2. Search Result
Search Result
Isoforms Recommended: LATS2
Results for "

LATS2

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Recombinant Proteins

1

Antibodies

1

Click Chemistry

6

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-138489
    TRULI
    Maximum Cited Publications
    27 Publications Verification

    LATS-IN-1

    		 Ser/Thr Kinase Large Tumor Suppressor (LATS) Others
    TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .
    TRULI
  • HY-147082
    GA-017
    5+ Cited Publications

    		 Large Tumor Suppressor (LATS) YAP Cancer
    GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .
    GA-017
  • HY-147165
    VT02956
    1 Publications Verification

    		 Ser/Thr Kinase Large Tumor Suppressor (LATS) Cancer
    VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT02956
  • HY-W087830
    L-p-Boronophenylalanine

    L-BPA

    		 Biochemical Assay Reagents Cancer
    L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma [2].
    L-p-Boronophenylalanine
  • HY-164254
    Cardiomyocyte proliferation promoting agent-1

    (E/Z)-GA-002

    		 Large Tumor Suppressor (LATS) YAP Cardiovascular Disease Inflammation/Immunology Cancer
    Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP [2].
    Cardiomyocyte proliferation promoting agent-1
  • HY-175649
    LATS1/2-IN-1

    		Large Tumor Suppressor (LATS) YAP Cancer
    LATS1/2-IN-1 is a potent and selective LATS1 and LATS2 inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and LATS2 with IC50 values of 4.4 nM and 5.5 nM as determined via r 33P functional assay. LATS1/2-IN-1 displays cellular IC50 values of 136 nM for LATS1 and 36.0 nM for LATS2 as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing .
    LATS1/2-IN-1
  • HY-RS07539
    LATS2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LATS2 Human Pre-designed siRNA Set A
    LATS2 Human Pre-designed siRNA Set A
  • HY-RS18181
    Lats2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lats2 Mouse Pre-designed siRNA Set A
    Lats2 Mouse Pre-designed siRNA Set A
  • HY-RS24655
    Lats2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lats2 Rat Pre-designed siRNA Set A
    Lats2 Rat Pre-designed siRNA Set A
  • HY-130504
    Propargyl-PEG1-acid
    1 Publications Verification

    		 PROTAC Linkers Cancer
    Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-acid
  • HY-147165A
    VT02956 hydrochloride

    		YAP Large Tumor Suppressor (LATS) Cancer
    VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT02956 hydrochloride
  • HY-164401
    QBS10072S

    		EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker Neurological Disease Cancer
    QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma [2].
    QBS10072S
  • HY-RS07537
    LAT2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LAT2 Human Pre-designed siRNA Set A
    LAT2 Human Pre-designed siRNA Set A
  • HY-RS21361
    Lat2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lat2 Mouse Pre-designed siRNA Set A
    Lat2 Mouse Pre-designed siRNA Set A
  • HY-RS27880
    Lat2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Lat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Lat2 Rat Pre-designed siRNA Set A
    Lat2 Rat Pre-designed siRNA Set A
  • HY-164401A
    QBS10072S dihydrochloride

    		EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker Neurological Disease Cancer
    QBS10072S dihydrochloride is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S dihydrochloride exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S dihydrochloride can be used for the research of glioblastoma and aggressive T-cell lymphoma [2].
    QBS10072S dihydrochloride

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: