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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
83 Results for "
Methotrexate
" in MedChemExpress (MCE) Product Catalog:
Products (83)
83 Results for "Methotrexate" in MCE Product Catalog:
80
80 Publications Verification
Synonyms: Amethopterin; CL14377; WR19039
Forschungsgebiete:
Infection Neurological Disease Inflammation/Immunology Cancer
Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
80
80 Publications Verification
Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium
Forschungsgebiete:
Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
80
80 Publications Verification
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
17
17 Cited Publications
Synonyms: Leucovorin calcium; Calcium folinate
Target:
17
Category:
Human Gut Microbiota Metabolites Natural Products Plants Moraceae Endogenous metabolite Disease Research Fields Cancer Morus alba Linn.
Target:
17
17 Cited Publications
Synonyms: Leucovorin calcium salt pentahydrate
Target:
7
Category:
Flavonols Flavonoids Leguminosae Plants Vigna unguiculata Disease Research Fields Inflammation/Immunology
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3
3 Cited Publications
Art. -Nr.: HY-P1197
CAS. Nr.: 478507-53-8
Target:
Forschungsgebiete:
3
3 Cited Publications
Art. -Nr.: HY-P1197A
Target:
Forschungsgebiete:
2
2 Cited Publications
(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
Forschungsgebiete:
Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation .
1
Target:
Forschungsgebiete:
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
Art. -Nr.: HY-14519S
CAS. Nr.: 432545-63-6
Art. -Nr.: HY-127009
CAS. Nr.: 68538-85-2
Synonyms: Levofolinic acid; Levofolene
Target:
Target:
Forschungsgebiete:
7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
Art. -Nr.: HY-W086988
CAS. Nr.: 136-85-6
Synonyms: 5-Methylbenzotriazole
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Forschungsgebiete:
5-Methyl-1H-benzotriazole (5-Methylbenzotriazole) is a benzotriazole derivative, and serves as a key building block for ultraviolet absorbers and light stabilizers. 5-Methyl-1H-benzotriazole reduces the photosensitizing ability of nitrate and dissolved organic matter (DOM), enhances the persistence of microorganic pollutants, inhibits the photodegradation of DOM and drug residues, and quenches the triplet excited states of DOM and methotrexate substructures. 5-Methyl-1H-benzotriazole acts as a corrosion inhibitor for copper and copper alloys, and is present in formulations of anti-icing fluids, dishwasher detergents, aircraft deicing fluids and automotive antifreezes .
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Forschungsgebiete:
Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .
Synonyms: Amethopterin (Standard); CL14377 (Standard); WR19039 (Standard)
Forschungsgebiete:
Methotrexate (Standard) is the analytical standard of Methotrexate. This product is intended for research and analytical applications. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .
Art. -Nr.: HY-W047788
CAS. Nr.: 10270-94-7
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Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
