Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
321 Results for "
PPP
" in MedChemExpress (MCE) Product Catalog:
Products (321)
321 Results for "PPP" in MCE Product Catalog:
31
31 Publications Verification
Synonyms: AXL1717; Picropodophyllotoxin; PPP
11
11 Cited Publications
Cat. No.: HY-P0019
CAS No.: 66216-78-2
Target:
Research Areas:
11
11 Cited Publications
Cat. No.: HY-P0019A
CAS No.: 2070009-61-7
Target:
Research Areas:
4
4 Cited Publications
Synonyms: Sephin1; IFB-088
Target:
Research Areas:
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
3
3 Cited Publications
Cat. No.: HY-W009371
CAS No.: 18265-46-8
3
3 Cited Publications
Cat. No.: HY-W009371C
CAS No.: 207671-46-3
Target:
3
3 Cited Publications
Target:
Research Areas:
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease .
3
3 Cited Publications
Target:
Research Areas:
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease .
1
1 Cited Publications
Target:
Research Areas:
NKL 22 is a potent and selective inhibitor of histone deacetylases (HDAC), with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 can reverse abnormal expression of HD‑related genes and restore the levels of key genes including Ppp1r1b in Huntington's disease transgenic mice. NKL 22 can be used for the researches of Huntington's disease and cancer .
1
1 Cited Publications
Cat. No.: HY-126876
CAS No.: 1178583-19-1
Research Areas:
GL-V9 inhibits proliferation of HepG2 cell (IC50 is 35.2 μM) through induction of apoptosis and cell cycle arrest at G2/M phase. GL-V9 regulates mitochondrial membrane potential and increases the production of intracellular reactive oxygen species. GL-V9 inhibits the pentose phosphate pathway (PPP), enhances fatty acid oxidation (FAO) through activation of AMPK, and thus inhibits the metastasis of cancer cells. GL-V9 exhibits antitumor efficacy in mouse model .
1
1 Cited Publications
Cat. No.: HY-P76759
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CALNA; CNA
Species:
Source:
1
1 Cited Publications
Cat. No.: HY-P80460
Synonyms: FAK, FAK1, PTK2, Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FRNK, PPP1R71
1
1 Cited Publications
Cat. No.: HY-P72224
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; Histone deacetylase 6 HD6; ; Histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90
Cat. No.: HY-RS10992
Target:
Research Areas:
PPP1R1A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11007
Target:
Research Areas:
PPP2CA Human Pre-designed siRNA Set A contains three designed siRNAs for PPP2CA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21174
Target:
Research Areas:
Ppp2ca Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp2ca gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10986
Target:
Research Areas:
PPP1R15A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R15A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11009
Target:
Research Areas:
PPP2R1A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP2R1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10973
Target:
Research Areas:
PPP1CA Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1CA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10974
Target:
Research Areas:
PPP1CB Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1CB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
