Search Result

Results for "

NPFF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRFR (2) GnRH Receptor (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) Neuropeptide FF Receptor (10) Neuropeptide Y Receptor (10) Opioid Receptor (1) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (14)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1248

Neuropeptide FF NPFF	Neuropeptide FF Receptor	Cardiovascular Disease Neurological Disease
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a *NPFF1* and NPFF2 receptors agonist with K_i values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain .

HY-107726

BIBP3226 TFA 1 Publications Verification	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF *(NPFF) receptor* antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect .

HY-161405

NPFF1-R antagonist 1	Neuropeptide FF Receptor Opioid Receptor	Neurological Disease
NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent *neuropeptide FF (NPFF) receptor* antagonist. NPFF1-R antagonist 1 is 15-fold selective for the *NPFF1-R* subtype, with K_i values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively .

HY-P10377

GUB03385	Neuropeptide FF Receptor	Metabolic Disease
GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC₅₀: 0.4 nM) and *NPFF2R* (partial agonist, EC₅₀: 20 nM). GUB03385 has anti-obesity effect .

HY-P1428

RFRP-1(human) 1 Publications Verification	Neuropeptide Y Receptor	Endocrinology
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for *NPFF2* and *NPFF1*, respectively .

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human); Neuropeptide NPVF (human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca ²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM .

HY-P1245

Neuropeptide SF (human) Neuropeptide NPFF (human)	CRFR	Others
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .

HY-P10380

palm11-PrRP31	Neuropeptide FF Receptor	Neurological Disease Metabolic Disease
palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39 pM) and *NPFF-R2* effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .

HY-107726A

BIBP3226	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF *(NPFF) receptor* antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect .

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀ of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors *NPFF1* (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and *NPFF2* (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .

HY-154829A

AC-099 hydrochloride	Neuropeptide FF Receptor	Inflammation/Immunology
AC-099 hydrochloride (compound 3) is a selective *NPFF2R* full agonist (EC₅₀=1189 nM) and *NPFF1R* partial agonist (EC₅₀=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats .

HY-161382

NPFF2-R ligand 1	Neuropeptide FF Receptor	Neurological Disease
NPFF2-R ligand 1 (Compound 16a) is a *NPFF2-R* ligand, with K_is of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system .

HY-P10380A

palm11-PrRP31 TFA	Neuropeptide FF Receptor	Neurological Disease Metabolic Disease
palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC₅₀=39 pM) and *NPFF-R2* effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .

HY-RS16912

Npff Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Npff Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npff gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Npff Mouse Pre-designed siRNA Set A Npff Mouse Pre-designed siRNA Set A

HY-RS09480

NPFF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPFF Human Pre-designed siRNA Set A contains three designed siRNAs for NPFF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPFF Human Pre-designed siRNA Set A NPFF Human Pre-designed siRNA Set A

HY-154829

AC-099	Neuropeptide FF Receptor	Inflammation/Immunology
AC-099 (compound 3) is a selective *NPFF2R* full agonist (EC₅₀=1189 nM) and *NPFF1R* partial agonist (EC₅₀=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats .

HY-P1428A

RFRP-1(human) TFA	Neuropeptide Y Receptor	Cardiovascular Disease
RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC₅₀ values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.

HY-P1249

Neuropeptide SF(mouse,rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1249A

Neuropeptide SF(mouse,rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1245A

Neuropeptide SF (human) acetate Neuropeptide NPFF (human) acetate	CRFR	Others
Neuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .

HY-P10379

palm-PrRP31	Neuropeptide FF Receptor	Others Neurological Disease
palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC₅₀=72 pM) and *NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10* and *NPFF-R2*, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .

HY-P1250A

RFRP-3(human) TFA Neuropeptide VF(124-131)(human) TFA; Neuropeptide NPVF (human) TFA	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca ²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM .

HY-RS23354

Npff Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Npff Rat Pre-designed siRNA Set A contains three designed siRNAs for Npff gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Npff Rat Pre-designed siRNA Set A Npff Rat Pre-designed siRNA Set A

HY-107726R

BIBP3226 TFA (Standard)	Reference Standards Neuropeptide Y Receptor	Neurological Disease
BIBP3226 TFA (Standard) is the analytical standard of BIBP3226 (TFA) (HY-107726). This product is intended for research and analytical applications. BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect .

HY-P11810

GUB08248	GnRH Receptor Neuropeptide FF Receptor	Metabolic Disease
GUB08248 is a full GPR10 agonist and a partial *NPFF2R* agonist, with EC₅₀ values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research .

Cat. No.	Product Name	Target	Research Area