180 Results for "

Glycogen

" in MedChemExpress (MCE) Product Catalog:
Products (180)

180 Results for "Glycogen" in MCE Product Catalog:

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22
22 Publications Verification
Cat. No.: HY-16294
CAS No.: 603288-22-8
Target:  

GSK-3

Research Areas:  

Cancer

LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
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18
18 Cited Publications
Cat. No.: HY-N0143
CAS No.: 60-81-1
Synonyms: Floridzin
Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities .
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18
18 Cited Publications
Cat. No.: HY-N0143A
CAS No.: 7061-54-3
Synonyms: Floridzin dihydrate
Phlorizin (Floridzin) dihydrate is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin dihydrate promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin dihydrate reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin dihydrate induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin dihydrate also exhibits antibacterial, anti-inflammatory and neuroprotective activities .
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13
13 Cited Publications
Cat. No.: HY-15424
CAS No.: 24386-93-4
Purity:  99.64%
Synonyms: NSC 113939; 5-ITu
Target:  

Adenosine Kinase

Research Areas:  

Cancer

5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .
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9
9 Cited Publications
Cat. No.: HY-13525
CAS No.: 186392-40-5
Purity:  99.80%
Research Areas:  

Metabolic Disease Cancer

CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study .
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6
6 Cited Publications
Cat. No.: HY-113914
CAS No.: 1034895-42-5
Purity:  99.13%
Synonyms: Elraglusib
Target:  

GSK-3 Apoptosis Autophagy

Research Areas:  

Cancer

9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents .
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4
4 Cited Publications
Cat. No.: HY-157646
CAS No.: 2839908-40-4
Purity:  98.98%
Synonyms: GYS1-IN-2
Target:  

Glycosyltransferase

Research Areas:  

Metabolic Disease

MZ-101 (GYS1-IN-2) is an orally active, potent and selective small-molecule glycogen synthase 1 (GYS1) inhibitor with with an IC50 value of 0.041 µM. MZ-101 reduces glycogen concentrations in cells and in mice. MZ-101 can used to study GYS1 -mediated Pompe disease and other glycogen storage diseases .
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4
4 Cited Publications
Cat. No.: HY-112537
CAS No.: 56-73-5
Purity:  99.90%
D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .
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4
4 Cited Publications
Cat. No.: HY-107207
CAS No.: 32602-81-6
Purity:  99.68%
Synonyms: Kaempferol 3-O-neohesperidoside
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .
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3
3 Cited Publications
Cat. No.: HY-59090
CAS No.: 676596-65-9
Synonyms: 1-Akp
Target:  

GSK-3

1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM .
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3
3 Cited Publications
Cat. No.: HY-112537B
CAS No.: 54010-71-8
Purity:  ≥98.0%
D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .
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3
3 Cited Publications
Cat. No.: HY-N7676
CAS No.: 535-96-6
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .
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2
2 Cited Publications
Cat. No.: HY-113511
CAS No.: 9005-79-2
Purity:  99.3%
Glycogen, Mussel is a glycolytic intermediates and high-energy phosphates that can serve as a form of energy storage in humans, animals, fungi, and bacteria .
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2
2 Cited Publications
Cat. No.: HY-19396
CAS No.: 186392-65-4
Synonyms: CP 368296; GPi 296
Target:  

Phosphorylase

Research Areas:  

Cardiovascular Disease

Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
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2
2 Cited Publications
Cat. No.: HY-P0315
CAS No.: 171783-05-4
Target:  

Akt

Research Areas:  

Others

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.
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2
2 Cited Publications
Cat. No.: HY-131062
CAS No.: 2415003-97-1
Purity:  98.69%
Target:  

Glycosyltransferase

Research Areas:  

Metabolic Disease

yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .
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2
2 Cited Publications
Cat. No.: HY-P80820
Synonyms: GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Cat. No.: HY-Y1110I
CAS No.: 7786-30-3
Synonyms: Magnogene, for insect cell culture, 97%
Magnesium chloride, for insect cell culture, 97% is an orally active inorganic mineral salt. Magnesium chloride combined with Potassium chloride (HY-Y0537E) increases the fat body glycogen, protein, total lipids and haemolymph protein and trehalose in the silkworm, Bombyx mori L .
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1
1 Cited Publications
Cat. No.: HY-K0604

MCE Periodic Acid-Schiff (PAS) Staining Kit is developed based on the classical Periodic Acid–Schiff (PAS) reaction principle and is suitable for the detection of glycogen and polysaccharide-containing substances in paraffin-embedded or frozen tissue sections.

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1
1 Cited Publications
Cat. No.: HY-141480
CAS No.: 1448990-73-5
Purity:  99.22%
Target:  

GSK-3 Apoptosis

Research Areas:  

Cancer

GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia .
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