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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
NF-κB-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "NF-κB-IN-2" in MCE Product Catalog:
Cat. No.: HY-142958
CAS No.: 1821386-63-3
Target:
Research Areas:
NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.
63
63 Publications Verification
Cat. No.: HY-N0197
CAS No.: 21967-41-9
Synonyms: BaicaleIN 7-O-β-D-glucuronide
7
3
3 Cited Publications
Cat. No.: HY-N1404
CAS No.: 20977-05-3
Category:
Triterpenes Hippocastanaceae Terpenoids Aesculus hippocastanum Plants Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Cat. No.: HY-N1993
CAS No.: 82517-12-2
Target:
3
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:
Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.
Target:
2
1
1
Synonyms: OlomoucIN
Research Areas:
Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research .
Category:
Flavonoids Chalcones Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields
Target:
Category:
Coumarins Phenylpropanoids Plants Umbelliferae Pluchea indica (L.) Less. Disease Research Fields Inflammation/Immunology
Target:
Synonyms: MesalamINe-d3; 5-ASA-d3; MesalazINe-d3
Cat. No.: HY-W014223
CAS No.: 131-56-6
Synonyms: Ultraviolet absorber UV-0
Target:
Environmental Pollutants Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) MyD88 IRAK
Research Areas:
2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber .
Cat. No.: HY-N12717
CAS No.: 79786-01-9
Cat. No.: HY-N0197R
CAS No.: 21967-41-9
Synonyms: BaicaleIN 7-O-β-D-glucuronide (Standard)
Synonyms: TRB-N0224
Research Areas:
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis .
Synonyms: MesalamINe-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; MesalazINe-13C6 hydrochloride
Cat. No.: HY-N0894R
CAS No.: 36062-07-4
Synonyms: HexahydrobisdemethoxycurcumIN (Standard)
Category:
Target:
Cat. No.: HY-174829
CAS No.: 13198-99-7
Target:
Protease Activated Receptor (PAR) NF-κB Reactive Oxygen Species (ROS) Calcium Channel Akt ERK p38 MAPK PKC
Research Areas:
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, Ca 2+/protein kinase C, Akt, ERK and p38. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice.
7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time [1][2].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
