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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
Gli1
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "Gli1" in MCE Product Catalog:
68
9
2
2 Cited Publications
Synonyms: LY2940680
Taladegib is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers [1] .
2
2 Cited Publications
Referencia número: HY-N2112
No. CAS: 79498-31-0
2
2 Cited Publications
Referencia número: HY-18366A
No. CAS: 1782573-67-4
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity [1].
2
2 Cited Publications
Referencia número: HY-13242A
No. CAS: 1258861-21-0
Synonyms: LY2940680 hydrochloride
Taladegib (LY2940680) hydrochloride is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib hydrochloride binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib hydrochloride can be used in studies of Hedgehog pathway-related cancers [1] .
1
1 Cited Publications
Referencia número: HY-P4860
No. CAS: 1802086-30-1
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-P83731
Synonyms: Gli 1; Gli1; Gli-1; Gli; Gli Kruppel family member 1; Glioma associated oncogene; Glioma associated oncogene homolog 1 (zinc finger protein); Oncogene Gli; Zfp 5; Zfp5; Zinc finger protein Gli 1; Zinc finger protein Gli1; Gli1_HUMAN.
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells [1] .
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner [1] .
Referencia número: HY-RS05472
Target:
Áreas de investigación:
GLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-18366
No. CAS: 1043797-53-0
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity [1].
Referencia número: HY-RS05473
Target:
Áreas de investigación:
Gli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS05474
Target:
Áreas de investigación:
Gli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-143400
No. CAS: 2882053-89-4
HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 [1].
Referencia número: HY-172449
GLI1-IN-3 (Compound 11a), a triterpenoid analogue, can inhibit Hedgehog signaling in GLI1 overexpression cancer cells. GLI1-IN-3 inhibits the proliferation in NSCLC and prostate cancer cell lines exhibiting hyper-activated Hh signaling. GLI1-IN-3 can also decrease the expression of endogenous GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells [1].
Referencia número: HY-W111144
No. CAS: 106461-41-0
T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression [1].
Referencia número: HY-161459
No. CAS: 2923907-92-8
GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway [1].
Áreas de investigación:
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
