10051 Results for "

Modified Skraup reaction

" in MedChemExpress (MCE) Product Catalog:
Products (10051)

10051 Results for "Modified Skraup reaction" in MCE Product Catalog:

167
167 Publications Verification
Cat. No.: HY-D1301
CAS No.: 217075-36-0
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
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78
78 Cited Publications
Cat. No.: HY-K0501A

MCE SYBR Green qPCR Master Mix (Universal) is compatible with all qPCR instruments. 2× ready-to-use formulations which consist of antibody-mediated hot start polymerase, MgCl2, dNTPs and a proprietary reaction buffer, produce optimal results in qPCR experiments. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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74
74 Cited Publications
Cat. No.: HY-D0924
CAS No.: 210892-23-2
Synonyms: Sulfo-Cyanine5.5
Cy5.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
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56
56 Cited Publications
Cat. No.: HY-12588
CAS No.: 1009816-48-1
Purity:  99.99%
Target:  

OGA Autophagy

Research Areas:  

Cancer

Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
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53
53 Cited Publications
Cat. No.: HY-B0445A
CAS No.: 20111-18-6
Synonyms: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .
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52
52 Cited Publications
Cat. No.: HY-W250163
CAS No.: 64417-72-7
Synonyms: β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .
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48
48 Cited Publications
Cat. No.: HY-D0821
CAS No.: 146368-11-8
Synonyms: Sulfo-Cyanine5
Target:  

Fluorescent Dye

Research Areas:  

Cancer

CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
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46
46 Cited Publications
Cat. No.: HY-108882C
CAS No.: 9003-98-9
Target:  

DNA/RNA Synthesis

Research Areas:  

Inflammation/Immunology

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .
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45
45 Cited Publications
Cat. No.: HY-D0819
CAS No.: 146368-14-1
Synonyms: Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester
Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.
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40
40 Cited Publications
Cat. No.: HY-118411
CAS No.: 61135-33-9
Purity:  99.78%
Synonyms: EdU
Target:  

PROTAC Linkers

Research Areas:  

Cancer

5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation . 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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35
35 Cited Publications
Cat. No.: HY-F0004
CAS No.: 1094-61-7
Synonyms: β-Nicotinamide mononucleotide; β-NM; NMN
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
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32
32 Cited Publications
Cat. No.: HY-K2005

High Sensitivity ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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30
30 Cited Publications
Cat. No.: HY-16637D
CAS No.: 29704-76-5
Synonyms: Vitamin B9 disodium; Vitamin M disodium
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 5 g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .
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26
26 Cited Publications
Cat. No.: HY-B0220
CAS No.: 114-07-8
Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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26
26 Cited Publications
Cat. No.: HY-B0220A
CAS No.: 3847-29-8
Research Areas:  

Infection Cancer

Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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26
26 Cited Publications
Cat. No.: HY-B0220D
CAS No.: 7704-67-8
Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
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24
24 Cited Publications
Cat. No.: HY-D0086
CAS No.: 67483-13-0
Synonyms: MDL101114ZA
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .
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23
23 Cited Publications
Cat. No.: HY-W011500
CAS No.: 51805-45-9
Synonyms: Tris(2-​carboxyethyl)​phosphine hydrochloride
Target:  

Drug Derivative

Research Areas:  

Others

TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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23
23 Cited Publications
Cat. No.: HY-W099571
CAS No.: 4485-12-5
Synonyms: Stearic acid lithium; Lithium octadecanoate
Lithium stearate (Stearic acid (lithium)) is a compound that forms vesicles in reaction with silver nitrate, thereby changing the reaction kinetics of the nucleation and self-assembly process of silver stearate. It has the activity that even in the presence of excess silver nitrate, only about 80% can be converted into silver stearate and the residual lithium stearate will inhibit the growth process of silver stearate crystals, thereby producing silver stearate crystals that are much smaller than those obtained from sodium stearate, providing an opportunity to further control the self-assembly and crystal growth of silver stearate.
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23
23 Cited Publications
Cat. No.: HY-113324
CAS No.: 53-57-6
Purity:  99.49%
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .
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