2 Results for "

M-07e cells

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "M-07e cells" in MCE Product Catalog:

Cat. No.: HY-182043
CAS No.: 2999638-62-7
Target:  

c-Kit PDGFR

Research Areas:  

Cancer

BLU-654 is an orally active antineoplastic agent and KIT inhibitor. BLU-654 is a highly selective inhibitor targeting wild-type KIT, PDGFRβ, and KIT V654A over most other kinases in the kinome. BLU-654 exerts sustained antineoplastic activity in KIT V654A cell-derived xenograft mouse models. BLU-654 can be used in research related to Imatinib (HY-15463)-resistant gastrointestinal stromal tumors .
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Cat. No.: HY-P992509
Synonyms: NCT02642016; KTN0158

Target:  

c-Kit

Research Areas:  

Cancer

CDX-0158 (NCT02642016; KTN0158) is a humanized anti-c-Kit/CD117 IgG1κ monoclonal antibody. CDX-0158 effectively blocks the SCF-KIT signaling pathway and inhibits mast cell activation, but due to the retention of wild-type IgG1 Fc, it can induce mast cell degranulation through FcyR cross-linking, resulting in obvious infusion reactions. CDX-0158 can be used in research related to advanced refractory gastrointestinal stromal tumors .
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