of the GPR17 receptor, has a IC50 value of 0.64 nM in [35S]GTPγS binding assay. ASN02563583 can be used in the study of neurological diseases .
Referencia número: HY-181738
Target:
Áreas de investigación:
GPR17 agonist 2 (compound 10) is a human GPR17 agonist and selective P2Y receptor non-activator.GPR17 agonist 2 modulates intracellular cAMP levels through functional activation of its target receptor.GPR17 agonist 2 can be used for the research of multiple sclerosis, cerebral ischemia, traumatic brain injury, spinal cord injury .
Referencia número: HY-RS17462
Target:
Áreas de investigación:
Gpr17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS23920
Target:
Áreas de investigación:
Gpr17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-125313
No. CAS: 139896-80-3
Target:
Áreas de investigación:
PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia .
Referencia número: HY-19638AR
No. CAS: 163706-36-3
Synonyms: AR-C69931MX tetrasodium (Standard)
Target:
Áreas de investigación:
Cangrelor (tetrasodium) (Standard) is the analytical standard of Cangrelor (tetrasodium). This product is intended for research and analytical applications. Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist .
Referencia número: HY-159920
Target:
Áreas de investigación:
PSB-22269 is a competitive GPR17 antagonist. PSB-22269 can be used in research on multiple sclerosis .
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders .
Referencia número: HY-P705954
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPR17; UDP/CysLT Receptor; G Protein-Coupled Receptor 17; P2Y-Like Receptor; Uracil Nucleotide/Cysteinyl Leukotriene Receptor; R12; G-Protein Coupled Receptor 17
Species:
Human
Source:
E. coli Cell-free
Referencia número: HY-182724
No. CAS: 2244978-64-9
Target:
Áreas de investigación:
PSB-18422 is a GPR17 agonist, with an EC50 of 0.0279 μM for humans, 0.47 μM for rats, 0.753 μM for mice, and a human Ki of 1.46 μM. PSB-18422 triggers intracellular calcium mobilization via cross-species activation of GPR17. PSB-18422 can be used in the research of allergic bronchial inflammation .
Referencia número: HY-179606
No. CAS: 2877694-62-5
Áreas de investigación:
RWT9996 is a GPR17 antagonist. RWT9996 inhibits GPR17-mediated signal transduction processes, including G protein activation and β-arrestin-2 recruitment. RWT9996 inhibits MDL-29951 (HY-16312)-mediated phosphorylation of ERK1/2, phosphorylation of CREB, and accumulation of inositol phosphate (IP1) in oligodendrocyte precursor cells in vitro. RWT9996 can be used in studies related to demyelinating diseases .
Referencia número: HY-107752A
No. CAS: 851191-73-6
Target:
Áreas de investigación:
2-(Phenylethynyl)-ATP ammonium is a selective and potent GPR17 agonist with an EC50 of 35 pM. 2-(Phenylethynyl)-ATP ammonium also shows weak activation of P2Y Receptor. 2-(Phenylethynyl)-ATP ammonium can be used for the research of neurological disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
